Alzheimer's disease and HLA-A2: linking neurodegenerative to immune processes through an in silico approach.

abstract：:Electrospun scaffolds provide a dense framework of nanofibers with pore sizes and fiber diameters that closely resemble the architecture of native extracellular matrix. However, it generates limited three-dimensional structures of relevant physiological thicknesses. 3D printing allows digitally controlled fabrication ...

journal_title：BioMed research international

authors： Mellor LF,Huebner P,Cai S,Mohiti-Asli M,Taylor MA,Spang J,Shirwaiker RA,Loboa EG

更新日期：2017-01-01 00:00:00

abstract：:The different techniques and methods employed as well as the different quantitative and qualitative variables measured in order to objectify postural control are often chosen without taking into account the population studied, the objective of the postural test, and the environmental conditions. For these reasons, the...

journal_title：BioMed research international

authors： Paillard T,Noé F

更新日期：2015-01-01 00:00:00

abstract：:Sericin is a natural protein component of silks of silkworm and has potential utility in multiple areas such as pharmacological, cosmetics, and biotechnological industries. However, the understanding of its toxicological safety is still limited. This study evaluated the safety of water-extract sericin from silkworm (B...

journal_title：BioMed research international

authors： Qin H,Zhang J,Yang H,Yao S,He L,Liang H,Wang Y,Chen H,Zhao P,Qin G

更新日期：2020-11-05 00:00:00

abstract：:Preeclampsia (PE) is a unique complication of pregnancy, the pathogenesis of which has been generally accepted to be associated with the dysfunctions of extravillous trophoblast (EVT) including proliferation, apoptosis, and migration and invasion. Decorin (DCN) has been proved to be a decidua-derived TGF-binding prote...

journal_title：BioMed research international

authors： Zou Y,Yu X,Lu J,Jiang Z,Zuo Q,Fan M,Huang S,Sun L

更新日期：2015-01-01 00:00:00

abstract：:This study included 30 patients with diagnosed rheumatoid arthritis (RA) and 30 test subjects without RA (control group). The objective of the study was to examine both groups for the presence of temporomandibular disorders (TMD) and morphological changes of the temporomandibular joint (TMJ). All individuals were exam...

journal_title：BioMed research international

authors： Witulski S,Vogl TJ,Rehart S,Ottl P

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Over the past decade, image quality in low-dose computed tomography has been greatly improved by various compressive sensing- (CS-) based reconstruction methods. However, these methods have some disadvantages including high computational cost and slow convergence rate. Many different speed-up t...

journal_title：BioMed research international

authors： Huang HM,Hsiao IT

更新日期：2017-01-01 00:00:00

abstract：:The objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration. The study involved 27 Wistar rats that were divided into five groups. On Day 1, both knees of 3 rats were resected and placed in a formalin so...

journal_title：BioMed research international

authors： Gokay NS,Yilmaz I,Komur B,Demiroz AS,Gokce A,Dervisoglu S,Gokay BV

更新日期：2016-01-01 00:00:00

abstract：:Diabetic patients are at risk for spontaneous foot ulcers, chronic wounds, infections, and tissue necrosis. Current theories suggest that the development and progression of diabetic foot ulcers are mainly caused by arteriosclerosis and peripheral neuropathy. Tissue necrosis plays a primordial role in the progression o...

journal_title：BioMed research international

authors： Lévigne D,Tobalem M,Modarressi A,Pittet-Cuénod B

更新日期：2013-01-01 00:00:00

abstract：:The epilepsies are a heterogeneous group of neurological disorders and syndromes characterised by recurrent, involuntary, paroxysmal seizure activity, which is often associated with a clinicoelectrical correlate on the electroencephalogram. The diagnosis of epilepsy is usually made by a neurologist but can be difficul...

journal_title：BioMed research international

authors： Fergus P,Hignett D,Hussain A,Al-Jumeily D,Abdel-Aziz K

更新日期：2015-01-01 00:00:00

abstract：:Engineering three-dimensional (3D) vascularized constructs remains a challenge due to the inability to form rich microvessel networks. In this study we engineered a prevascularized 3D cell sheet construct for tissue regeneration using human bone marrow-derived mesenchymal stem cells (hMSCs) and human umbilical vein en...

journal_title：BioMed research international

authors： Ren L,Ma D,Liu B,Li J,Chen J,Yang D,Gao P

更新日期：2014-01-01 00:00:00

abstract：:The potential of three submerged aquatic plant species (Cabomba piauhyensis, Egeria densa, and Hydrilla verticillata) to be used for As, Al, and Zn phytoremediation was tested. The plants were exposed for 14 days under hydroponic conditions to mine waste water effluents in order to assess the suitability of the aquati...

