Abstract:
:Despite remarkable therapeutic advances have been made in the last few decades, non-small cell lung cancer (NSCLC) is still one of the leading causes of death worldwide. Brain metastases are a common complication of a wide range of human malignancies and in particular NSCLC. Brain-derived neurotrophic factor (BDNF), binding its high-affinity tyrosine kinase B receptor, has been shown to promote cancer progression and metastasis. We hereby investigated the expression of the BDNF and its TrkB receptor in its full-length and truncated isoform T1, in samples from primary adenocarcinomas (ADKs) of the lung and in their metastasis to evaluate if their expression was related to preferential tumor entry into the central nervous system (CNS). By immunohistochemistry, 80% of the ADKs that metastasize to central nervous system expressed TrkB receptor compared to 33% expressing of ADKs without CNS metastasis. Moreover, ADKs with CNS metastasis showed an elevated expression of the full-length TrkB receptor. The TrkB receptor FL/T1 ratio was statistically higher in primary ADKs with brain metastasis compared to ADKs without brain metastasis. Our data indicate that TrkB full-length isoform expression in primary ADK cells may be associated with higher risk to develop brain metastasis. Therefore, TrkB receptor may possess prognostic and therapeutic implications in lung ADK.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Lombardi M,D'Ascanio M,Scarpino S,Scozzi D,Giordano M,Costarelli L,Raj ER,Mancini R,Cardillo G,Cardaci V,Innammorato M,Vecchione A,Ricci Adoi
10.1155/2020/4193541subject
Has Abstractpub_date
2020-11-17 00:00:00pages
4193541eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::Growing evidence suggests that increased arginase activity affects vital bioprocesses in various systems and universally mediates the pathogenesis of numerous metabolic diseases. The adverse effects of arginase are associated with a severe decline in L-arginine bioavailability, which leads to nitric oxide synthase sub...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4935386
更新日期:2020-02-12 00:00:00
abstract::Exposure to a variety of environmental factors such as salinity, drought, metal toxicity, extreme temperature, air pollutants, ultraviolet-B (UV-B) radiation, pesticides, and pathogen infection leads to subject oxidative stress in plants, which in turn affects multiple biological processes via reactive oxygen species ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9732325
更新日期:2019-05-08 00:00:00
abstract::Alpha-linolenic acid (ALA) is plant-based essential omega-3 polyunsaturated fatty acids that must be obtained through the diet. This could explain in part why the severe deficiency in omega-3 intake pointed by numerous epidemiologic studies may increase the brain's vulnerability representing an important risk factor i...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/519830
更新日期:2015-01-01 00:00:00
abstract::Nonlinear contrast-enhanced ultrasound imaging schemes strive to suppress tissue signals in order to better visualize nonlinear signals from blood-pooling ultrasound contrast agents. Because tissue does not generate a subharmonic response (i.e., signal at half the transmit frequency), subharmonic imaging has been prop...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/640397
更新日期:2015-01-01 00:00:00
abstract::Neoadjuvant radio(chemo)therapy is increasingly used in rectal cancer and induces a number of morphologic changes that affect prognostication after curative surgery, thereby creating new challenges for surgical pathologists, particularly in evaluating morphologic changes and tumour response to preoperative treatment. ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/574540
更新日期:2015-01-01 00:00:00
abstract:Introduction:The aim of this research was to test, in an animal model, the nerve regeneration technique with a hypoallergenic acellular dermal matrix used to wrap the microsurgical neural suture. Materials and Methods:Two groups of rats received the cut of limb right median nerves. The regeneration technique considers...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4750624
更新日期:2019-06-17 00:00:00
abstract::Molecular epidemiology has revealed that Mycobacterium tuberculosis (Mtb), formerly regarded as highly conserved species, displays a considerable degree of genetic variability that can influence the outcome of the disease as well as the innate and adaptive immune response. Recent studies have demonstrated that Mtb fam...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/741309
更新日期:2014-01-01 00:00:00
abstract::The craniofacial complex is the billboard of sorts containing information about sex, health, ancestry, kinship, genes, and environment. A thorough knowledge of the genes underlying craniofacial morphology is fundamental to understanding craniofacial biology and evolution. These genes can also provide an important foun...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/3054578
更新日期:2016-01-01 00:00:00
abstract:Objectives:To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods:We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2854186
更新日期:2020-09-23 00:00:00
abstract:Objective:To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method:We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/1709415
更新日期:2020-03-03 00:00:00
abstract:Purpose:Coconut water has long been touted for its medicinal qualities including natural hydration. We sought to determine whether its consumption would induce changes to urinary lithogenic factors beyond changes in urine volume. Materials and Methods:After Institutional Review Board approval, volunteers with no prior...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3061742
更新日期:2018-11-01 00:00:00
abstract::Reactive oxygen species (ROS) damage macromolecules and cellular components in nearly all kinds of cells and often generate toxic intracellular byproducts. In this work, aldehyde generation derived from the Escherichia coli membrane oxidation as well as membrane fatty acid profiles, protein oxidation, and bacterial re...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/563756
