Assessment of morphological and functional changes in organs of rats after intramuscular introduction of iron nanoparticles and their agglomerates.

Abstract:

:The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were assessed after repeated intramuscular injections (total, 7) with preparation containing agglomerate of iron nanoparticles. As a result, iron depot was formed in myosymplasts of injection sites. The quantity of muscle fibers having positive Perls' stain increased with increasing number of injections. However, the concentration of the most chemical elements and iron significantly decreased in the whole skeletal muscle system (injection sites are not included). Consequently, it increased up to the control level after the sixth and the seventh injections. Among the studied organs (liver, kidneys, and spleen), Caspase-3 expression was revealed only in spleen. The expression had a direct dependence on the number of injections. Processes of iron elimination from preparation containing nanoparticles and their agglomerates had different intensity.

journal_name

Biomed Res Int

authors

Sizova E,Miroshnikov S,Yausheva E,Polyakova V

doi

10.1155/2015/243173

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

243173

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

杂志文章
  • Antilisterial Effect of Rosa damascena and Nymphaea alba in Mus musculus.

    abstract::The present study was proposed to investigate the toxicological and prophylactic potential of ethanolic extracts of Rosa damascena and Nymphaea alba and their mixture in albino mice. For toxicity study, three different doses of plant extracts were orally administrated to three groups of mice for 14 successive days. Bl...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/4543723

    authors: Batool R,Kalsoom A,Akbar I,Arshad N,Jamil N

    更新日期:2018-01-23 00:00:00

  • Identification and Validation of Prognostically Relevant Gene Signature in Melanoma.

    abstract:Background:Currently, effective genetic markers are limited to predict the clinical outcome of melanoma. High-throughput multiomics sequencing data have provided a valuable approach for the identification of genes associated with cancer prognosis. Method:The multidimensional data of melanoma patients, including clinic...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5323614

    authors: Gao Y,Li Y,Niu X,Wu Y,Guan X,Hong Y,Chen H,Song B

    更新日期:2020-05-08 00:00:00

  • Alzheimer's disease and HLA-A2: linking neurodegenerative to immune processes through an in silico approach.

    abstract::There is a controversial relationship between HLA-A2 and Alzheimer's disease (AD). It has been suggested a modifier effect on the risk that depends on genetic loadings. Thus, the aims of this study were to evaluate this relationship and to reveal genes associated with both concepts the HLA-A gene and AD. Consequently,...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/791238

    authors: Cifuentes RA,Murillo-Rojas J

    更新日期:2014-01-01 00:00:00

  • Physical Activity and Health-Related Fitness of Adolescents within the Juvenile Justice System.

    abstract:Background:The purpose of this study was to examine the physical activity patterns and health-related fitness levels of adolescents within the Juvenile Justice System. Methods:Participants included 68 adolescents (Mean age = 17.1 ± 1.0 years) in two secure Juvenile Justice correctional facilities in the Western USA. M...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2018/9710714

    authors: Brusseau TA,Burns RD,Hannon JC

    更新日期:2018-07-15 00:00:00

  • Modification of Mechanical Properties, Polymerization Temperature, and Handling Time of Polymethylmethacrylate Cement for Enhancing Applicability in Vertebroplasty.

    abstract::Polymethylmethacrylate (PMMA) bone cement is a popular bone void filler for vertebroplasty. However, the use of PMMA has some drawbacks, including the material's excessive stiffness, exothermic polymerization, and short handling time. This study aimed to create an ideal modified bone cement to solve the above-mentione...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/7901562

    authors: Tai CL,Lai PL,Lin WD,Tsai TT,Lee YC,Liu MY,Chen LH

    更新日期:2016-01-01 00:00:00

  • Triterpenes and the antimycobacterial activity of Duroia macrophylla Huber (Rubiaceae).

    abstract::Duroia macrophylla popularly known as "cabeça-de-urubú," "apuruí," or "puruí-grande-da-mata" occurs in the Amazon Forest. Its leaves and branches were collected twice and extracted with dichloromethane and methanol. All extracts were subjected to phytochemical investigation and terpenes and flavonoids were found in al...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/605831

    authors: Martins D,Carrion LL,Ramos DF,Salomé KS,da Silva PE,Barison A,Nunez CV

    更新日期:2013-01-01 00:00:00

  • Mediterranean spotted fever in southeastern Romania.