journal_title：BioMed research international

authors： Abu Bakar AF,Yusoff I,Fatt NT,Othman F,Ashraf MA

更新日期：2013-01-01 00:00:00

abstract：:The pathogenesis of intractable epilepsy is not fully clear. In recent years, both animal and clinical trials have shown that the expression of ATP-binding cassette (ABC) transporters is increased in patients with intractable epilepsy; additionally, epileptic seizures can lead to an increase in the number of sites tha...

journal_title：BioMed research international

authors： Xiong J,Mao DA,Liu LQ

更新日期：2015-01-01 00:00:00

abstract：:Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity inv...

journal_title：BioMed research international

authors： Dayaratne MW,Vlajkovic SM,Lipski J,Thorne PR

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. METHODS:Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic ...

journal_title：BioMed research international

authors： Özdemir B,Emül A,Özdemir L,Sağ S,Biçer M,Aydınlar A

更新日期：2015-01-01 00:00:00

abstract：:Aim. To investigate the expression of miR-940 in the hepatocellular carcinoma (HCC) and its impact on function and biological mechanism in the HCC cells. Methods. Quantitative RT-PCR analysis was used to quantify miR-940 expression in 46 cases of tissues and cells. Transfection of HCC cell lines was performed by miR-9...

journal_title：BioMed research international

authors： Ding D,Zhang Y,Yang R,Wang X,Ji G,Huo L,Shao Z,Li X

更新日期：2016-01-01 00:00:00

abstract：INTRODUCTION:Cerebral emboli may occur in subarachnoid hemorrhage (SAH) and intracranial aneurysm surgery. Although embolic signs (ES) have been reported in SAH, their origin remains unclear. The aim of this study was to report the detection of ES during routine TCD monitoring in patients with aneurysmal SAH. METHODS:...

journal_title：BioMed research international

authors： Paschoal FM Jr,de Almeida Lins Ronconi K,de Lima Oliveira M,Nogueira Rde C,Paschoal EH,Teixeira MJ,Figueiredo EG,Bor-Seng-Shu E

更新日期：2015-01-01 00:00:00

abstract：:Canine mammary gland tumor (CMT) is the most common tumor in intact female dog. Zerumbone (ZER) has promising anticancer properties, but plagued with poor water solubility, poor absorption, bioavailability, and delivery to target tissues. To solubilize, ZER was loaded into nanostructured lipid carrier (NLC) to produce...

journal_title：BioMed research international

authors： Foong JN,Selvarajah GT,Rasedee A,Rahman HS,How CW,Beh CY,Teo GY,Ku CL

更新日期：2018-10-15 00:00:00

abstract：Introduction:The sources of Reactive Oxidative Species (ROS) in the organism are the respiratory processes occurring in cells catalyzed by different enzymes. Operation of ROS is balanced by antioxidants, the compounds; although present in low concentrations, they significantly inhibit the degree of oxidation of particu...

journal_title：BioMed research international

authors： Kuciel-Lewandowska J,Gnus J,Pawlik-Sobecka L,Płaczkowska S,Kokot I,Kasperczak M,Paprocka-Borowicz M

更新日期：2018-01-02 00:00:00

abstract：:The application of chemotherapeutic drug adriamycin (ADR) in cancer therapy is limited by its side effects like high toxicity and insolubility. Nanomedicine offers new hope for overcoming the shortcomings. But how to increase in vivo stability and to control intracellular drug release is a key issue for nano-based for...

journal_title：BioMed research international

authors： Chen L,Chen F,Zhao M,Zhu X,Ke C,Yu J,Yan Z,Zhang F,Sun Y,Chen D,Jiang C,Zhao X,Gao Y,Guo S,Li W

更新日期：2015-01-01 00:00:00

abstract：:Approximately 40% of patients admitted to the medical intensive care unit (ICU) require mechanical ventilation. An accurate prediction of successful extubation in patients is a key clinical problem in ICU due to the fact that the successful extubation is highly associated with prolonged ICU stay. The prolonged ICU sta...

journal_title：BioMed research international

authors： Tu CS,Chang CH,Chang SC,Lee CS,Chang CT

更新日期：2018-01-04 00:00:00

abstract：:This paper describes a pilot study using a prototype telerehabilitation system (Ghostman). Ghostman is a visual augmentation system designed to allow a physical therapist and patient to inhabit each other's viewpoint in an augmented real-world environment. This allows the therapist to deliver instruction remotely and ...

