Abstract:
:The incidence and rates of diagnosis of drug-induced liver injury (DILI) have been increasing in recent years as findings from basic research and the examination of clinical databases reveal information about the clinical course, etiology, and prognosis of this complex disease. The prevalence of metabolic comorbidities (e.g., diabetes mellitus, fatty liver, obesity, and metabolic syndrome (MetS)) has been increasing during the same period. The results of preclinical and clinical research studies indicate that characteristics of metabolic comorbidities are also factors that affect DILI phenotype and progression. The objective of this review is to present the evidence for DILI and hepatotoxicity mechanisms, incidence, and outcomes in patients with MetS and nonalcoholic fatty liver disease. Moreover, we also summarize the relationships between drugs used to treat metabolic comorbidities and DILI.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Li X,Gao P,Niu Jdoi
10.1155/2019/8764093subject
Has Abstractpub_date
2019-08-18 00:00:00pages
8764093eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章,评审abstract::It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/214618
更新日期:2015-01-01 00:00:00
abstract::The present study deals with the enzymatic synthesis of biodiesel by transesterification of Jatropha oil (Jatropha curcas L.) with ethanol in a solvent-free system. Seven commercial lipase preparations immobilized by covalent attachment on epoxy-polysiloxane-polyvinyl alcohol composite (epoxy-SiO2-PVA) were tested as ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1404567
更新日期:2016-01-01 00:00:00
abstract::After pancreatoduodenectomy, complication rates are up to 40%. To predict the risk of developing postoperative pancreatic fistula or severe complications, various factors were evaluated. 110 consecutive patients undergoing pancreatoduodenectomy at our institute between January 2012 and September 2014 with complete CT ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/824525
更新日期:2015-01-01 00:00:00
abstract::Aim. To investigate the expression of miR-940 in the hepatocellular carcinoma (HCC) and its impact on function and biological mechanism in the HCC cells. Methods. Quantitative RT-PCR analysis was used to quantify miR-940 expression in 46 cases of tissues and cells. Transfection of HCC cell lines was performed by miR-9...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7618342
更新日期:2016-01-01 00:00:00
abstract:Background:Musculoskeletal disorders (MSDs) are considered one of the most common health issues in working population and have a high social and economic impact. This study is aimed at determining the MSD patterns and associated risk factors among higher education academicians in Saudi Arabia. Methods:A cross-sectiona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8930968
更新日期:2020-08-15 00:00:00
abstract::Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity inv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367939
更新日期:2014-01-01 00:00:00
abstract::The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe dr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/857327
更新日期:2015-01-01 00:00:00
abstract::This study investigated the effects of a pragmatic lifestyle intervention in obese adults with continuous positive airway pressure-treated obstructive sleep apnoea hypopnoea syndrome (OSAHS). Sixty patients were randomised 1 : 1 to either a 12-week lifestyle intervention or an advice-only control group. The interventi...
journal_title:BioMed research international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1155/2014/102164
更新日期:2014-01-01 00:00:00
abstract::To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/360687
更新日期:2014-01-01 00:00:00
abstract::Macleaya cordata extract is of great scientific and practical interest to researchers, due to its antimicrobial and anti-inflammatory responses within experimental animals. This study was designed to determine the diarrhea score and innate immunity of growing piglets after they had received Macleaya cordata extract su...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1069585
更新日期:2016-01-01 00:00:00
abstract::Healthcare professionals undergo high levels of occupational stress as a result of their working conditions. Thus, the aim of this study is to develop a model that focuses on healthcare professionals so as to analyze the influence that job demands, control, social support, and recognition have on the likelihood that a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4673047
更新日期:2017-01-01 00:00:00
abstract::The availability of fluorescent dyes and the advances in the optical systems for in vivo imaging have stimulated an increasing interest in developing new methodologies to study and quantify the biodistribution of labeled agents. However, despite these great achievements, we are facing significant challenges in determi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/196837
更新日期:2014-01-01 00:00:00
abstract:Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/9853701
更新日期:2019-05-13 00:00:00
abstract:Objective:We compared the prostate cancer (PCa) detection rates of targeted biopsy (TB) and saturation biopsy (SB) in patients with previous negative biopsy and the accuracy of TB and SB stratified by different serum prostate-specific antigen (PSA) levels. Materials and Methods:Overall 185 patients were enrolled. In t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7617148
更新日期:2017-01-01 00:00:00
abstract::There is a controversial relationship between HLA-A2 and Alzheimer's disease (AD). It has been suggested a modifier effect on the risk that depends on genetic loadings. Thus, the aims of this study were to evaluate this relationship and to reveal genes associated with both concepts the HLA-A gene and AD. Consequently,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/791238