    abstract::Although cases of Mediterranean spotted fever (MSF) have been reported for decades in southeastern Romania, there are few published data. We retrospectively studied 339 patients, diagnosed with MSF at the National Institute of Infectious Diseases "Prof. Dr. Matei Bals" between 2000 and 2011, in order to raise awarenes...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/395806

    authors: Pitigoi D,Olaru ID,Badescu D,Rafila A,Arama V,Hristea A

    更新日期:2013-01-01 00:00:00

  • Noncoding RNAs Act as Tumor-Derived Molecular Components in Inducing Premetastatic Niche Formation.

    abstract::Cancer metastasis has been demonstrated as it is the culmination of a cascade of priming steps. Increasing evidence has shown that tumor-derived molecular components (TDMCs) are known as extra cellular vesicle and nonvesicle factors and serve as versatile intercellular communication vehicles which can mediate signalin...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2019/9258075

    authors: Zhang Z,Qiao J,Zhang D,Zhu W,Zhu J,Leng X,Li S

    更新日期:2019-06-12 00:00:00

  • Effects of 2,3,7,8-Tetrachlorodibenzo-p-dioxin on T Cell Differentiation in Primary Biliary Cholangitis.

    abstract::Exposure to dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is reported to affect the autoimmune system and increase the risk of autoimmune disease. Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR). Primary biliary cholangitis (PBC) is a chronic autoimmune disease, and its pathoge...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/1754975

    authors: She C,Wang J,Tang N,Liu Z,Xu L,Liu B

    更新日期:2020-08-24 00:00:00

  • Comparative Analysis and Classification of Cassette Exons and Constitutive Exons.

    abstract::Alternative splicing (AS) is a major engine that drives proteome diversity in mammalian genomes and is a widespread cause of human hereditary diseases. More than 95% of genes in the human genome are alternatively spliced, and the most common type of AS is the cassette exon. Recent discoveries have demonstrated that th...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/7323508

    authors: Cui Y,Cai M,Stanley HE

    更新日期:2017-01-01 00:00:00

  • Breast MRI in patients with unilateral bloody and serous-bloody nipple discharge: a comparison with galactography.

    abstract:PURPOSE:Assessing the role of breast MRI compared to galactography in patients with unilateral bloody or serous-bloody nipple discharge. MATERIALS AND METHODS:Retrospective study including 53 unilateral discharge patients who performed galactography and MRI. We evaluated the capability of both techniques in identifyin...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/806368

    authors: Manganaro L,D'Ambrosio I,Gigli S,Di Pastena F,Giraldi G,Tardioli S,Framarino M,Porfiri LM,Ballesio L

    更新日期:2015-01-01 00:00:00

  • Rotenone upregulates alpha-synuclein and myocyte enhancer factor 2D independently from lysosomal degradation inhibition.

    abstract::Dysfunctions of chaperone-mediated autophagy (CMA), the main catabolic pathway for alpha-synuclein, have been linked to the pathogenesis of Parkinson's disease (PD). Since till now there is limited information on how PD-related toxins may affect CMA, in this study we explored the effect of mitochondrial complex I inhi...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2013/846725

    authors: Sala G,Arosio A,Stefanoni G,Melchionda L,Riva C,Marinig D,Brighina L,Ferrarese C

    更新日期:2013-01-01 00:00:00

  • Bayesian Estimation of the True Prevalence and of the Diagnostic Test Sensitivity and Specificity of Enteropathogenic Yersinia in Finnish Pig Serum Samples.

    abstract::Bayesian analysis was used to estimate the pig's and herd's true prevalence of enteropathogenic Yersinia in serum samples collected from Finnish pig farms. The sensitivity and specificity of the diagnostic test were also estimated for the commercially available ELISA which is used for antibody detection against entero...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/931542

    authors: Vilar MJ,Ranta J,Virtanen S,Korkeala H

    更新日期:2015-01-01 00:00:00

  • The pilot study of fibrin with temporomandibular joint derived synovial stem cells in repairing TMJ disc perforation.

    abstract::TMJ disc related diseases are difficult to be cured due to the poor repair ability of the disc. TMJ-SDSCs were ideal cell sources for cartilage tissue engineering which have been widely used in hyaline cartilage regeneration. Fibrin gel has been demonstrated as a potential scaffold for neocartilage formation. The aim ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/454021

    authors: Wu Y,Gong Z,Li J,Meng Q,Fang W,Long X

    更新日期:2014-01-01 00:00:00

  • Markers of Alzheimer's Disease in Primary Visual Cortex in Normal Aging in Mice.