journal_title：BioMed research international

authors： Chinthammit W,Merritt T,Pedersen S,Williams A,Visentin D,Rowe R,Furness T

更新日期：2014-01-01 00:00:00

abstract：Background:Fingertips are a common site for hand injuries. The ideal substitute for fingertip pulp is tissue that matches texturally with minimal donor site morbidity. We described anatomical findings from cadaveric studies and the reliability of the palmar ulnar artery perforator (PUAP) free flap techniques for the re...

journal_title：BioMed research international

authors： Pak CS,Jeon JI,Myung Y,Lee YK,Kim BJ,Jeong JH,Kim BK

更新日期：2018-05-09 00:00:00

abstract：:Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...

journal_title：BioMed research international

authors： Assi H,Sbaity E,Abdelsalam M,Shamseddine A

更新日期：2015-01-01 00:00:00

abstract：:Stem cells are biological cells that can self-renew and can differentiate into multiple cell lineages. Stem cell-based therapy is emerging as a promising alternative therapeutic option for various disorders. Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are isolated from various tissues and can b...

journal_title：BioMed research international

authors： Kang J,Fan W,Deng Q,He H,Huang F

更新日期：2019-01-29 00:00:00

abstract：:Anterior cruciate ligament injuries are common in humans, though cellular components of the knee have little regenerative or proliferation potential. This study investigated the differentiation of human amnion-derived mesenchymal stem cells (hAMSCs) into human anterior cruciate ligament fibroblasts (hACLFs) in vitro t...

journal_title：BioMed research international

authors： Li Y,Liu Z,Jin Y,Zhu X,Wang S,Yang J,Ren Y,Fu Q,Xiong H,Zou G,Liu Y

更新日期：2017-01-01 00:00:00

abstract：Introduction:Baseline neutrophil-to-lymphocyte ratio (NLR) has been repeatedly reported as a significant prognostic factor in advanced cancer patients. We explored whether changes in NLR may predict outcome of advanced cancer patients enrolled into phase 1 trials and treated with PD-1/PD-L1 inhibitors. Patients and Me...

journal_title：BioMed research international

authors： Moschetta M,Uccello M,Kasenda B,Mak G,McClelland A,Boussios S,Forster M,Arkenau HT

更新日期：2017-01-01 00:00:00

abstract：:Objective. To evaluate the association of -174G/C IL-6 polymorphism with failure in therapeutic response to methotrexate (MTX) or leflunomide (LEF). This prospective, observational cohort included 96 Mexican-Mestizo patients with moderate or severe rheumatoid arthritis (RA), initiating MTX or LEF, genotyped for IL-6 -...

journal_title：BioMed research international

authors： Ruiz-Padilla AJ,Gamez-Nava JI,Saldaña-Cruz AM,Murillo-Vazquez JD,Vazquez-Villegas ML,Zavaleta-Muñiz SA,Martín-Márquez BT,Ponce-Guarneros JM,Rodriguez Jimenez NA,Flores-Chavez A,Sandoval-Garcia F,Vasquez-Jimenez JC,Cardona-Muñoz E

更新日期：2016-01-01 00:00:00

abstract：:Red blood cell distribution width (RDW) is a parameter reported in complete blood cell count tests, and has been reported as an inflammatory biomarker. Multiple myeloma (MM) is known to be associated with inflammatory microenvironments. However, the importance of RDW has been seldom studied in MM. For this study, 146 ...

journal_title：BioMed research international

authors： Lee H,Kong SY,Sohn JY,Shim H,Youn HS,Lee S,Kim HJ,Eom HS

更新日期：2014-01-01 00:00:00

abstract：:Accurately annotating biological functions of proteins is one of the key tasks in the postgenome era. Many machine learning based methods have been applied to predict functional annotations of proteins, but this task is rarely solved by deep learning techniques. Deep learning techniques recently have been successfully...

journal_title：BioMed research international

authors： Zou X,Wang G,Yu G

更新日期：2017-01-01 00:00:00

abstract：Background:Liver ischaemia-reperfusion injury (IRI) remains a problem in liver transplantation. Interleukin-4 (IL-4) has been found to reduce liver IRI, but the exact mechanism remains unclear. Methods:Donor livers were infused with recombinant IL-4 or normal saline during cold storage, and the hepatocellular apoptosi...

journal_title：BioMed research international

authors： Deng M,Wang J,Wu H,Wang M,Cao D,Li J,Wu Y,Gong J

更新日期：2020-03-18 00:00:00