Abstract:
:Three novel low molecular weight polysaccharides (RLP-1a, RLP-2a, and RLP-3a) with 9004, 8761, and 7571 Da were first obtained by purifying the crude polysaccharides from the fruits of a traditional Chinese medicinal herb Rosae Laevigatae. The conditions for polysaccharides from the R. Laevigatae fruit (RLP) extraction were optimized by the response surface methodology, and the optimal conditions were as follows: extraction temperature, 93°C; extraction time, 2.8 h; water to raw material ratio, 22; extraction frequency, 3. Structural characterization showed that RLP-1a consisted of rhamnose, arabinose, xylose, glucose, and galactose with the ratio of 3.14 : 8.21 : 1 : 1.37 : 4.90, whereas RLP-2a was composed of rhamnose, mannose, glucose, and galactose with the ratio of 1.70 : 1 : 93.59 : 2.73, and RLP-3a was composed of rhamnose, arabinose, xylose, mannose, glucose, and galactose with the ratio of 6.04 : 26.51 : 2.05 : 1 : 3.17 : 31.77. The NMR analyses revealed that RLP-1a, RLP-2a, and RLP-3a contained 6, 4, and 6 types of glycosidic linkages, respectively. RLP-1a and RLP-3a exhibited distinct antioxidant abilities on the superoxide anions, 1,1-diphenyl-2-picrylhydrazyl (DPPH), and hydroxyl radicals in vitro. RLPs could decrease the serum lipid levels, elevate the serum high-density lipoprotein cholesterol levels, enhance the antioxidant enzymes levels, and upregulate of FADS2, ACOX3, and SCD-1 which involved in the lipid metabolic processes and oxidative stress in the high-fat diet-induced rats. These results suggested that RLPs ameliorated the high-fat diet- (HFD-) induced lipid metabolism disturbance in the rat liver through the peroxisome proliferator-activated receptor (PPAR) signaling pathway. Low molecular weight polysaccharides of RLP could be served as a novel potential functional food for improving hyperlipidemia and liver oxidative stress responses.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Zhang X,Hu Y,Jin C,Wu Wdoi
10.1155/2020/2043785subject
Has Abstractpub_date
2020-10-22 00:00:00pages
2043785eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::Photosystem II photochemistry and phycobiliprotein (PBP) genes of red algae Kappaphycus alvarezii, raw material of κ -carrageenan used in food and pharmaceutical industries, were analyzed in this study. Minimum saturating irradiance (I k) of this algal species was less than 115 μmol m(-2) s(-1). Its actual PSII effici...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/256549
更新日期:2013-01-01 00:00:00
abstract::Mixed-phase TiO2 nanocomposite thin films consisting of anatase and rutile prepared on commercially pure Ti sheets via the electrochemical anodization and annealing treatments were investigated in terms of their photocatalytic activity for antibacterial use around dental implants. The resulting films were characterize...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/705871
更新日期:2015-01-01 00:00:00
abstract::Mind-body practices (MBP) are known to induce electrophysiological and morphological changes, whereas reports related to changes of neurotrophins are surprisingly scarce. Consequently, in the current paper, we focused on the Quadrato motor training (QMT), a newly developed whole-body movement-based MBP, which has been...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/275062
更新日期:2015-01-01 00:00:00
abstract::Plantar fasciitis is a cause of chronic pain under the heel and bottom of the foot. One of the treatments to reduce pain consists of using plantar orthoses to address specific imbalances during foot placement or gait. The aim of the present study was to determine if reduction of pain with a treatment based on plantar ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/3594150
更新日期:2018-12-12 00:00:00
abstract:Objective:To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their relevant factors, as well as the relationship between child growth and propranolol. Methods:A total of 506 patients with confirmed or suspected IHs were enrolled, and a total of 439 cases ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/2728952
更新日期:2019-11-25 00:00:00
abstract::Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/845032
更新日期:2013-01-01 00:00:00
abstract::The aims of this study were to evaluate the contribution of chromosomal microarray analysis (CMA) in the prenatal diagnosis of fetuses with central nervous system (CNS) anomalies but normal chromosomal karyotype. A total of 46 fetuses with CNS anomalies with or without other ultrasound anomalies but normal karyotypes ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/426379
更新日期:2015-01-01 00:00:00
abstract::DNA-binding proteins often play important role in various processes within the cell. Over the last decade, a wide range of classification algorithms and feature extraction techniques have been used to solve this problem. In this paper, we propose a novel DNA-binding protein prediction method called HMMBinder. HMMBinde...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4590609
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:CD57 is normally found on NK-cells, but little is known about its expression in prostatic tissue. METHODS:We investigated CD57 expression by immunohistochemistry using tissue microarrays containing 3262 prostate cancers (PCa), lymph node metastases, and benign prostatic tissue. The results were compared wit...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/356427
更新日期:2014-01-01 00:00:00