    abstract::Aging is the principal risk factor for the development of Alzheimer's disease (AD). The hallmarks of AD are accumulation of the amyloid-β peptide 1-42 (Aβ42) and abnormal hyperphosphorylation of Tau (p-Tau) protein in different areas of the brain and, more recently reported, in the visual cortex. Recently, Aβ42 peptid...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/3706018

    authors: Hernández-Zimbrón LF,Perez-Hernández M,Torres-Romero A,Gorostieta-Salas E,Gonzalez-Salinas R,Gulias-Cañizo R,Quiroz-Mercado H,Zenteno E

    更新日期:2017-01-01 00:00:00

  • A therapeutic strategy for spinal cord defect: human dental follicle cells combined with aligned PCL/PLGA electrospun material.

    abstract::Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/197183

    authors: Li X,Yang C,Li L,Xiong J,Xie L,Yang B,Yu M,Feng L,Jiang Z,Guo W,Tian W

    更新日期:2015-01-01 00:00:00

  • Intuitive web-based experimental design for high-throughput biomedical data.

    abstract::Big data bioinformatics aims at drawing biological conclusions from huge and complex biological datasets. Added value from the analysis of big data, however, is only possible if the data is accompanied by accurate metadata annotation. Particularly in high-throughput experiments intelligent approaches are needed to kee...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/958302

    authors: Friedrich A,Kenar E,Kohlbacher O,Nahnsen S

    更新日期:2015-01-01 00:00:00

  • Misleading Westerns: Common Quantification Mistakes in Western Blot Densitometry and Proposed Corrective Measures.

    abstract::Densitometry data generated for Western blots are commonly used to compare protein abundance between samples. In the last decade, it has become apparent that assumptions underpinning these comparisons are often violated in studies reporting Western blot data in the literature. These violations can lead to erroneous in...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/5214821

    authors: Butler TAJ,Paul JW,Chan EC,Smith R,Tolosa JM

    更新日期:2019-01-21 00:00:00

  • The use of hyaluronic acid after tendon surgery and in tendinopathies.

    abstract::Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2014/783632

    authors: Abate M,Schiavone C,Salini V

    更新日期:2014-01-01 00:00:00

  • Differential expression of immunogenic proteins on virulent Mycobacterium tuberculosis clinical isolates.

    abstract::Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response. Recent studies have demonstrated that Mtb fam...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/741309

    authors: Schierloh P,Klepp L,Vazquez C,Rocha RV,Blanco FC,Balboa L,López B,Ritacco V,Bigi F,Sasiain Mdel C

    更新日期:2014-01-01 00:00:00

  • Progressive Depletion of Rough Endoplasmic Reticulum in Epithelial Cells of the Small Intestine in Monosodium Glutamate Mice Model of Obesity.

    abstract::Chronic obesity is a known risk factor for metabolic syndrome. However, little is known about pathological changes in the small intestine associated with chronic obesity. This study investigated cellular and subcellular level changes in the small intestine of obese mice. In this study, a mouse model of obesity was est...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2016/5251738

    authors: Nakadate K,Motojima K,Hirakawa T,Tanaka-Nakadate S

    更新日期:2016-01-01 00:00:00

  • Identification and Expression Pattern of EZH2 in Pig Developing Fetuses.

    abstract::The proper methylation status of histones is essential for appropriate cell lineage and organogenesis. EZH2, a methyltransferase catalyzing H3K27me3, has been abundantly studied in human and mouse embryonic development. The pig is an increasing important animal model for molecular study and pharmaceutical research. Ho...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/5315930

    authors: Tan B,Hong L,Qiao J,Zhou J,Xing P,Yan G,Zheng E,Cai G,Huang S,Wu Z,Gu T

    更新日期:2020-10-05 00:00:00

  • Light Emitting Diode (LED) Phototherapy versus Conventional Phototherapy in Neonatal Hyperbilirubinemia: A Single Blinded Randomized Control Trial from Coastal India.

    abstract::Neonatal hyperbilirubinemia is a common problem with potentiality to cause irreversible brain damage. Reduction of serum bilirubin level is essential to minimize such damage. Compact fluorescent tubes, halogen bulbs, fiber optic blankets, and LEDs are commonly used light sources for phototherapy with varying efficacie...