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to offer a new insight into the microstructure changes during in vitro lipolysis of five lipid-based drug delivery formulations belonging to different lipid formulation types. Five lipid-based formulations of indomethacin were investigated using an in vitro lipolysis model. During lipolys...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2364317
更新日期:2016-01-01 00:00:00
abstract::The complexity and diversity of eukaryotic organisms are a feat of nature's engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/407263
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:This study investigates the safety and efficacy of a multimodality approach combining staged endovascular embolizations with subsequent SRS for the management of larger AVMs. METHODS:Ninety-five patients with larger AVMs were treated with staged endovascular embolization followed by SRS between 1996 and 2011...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/306518
更新日期:2014-01-01 00:00:00
abstract::As a major tumor suppressor gene, the role of PinX1 in breast cancer and its molecular mechanism remain unclear. In this study, overexpression of PinX1 was generated in 3 breast cancer cell lines, and knockdown of PinX1 was performed in a nontumorigenic breast cell line. The regulation of PinX1 on cell proliferation a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/978984
更新日期:2014-01-01 00:00:00
abstract:Objective:To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis. Methods:A total of 76 women were included in this study, 42 with adenomyosis (proliferative phase, n = 23; secre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5974693
更新日期:2017-01-01 00:00:00
abstract::GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/648108
更新日期:2015-01-01 00:00:00
abstract::Viral infections result in millions of deaths in the world today. A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies. In this study, we presented a landscape of virus-host interactomes based on protein domain interaction. Compared to the analysis at protei...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867235
更新日期:2014-01-01 00:00:00
abstract::Lung illness encountered in patients with rheumatic diseases bears clinical significance in terms of increased morbidity and mortality as well as potential challenges placed on patient care. Although our understanding of natural history of this important illness is still limited, epidemiologic knowledge has been accum...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/6930297
更新日期:2018-05-08 00:00:00
abstract::Natural products are valuable sources for drug discovery because they have a wide variety of useful chemical components and biological properties. A quick reevaluation of the potential therapeutic properties of established natural products was made possible by the recent development of the methodology and improvement ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6716547
更新日期:2018-08-01 00:00:00
abstract::Butyrate produced by the intestinal microbiota is essential for proper functioning of the intestinal immune system. Total dependence on parenteral nutrition (PN) is associated with numerous adverse effects, including severe microbial dysbiosis and loss of important butyrate producers. We hypothesised that a lack of bu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7084734
更新日期:2019-02-28 00:00:00
abstract::Human adipose-derived stem cells (hASCs) are an attractive cell source for therapeutic applicability in diverse fields for the repair and regeneration of damaged or malfunctioning tissues and organs. There is a growing number of cell therapies using stem cells due to their characteristics of modulation of immune syste...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/143504
更新日期:2015-01-01 00:00:00
abstract::Until now, the chemical bonding between titanium and bone has been examined only through a few mechanical detachment tests. Therefore, in this study, a sandblasted and acid-etched titanium mini-implant was removed from a human patient after 2 months of placement in order to identify the chemical integration mechanism ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/960410
更新日期:2015-01-01 00:00:00
abstract::WHO reported that adherence among patients with chronic diseases averages only 50% in developed countries. This is recognized as a significant public health issue, since medication nonadherence leads to poor health outcomes and increased healthcare costs. Improving medication adherence is, therefore, crucial and revea...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/217047
更新日期:2015-01-01 00:00:00
abstract::Viscosupplementation with hyaluronic acid is safe and effective in the management of osteoarthritis, but its use in the treatment of tendon disorders has received less attention. The aim of this review is to summarize the current knowledge on this topic, evaluating experimental and clinical trials. A search of English...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/783632
更新日期:2014-01-01 00:00:00
abstract::Bioadhesive nasal dosage forms are an attractive method for overcoming rapid mucociliary clearance transport in the nose and for delivering the drug directly to brain. The present study was designed to formulate chondroitin sulphate (CS) and chitosan (CH) nasal inserts employing zolmitriptan, an antimigraine drug. The...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/958465
更新日期:2013-01-01 00:00:00
abstract:Objective:Biomaterial research for soft tissue augmentation is an increasing topic in aesthetic medicine. Hyaluronic acid (HA) fillers are widely used for their low invasiveness and easy application to correct aesthetic defects or traumatic injuries. Some complications as acute or chronic inflammation can occur in pati...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8676343
更新日期:2020-05-21 00:00:00
abstract:OBJECTIVE:To evaluate HIV risk perception and its associated factors among Chinese MSM. METHODS:A cross-sectional study was conducted among MSM with an HIV negative or unknown status in Beijing, China, between 2011 and 2012. A questionnaire interview was conducted and a blood sample was collected for HIV and syphilis ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/232451
更新日期:2014-01-01 00:00:00
abstract::Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability fac...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/180468
更新日期:2014-01-01 00:00:00