Biomaterial hypersensitivity: is it real? Supportive evidence and approach considerations for metal allergic patients following total knee arthroplasty.

Abstract:

:The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failure may ultimately be related to metal hypersensitivity. The examination of hypersensitivity reactions in current-generation metal-on-metal knee implants is comparatively limited. The purpose of this study is to summarize all available literature regarding biomaterial hypersensitivity after total knee arthroplasty, elucidate overall trends about this topic in the current literature, and provide a foundation for clinical approach considerations when biomaterial hypersensitivity is suspected.

journal_name

Biomed Res Int

authors

Mitchelson AJ,Wilson CJ,Mihalko WM,Grupp TM,Manning BT,Dennis DA,Goodman SB,Tzeng TH,Vasdev S,Saleh KJ

doi

10.1155/2015/137287

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

137287

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

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