    journal_title:BioMed research international

    pub_type: 杂志文章,随机对照试验

    doi:10.1155/2019/6274719

    authors: Gutta S,Shenoy J,Kamath SP,Mithra P,Baliga BS,Sarpangala M,Srinivasan M

    更新日期:2019-04-11 00:00:00

  • Pregnancy after acute coronary syndrome: a proposal for patients' management and a literature review.

    abstract::Coronary artery disease complicates only 0.01% of all pregnancies. For this reason, more exhaustive data on the management of such cases is lacking. Even guidelines on management of cardiovascular disease in pregnant women are scarce focusing mainly on acute myocardial infarction. This is a complex issue involving tho...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2013/957027

    authors: Janion-Sadowska A,Sadowski M,Kurzawski J,Zandecki L,Janion M

    更新日期:2013-01-01 00:00:00

  • Abdominal Wall Reconstruction after Flap Surgery and the Effect on the Immune System.

    abstract:Background:The aim of our study was to investigate the impact of abdominal wall reconstruction surgery on tissue anatomy and to explore how flap surgery influences the patient's immune status. Methods:Experimental abdominal wall defects were created in 8 Sus scrofa (swine) animal models. The animals were divided into ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2017/2421585

    authors: Popa F,Georgescu AV

    更新日期:2017-01-01 00:00:00

  • Nonalcoholic Fatty Liver Disease Aggravated the Severity of Acute Pancreatitis in Patients.

    abstract:Background and Aim:The incidence of nonalcoholic fatty liver disease (NAFLD) as a metabolic disease is increasing annually. In the present study, we aimed to explore the influence of NAFLD on the severity of acute pancreatitis (AP). Methods:The severity of AP was diagnosed and analyzed according to the 2012 revised At...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2019/9583790

    authors: Wu D,Zhang M,Xu S,Wu K,Wang N,Wang Y,Wu J,Lu G,Gong W,Ding Y,Xiao W

    更新日期:2019-01-22 00:00:00

  • Do We Pay Enough Attention to Culture Conditions in Context of Perinatal Outcome after In Vitro Fertilization? Up-to-Date Literature Review.

    abstract::Adverse perinatal outcomes in singleton IVF pregnancies have been most often explained by parental underlying diseases and so far laboratory conditions during embryo culture are still not explored well. The following review discusses the current state of knowledge on the influence of IVF laboratory procedures on the p...

    journal_title:BioMed research international

    pub_type: 杂志文章,评审

    doi:10.1155/2016/3285179

    authors: Marianowski P,Dąbrowski FA,Zyguła A,Wielgoś M,Szymusik I

    更新日期:2016-01-01 00:00:00

  • Long Noncoding RNA SNHG12 Promotes Prostate Tumor Occurrence and Progression via AKT Regulation.

    abstract::The small nucleolar RNA host gene 12 (SNHG12) has been reported to play an important role in the tumorigenesis and progression of PCa, but the functional underlying mechanism has not been studied clearly. We detected the expression level of SNHG12 in PCa tissues and matched adjacent normal tissues that were collected ...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2020/8812923

    authors: Chen Z,Qi T,Qin XP,Wang J,Huang ZS,Hu XY,Chen G,Qu LJ,Zhuo YM

    更新日期:2020-12-22 00:00:00

  • Outcome and prognostic factors in T4a oropharyngeal carcinoma, including the role of HPV infection.

    abstract:BACKGROUND:The prognosis of patients with advanced oropharyngeal carcinoma (OPSCC) is generally poor. The aim of this study is to investigate the different therapeutic approaches and identify prognostic factors associated with a worse outcome for patients treated for T4a OPSCC, in order to improve treatment selection f...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2014/390825

    authors: Psychogios G,Mantsopoulos K,Agaimy A,Brunner K,Mangold E,Zenk J,Iro H

    更新日期:2014-01-01 00:00:00

  • Improvement of D-Ribose Production from Corn Starch Hydrolysate by a Transketolase-Deficient Strain Bacillus subtilis UJS0717.

    abstract::D-Ribose is a five-carbon sugar and generally used as an energy source to improve athletic performance and the ability. The culture conditions for maximum D-ribose production performance from cheap raw material corn starch hydrolysate were improved by using one-factor-at-a-time experiments and a three-level Box-Behnke...

    journal_title:BioMed research international

    pub_type: 杂志文章

    doi:10.1155/2015/535097

    authors: Wei Z,Zhou J,Sun W,Cui F,Xu Q,Liu C

    更新日期:2015-01-01 00:00:00