Abstract:
:Viral infections result in millions of deaths in the world today. A thorough analysis of virus-host interactomes may reveal insights into viral infection and pathogenic strategies. In this study, we presented a landscape of virus-host interactomes based on protein domain interaction. Compared to the analysis at protein level, this domain-domain interactome provided a unique abstraction of protein-protein interactome. Through comparisons among DNA, RNA, and retrotranscribing viruses, we identified a core of human domains, that viruses used to hijack the cellular machinery and evade the immune system, which might be promising antiviral drug targets. We showed that viruses preferentially interacted with host hub and bottleneck domains, and the degree and betweenness centrality among three categories of viruses are significantly different. Further analysis at functional level highlighted that different viruses perturbed the host cellular molecular network by common and unique strategies. Most importantly, we creatively proposed a viral disease network among viral domains, human domains and the corresponding diseases, which uncovered several unknown virus-disease relationships that needed further verification. Overall, it is expected that the findings will help to deeply understand the viral infection and contribute to the development of antiviral therapy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zheng LL,Li C,Ping J,Zhou Y,Li Y,Hao Pdoi
10.1155/2014/867235subject
Has Abstractpub_date
2014-01-01 00:00:00pages
867235eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::The treatment of traumatic low-degree vertebral compression fracture remains in a wide range between functional treatment, bracing, vertebroplasty, kyphoplasty, and even surgical fixation. The objective was to assess the innovation of instrumented kyphoplasty and to report the early and mid-term functional and radiolo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1386510
更新日期:2019-12-10 00:00:00
abstract::The aim of this study is to inform about the development of a new semispherical surgical instrument for the bipolar multielectrode radiofrequency liver ablation. Present tools are universal; however they have several disadvantages such as ablation of healthy tissue, numerous needle punctures, and, therefore, longer op...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/532792
更新日期:2014-01-01 00:00:00
abstract::Heavy metals have the potential to interact and induce several stress responses in the plants; thus, effects of heavy metal stress on DNA damages and total antioxidants level in Urtica dioica leaves and stems were investigated. The samples are sampled from areas with different metal exposition. Metal content was analy...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/276417
更新日期:2013-01-01 00:00:00
abstract::An FDA-regulated, prescription medical food (Fosteum; 27 mg natural genistein, 200 IU cholecalciferol, 20 mg citrated zinc bisglycinate (4 mg elemental zinc) per capsule) and an over-the-counter (OTC) supplement (Citracal Plus Bone Density Builder; 27 mg synthetic genistein, 600 mg elemental calcium (calcium citrate),...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2013/273498
更新日期:2013-01-01 00:00:00
abstract:Background:Diagnosis using reliable tools and treatment following in vitro antimicrobial susceptibility tests are critical to proper addressing of antibiotic-resistant Salmonella infection. Methodology:A cross-sectional study was conducted to assess the practice of diagnosis and treatment of salmonellosis in Addis Aba...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6406405
更新日期:2018-05-23 00:00:00
abstract:Materials and Methods:Various aqueous extracts were prepared from this plant and preadministered per os to albino mice 3 h before APAP administration, once daily for one week. Animals from the normal group were given only distilled water while those from negative control received only APAP 250 mg/kg. After treatment, m...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3807234
更新日期:2020-08-31 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/371063
更新日期:2013-01-01 00:00:00
abstract::The presence of acquired mutations within the JAK2, CALR, and MPL genes in the majority of patients with myeloproliferative neoplasms (MPN) affords the opportunity to utilise these mutations as markers of minimal residual disease (MRD). Reduction of the mutated allele burden has been reported in response to a number o...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2016/7241591
更新日期:2016-01-01 00:00:00
abstract::One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3967427
更新日期:2020-12-04 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5341247
更新日期:2020-06-30 00:00:00
abstract::The characteristics of FDG uptake in the physiologic and malignant nasopharynx were investigated in the paper which was correlated with either pathologic findings or clinical follow-up. Three patients had pathologically established nasopharyngeal malignancy. In the 3 nasopharyngeal malignancies, 2 had diffusely and ex...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/354970
更新日期:2015-01-01 00:00:00