更新日期:2014-01-01 00:00:00
abstract::Contrast enhanced magnetic resonance imaging (CE-MRI) has acquired a central role in the field of diagnosis and evaluation of breast cancer due to its high sensitivity; on the other hand, MRI has shown a variable specificity because of the wide overlap between the imaging features of benign and malignant lesions. Ther...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/3896946
更新日期:2018-10-21 00:00:00
abstract:PURPOSE:The primary aim of this study was to explore if classification, whether using the BI-RADS categories based on CEUS or conventional ultrasound, was conducive to the identification of benign and malignant category 3 or 4 small breast lesions. MATERIAL AND METHODS:We evaluated 30 malignant and 77 benign small bre...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2014/572532
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2017/6353510.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2018/5189346
更新日期:2018-09-26 00:00:00
abstract::Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb, i.e., the aetiological agent); the WHO has established this disease as high priority due to its ensuing mortality. Mtb uses a range of mechanisms for preventing its elimination by an infected host; new, viable alternatives for blocking th...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8680935
更新日期:2019-04-14 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease and its targeting of the joints indicates the presence of a candidate autoantigen(s) in synovial joints. Patients with RA show immune responses in their peripheral blood to proteoglycan (PG) aggrecan. One of the most relevant animal models of RA appears to be ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/942148
更新日期:2014-01-01 00:00:00
abstract:Objective:Delays in skeletal maturity are related to bone mass and fracture risk in children, but the factors that determine it are unknown. We aimed to identify the association between insulin-like growth factor-1 (IGF-1) and skeletal maturation before and after growth hormone (GH) treatment. Methods:In this retrospe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8052143
更新日期:2020-08-13 00:00:00
abstract::Parkinson's disease (PD) is a major neurodegenerative disorder for which the etiology and pathogenesis remain as elusive as for Alzheimer's disease. PD appears to be caused by genetic and environmental factors, and pedigree and cohort studies have identified numerous susceptibility genes and loci related to PD. Autoso...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/371256
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Histones play important roles in both host defenses and inflammation related to microbial infection. A peptide mimotope (SSV) was identified from a novel histone H1 monoclonal antibody (16G9 mAb) that was shown to inhibit the mixed lymphocyte reaction. In the present study, an anti-SSV producing hybridoma wa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/491649
更新日期:2015-01-01 00:00:00
abstract::Effects of in ovo injection of Q10 on hatchability, performance (feed intake (FI), body weight gain (BWG), feed/gain ratio (F/G)) traits, and immune status of Ross × Ross 308 broiler chicks, hatched from eggs laid by a 38-week-old breeder flock, were determined through 42 days after hatch. Eggs containing live embryos...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/7167525
更新日期:2019-02-04 00:00:00
abstract::Legumes have developed a unique way to interact with bacteria: in addition to preventing infection from pathogenic bacteria like any other plant, legumes also developed a mutualistic symbiotic relationship with one gender of soil bacteria: rhizobium. This interaction leads to the development of a new root organ, the n...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/507946
更新日期:2014-01-01 00:00:00
abstract::The cyprinid genus Pteronotropis is endemic to southeastern Gulf of Mexico and Atlantic Ocean of North America. Never before has the genus been demonstrated to be monophyletic. We investigate both the phylogenetic relationships and the phylogeography of some species in the genus using mitochondrial ND2 sequences. In n...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/675260
更新日期:2015-01-01 00:00:00
abstract::Although considerable progress has been made in the management of patients with invasive fungal infections, Candida bloodstream infections are still widespread in hospital settings. Incidence rates vary geographically, often because of different patient populations. The aim of the present study was to describe the epi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/256580
更新日期:2015-01-01 00:00:00
abstract:INTRODUCTION:Spectroscopic analysis of urine samples from laboratory animals can be used to predict the efficacy and side effects of drugs. This employs methods combining (1)H NMR spectroscopy with quantification of biomarkers or with multivariate data analysis. The most critical steps in data evaluation are analytical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/878374
更新日期:2013-01-01 00:00:00
abstract:Objective:Study the effect of quality control circle (QCC) in promoting the usage of rubber dams (RD) in root canal treatment of chronic pulpitis in primary teeth. Methods:Set up a quality control group to increase the amount of rubber dams used in the treatment of chronic pulpitis in primary teeth. Monthly monitoring...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5397838
更新日期:2020-02-24 00:00:00