An Improved Binary Differential Evolution Algorithm to Infer Tumor Phylogenetic Trees.

Abstract:

:Tumourigenesis is a mutation accumulation process, which is likely to start with a mutated founder cell. The evolutionary nature of tumor development makes phylogenetic models suitable for inferring tumor evolution through genetic variation data. Copy number variation (CNV) is the major genetic marker of the genome with more genes, disease loci, and functional elements involved. Fluorescence in situ hybridization (FISH) accurately measures multiple gene copy number of hundreds of single cells. We propose an improved binary differential evolution algorithm, BDEP, to infer tumor phylogenetic tree based on FISH platform. The topology analysis of tumor progression tree shows that the pathway of tumor subcell expansion varies greatly during different stages of tumor formation. And the classification experiment shows that tree-based features are better than data-based features in distinguishing tumor. The constructed phylogenetic trees have great performance in characterizing tumor development process, which outperforms other similar algorithms.

journal_name

Biomed Res Int

authors

Liang Y,Liao B,Zhu W

doi

10.1155/2017/5482750

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

5482750

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

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