Abstract:
:The prediction of RNA-binding proteins is one of the most challenging problems in computation biology. Although some studies have investigated this problem, the accuracy of prediction is still not sufficient. In this study, a highly accurate method was developed to predict RNA-binding proteins from amino acid sequences using random forests with the minimum redundancy maximum relevance (mRMR) method, followed by incremental feature selection (IFS). We incorporated features of conjoint triad features and three novel features: binding propensity (BP), nonbinding propensity (NBP), and evolutionary information combined with physicochemical properties (EIPP). The results showed that these novel features have important roles in improving the performance of the predictor. Using the mRMR-IFS method, our predictor achieved the best performance (86.62% accuracy and 0.737 Matthews correlation coefficient). High prediction accuracy and successful prediction performance suggested that our method can be a useful approach to identify RNA-binding proteins from sequence information.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Ma X,Guo J,Sun Xdoi
10.1155/2015/425810subject
Has Abstractpub_date
2015-01-01 00:00:00pages
425810eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/714230
更新日期:2015-01-01 00:00:00
abstract:Background:Waldenström macroglobulinemia (WM) is a rare, indolent B-cell lymphoma. Clinically, chromosome 6q deletion (6q del) including loss of the B lymphocyte-induced maturation protein 1 gene (BLIMP-1) is reported to be associated with poor prognosis. However, it remains unclear how the underlying biological mechan...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6728128
更新日期:2018-10-04 00:00:00
abstract::Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4375075
更新日期:2020-11-14 00:00:00
abstract::Sciatic nerve crush injury in rat animal model is one of the most common experimental models used in regenerative research. However, the availability of transgenic mouse for nerve regeneration studies is constantly increasing and, therefore, the shift from rat model to mouse model is, in some cases, necessary. Moreove...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/701682
更新日期:2014-01-01 00:00:00
abstract::Models using large animals that are suitable for studying artificial liver support system (ALSS) are urgently needed. Presently available acute liver failure (ALF) models mainly involve pigs or dogs. Establishment of current surgical ALF models (hepatectomy/devascularization) requires either very good surgical skills ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3518989
更新日期:2016-01-01 00:00:00
abstract:Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7147824
更新日期:2020-07-31 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2854736
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1892458
更新日期:2020-11-27 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/602871
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8609364
更新日期:2020-03-24 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8524972
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract:Background and Aims:The present study aimed to develop a simple and sensitive method for quantitative determination of monocrotaline (MCT) in mouse blood employing ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI/MS/MS) using rhynchophylline as an internal standard. Me...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1578643
更新日期:2018-08-13 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/496193
更新日期:2013-01-01 00:00:00
abstract:Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052143
更新日期:2020-08-13 00:00:00
abstract::Presynaptic and postsynaptic neurotoxins are proteins which act at the presynaptic and postsynaptic membrane. Correctly predicting presynaptic and postsynaptic neurotoxins will provide important clues for drug-target discovery and drug design. In this study, we developed a theoretical method to discriminate presynapti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3267325
更新日期:2017-01-01 00:00:00
abstract::Introduction. Patients with head and neck cancer suffer from various impairments due to the primary illness, as well as secondary consequences of the oncological treatment. This systematic review describes the effects of radiotherapy and/or chemotherapy on the functions of the upper aerodigestive tract in patients wit...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2016/6086894
更新日期:2016-01-01 00:00:00
abstract::Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and activates the unfolded protein response path...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5958272
更新日期:2020-01-27 00:00:00
abstract::The aim of this study was to evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) using warmed and nonwarmed miriplatin for hepatocellular carcinoma. Eighty patients (117 nodules), treated between January 2010 and June 2013, were evaluated. Thirty-two and 85 nodules were treated with non...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/359296
更新日期:2014-01-01 00:00:00
abstract::The variability in Helicobacter pylori vacA and cagA genes has been related to the progression of the gastrointestinal disease; also the presence of H. pylori in the oral cavity has been associated with periodontal disease in adults, but, in children without dyspeptic symptoms, little is known about this. We evaluated...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4923640
更新日期:2017-01-01 00:00:00
abstract::Persistent catecholamine-resistant shock in children causes severe morbidity and mortality. We aimed to analyze the association between hemodynamics and serum lactate at different time points and 28-day mortality in children with persistent catecholamine-resistant shock. Methods. Twenty-six children with persistent ca...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1341326
更新日期:2020-06-19 00:00:00
abstract::The aim of the study was to assess the prevalence of temporomandibular disorders (TMD) and oral parafunctions, as well as their correlation with psychoemotional factors in Polish university students. The research was conducted in a group of 456 students (N = 456). The examination form comprised of two parts: survey an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/472346
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5437139
更新日期:2017-01-01 00:00:00
abstract:Objective:The current study aimed to investigate the effects of body position on the level and severity of stuttering in young adults with developmental stuttering. Methods:A total of 24 subjects (male: 17; female: 7; mean age: 24.9 ± 6.2 years) with developmental stuttering participated. The participants were asked t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1817906
更新日期:2019-08-05 00:00:00
abstract::Local delivery of neurotrophic factors is a pillar of neural repair strategies in the peripheral nervous system. The main disadvantage of the free growth factors is their short half-life of few minutes. In order to prolong their activity, we have conjugated to iron oxide nanoparticles three neurotrophic factors: nerve...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/267808
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND AIM:Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elemen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/261761
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/236486
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2015/828120
更新日期:2015-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2014/169203.]. ...
journal_title:BioMed research international
pub_type: 已发布勘误
doi:10.1155/2020/9175369
更新日期:2020-09-07 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8695783
更新日期:2020-04-02 00:00:00