Abstract:
:Nowadays, several screening strategies are available to prevent cervical cancer, but inadequate resources, sociocultural barriers, and sampling issues impede their success in low-income countries. To overcome these issues, this study aimed to evaluate the performance of human papillomavirus (HPV) testing from dried urine spots (DUS). Eighty-eight urine samples (including 56 HPV DNA positive specimens) were spotted on filter paper, dried, and stored in paper-bags. HPV DNA was detected from the DUS after 1 week and 4 weeks of storage using a polymerase chain reaction (PCR) assay. The sensitivity, specificity, and concordance of the DUS-based HPV test were evaluated by comparing the results with those of HPV testing on fresh urine samples as the gold standard. The sensitivity of the test was 98.21% (95% CI: 90.56-99.68) for DUS stored for 1 week and 96.42% (95% CI: 87.88-99.01) for DUS stored for 4 weeks. The specificity was 100% (95% CI: 89.28-100) at both time points. The concordance between DUS and fresh urine HPV testing was "almost perfect" using the κ statistic. These preliminary data suggest that a DUS-based assay could bypass sociocultural barriers and sampling issues and therefore could be a suitable, effective tool for epidemiological surveillance and screening programs, especially in low-income countries.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Frati ER,Martinelli M,Fasoli E,Colzani D,Bianchi S,Binda S,Olivani P,Tanzi Edoi
10.1155/2015/283036subject
Has Abstractpub_date
2015-01-01 00:00:00pages
283036eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
临床试验,杂志文章abstract::Polyetheretherketone (PEEK), which has biomechanical performance similar to that of human cancellous bone, is used widely as a spinal implant material. However, its bioinertness and hydrophobic surface properties result in poor osseointegration. This study applies a novel modification method, arc ion plating (AIP), th...
journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7901562
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/867321
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/763715
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/523415
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2019-04-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/480498
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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更新日期:2018-11-21 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6038106
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