abstract::The aims of this work were to evaluate the in vitro and in vivo schistosomicidal properties of the methanolic extract of the aerial parts of Mitracarpus frigidus (MFM) and to determine its HPLC profile. For the in vitro experiment, four pairs of adult worms, obtained from infected mice, were exposed to different conce...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/941318
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/742646
更新日期:2015-01-01 00:00:00
abstract::N6-methyladenosine (m6A) plays an important role in many cancers. However, few studies have examined the role of m6A in colorectal CRC. To examine the effect of m6A on CRC, we studied the genome of 591 CRC cases from The Cancer Genome Atlas (TCGA). The relationship between the messenger RNA (mRNA) expression, copy num...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8826456
更新日期:2020-12-19 00:00:00
abstract:Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/9853701
更新日期:2019-05-13 00:00:00
abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/356427
更新日期:2014-01-01 00:00:00
abstract::The regulation of transcriptome expression level is a complex process involving multiple-level interactions among molecules such as protein coding RNA (mRNA), long noncoding RNA (lncRNA), and microRNA (miRNA), which are essential for the transcriptome stability and maintenance and regulation of body homeostasis. The a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3859582
更新日期:2017-01-01 00:00:00
abstract::It has been indicated that activation of peripheral imidazoline I2-receptor (I-2R) may reduce the blood pressure in spontaneously hypertensive rats (SHRs). Also, guanidinium derivatives show the ability to activate imidazoline receptors. Thus, it is of special interest to characterize the I-2R using guanidinium deriva...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/182846
更新日期:2014-01-01 00:00:00
abstract::The acute toxicity, the antioxidant activity, and the pharmacological activity on the gastrointestinal tract of rodents of the ethanolic extract (TFEE) from the bark of Terminalia fagifolia Mart. & Zucc. (Combretaceae) and of its aqueous (TFAqF), hydroalcoholic (TFHAF), and hexanic (TFHEXF) partition fractions have be...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/261745
更新日期:2014-01-01 00:00:00
abstract::Any bioassay to test new chemically synthesized larvicides or phytolarvicides against Culicidae and more harmful mosquito species, such as Aedes aegypti and Aedes albopictus, which specifically transmit dengue, yellow fever, chikungunya viral fevers as well as Zika virus, or Anopheles gambiae, a vector for malaria and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7405421
更新日期:2020-08-29 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/759361
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/2150159
更新日期:2019-07-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1618527
更新日期:2020-02-14 00:00:00
abstract::Tumourigenesis is a mutation accumulation process, which is likely to start with a mutated founder cell. The evolutionary nature of tumor development makes phylogenetic models suitable for inferring tumor evolution through genetic variation data. Copy number variation (CNV) is the major genetic marker of the genome wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5482750
更新日期:2017-01-01 00:00:00
abstract::The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controve...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/3571861
更新日期:2017-01-01 00:00:00
abstract::The present study was designed to evaluate the cardioprotective effect of sesamol against doxorubicin-induced cardiomyopathy in rats. In this study, the cardioprotective effect of sesamol against doxorubicin induced cardiomyopathy in experimental rats was evaluated at the dosage of 50 mg/kg bw. Doxorubicin was adminis...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/934239
更新日期:2013-01-01 00:00:00
abstract::The incidence and rates of diagnosis of drug-induced liver injury (DILI) have been increasing in recent years as findings from basic research and the examination of clinical databases reveal information about the clinical course, etiology, and prognosis of this complex disease. The prevalence of metabolic comorbiditie...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/8764093
更新日期:2019-08-18 00:00:00
abstract::The purpose of the study is to evaluate the relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional and multicenter survey was conducted from July 2012 to January 2014. Men were recruited from urology clinics which were located at the five cities in China. All men participated in ...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究
doi:10.1155/2015/560239
更新日期:2015-01-01 00:00:00
abstract::Different animal models for peritoneal dialysis (PD) have been used in the past decades to develop PD fluids compatible with patient life and to identify markers of peritoneal fibrosis and inflammation. Only few of those studies have taken into account the importance of uraemia-induced alterations at both systemic and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/106902
更新日期:2015-01-01 00:00:00
abstract::Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/782625
更新日期:2014-01-01 00:00:00