abstract::Angiogenesis plays a decisive role in the growth and spread of cancer and angiopoietin-2 (Ang2) is in the spotlight of studies for its unique role in modulating angiogenesis. The aim of this study was to introduce a computational simulation approach to screen aptamers with high binding ability for Ang2. We carried out...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/658712
更新日期:2015-01-01 00:00:00
abstract::In our study, we evaluated the feasibility of a new sampling method for splenic stiffness (SS) measurement by Quantitative Acoustic Radiation Force Impulse Elastography (Virtual Touch Tissue Quantification (VTTQ)).We measured SS in 54 patients with HCV-related cirrhosis of whom 28 with esophageal varices (EV), 27 with...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/365982
更新日期:2014-01-01 00:00:00
abstract::Music exposure is known to play a positive role in learning and memory and can be a complementary treatment for anxiety and fear. However, whether juvenile music exposure affects adult behavior is not known. Two-week-old Sprague-Dawley rats were exposed to music for 2 hours daily or to background noise (controls) for ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8740674
更新日期:2019-07-14 00:00:00
abstract::MicroRNAs (miRs) are small noncoding RNA molecules and recently have demonstrated that altered expression and functions are their tight association with ulcerative colitis (UC). Previous microarray study reported that miR-214 was downregulated in the sigmoid colon of patients with active UC, but the roles of miR-214 i...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8524972
更新日期:2017-01-01 00:00:00
abstract::This study was aimed to evaluate the in vitro lethal activity of the nematophagous fungi Clonostachys rosea against 5 nematodes species belonging to different taxa. Two groups of 35 Petri dishes (PD) each were divided into 5 series of 7 (PD). Group 1 (series 1, 2, 3, 4, and 5) contained only water agar; meanwhile grou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3501827
更新日期:2018-03-20 00:00:00
abstract::Introduction. The triangular fibrocartilage complex (TFCC) provides both mobility and stability of the radiocarpal joint. TFCC lesions are difficult to diagnose due to the complex anatomy. The standard treatment for TFCC lesions is arthroscopy, posing surgery-related risks onto the patients. This feasibility study aim...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5870875
更新日期:2017-01-01 00:00:00
abstract::To explore the antitumor effect of hypoxia-inducible factor-1α short hairpin RNA (HIF-1α shRNA) delivered by ultrasound targeted microbubble destruction (UTMD) and transcatheter arterial embolization (TAE) on rats with hepatic cancer. After the models of transplantation hepatoma were established, Wistar rats were rand...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/1937460
更新日期:2019-02-19 00:00:00
abstract::We aimed to predict the ten-year cardiovascular disease (CVD) risk among low-income urban dwellers of metropolitan Malaysia. Participants were selected from a cross-sectional survey conducted in Kuala Lumpur. To assess the 10-year CVD risk, we employed the Framingham risk scoring (FRS) models. Significant determinants...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/516984
更新日期:2015-01-01 00:00:00
abstract::Modified poly(aspartic acid)/poly(vinyl alcohol) interpenetrating polymer network (KPAsp/PVA IPN) hydrogel for drug controlled release was synthesized by a simple one-step method in aqueous system using poly(aspartic acid) grafting 3-aminopropyltriethoxysilane (KH-550) and poly(vinyl alcohol) (PVA) as materials. The h...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/236745
更新日期:2015-01-01 00:00:00
abstract::The aging process causes a number of changes in the skin, including oxidative stress and dyschromia. The kojic acid (KA) is iron chelator employed in treatment of skin aging, and inhibits tyrosinase, promotes depigmentation. Nanotechnology-based drug delivery systems, such as liquid crystalline systems (LCSs), can mod...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/271276
更新日期:2013-01-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder caused by selective loss of dopaminergic neurons in the substantia nigra pars compacta which leads to dysfunction of cerebral pathways critical for the control of movements. The diagnosis of PD is based on motor symptoms, such as bradykinesia, akinesia, muscular...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/519816
更新日期:2014-01-01 00:00:00
abstract::It has been reported that many modifications occur with the increase of oxidative stress during storage in erythrocytes. In order to delay these negative changes, we evaluated whether the addition of substances likely to protect antioxidant capacity in stored blood would be useful. Therefore, we investigated the effec...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3057384
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Although binge drinking prevalence and correlates among young people have been extensively studied in the USA and Northern Europe, less is known for Southern Europe countries with relatively healthier drinking cultures. OBJECTIVE:We aimed at analyzing prevalence and correlates of binge drinking in a represe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/930795
更新日期:2014-01-01 00:00:00
abstract::Nutrient overload leads to impaired muscle oxidative capacity and insulin sensitivity. However, comparative analyses of the effects of dietary manipulation on skeletal muscles with different fiber composition are lacking. This study aimed to investigate the selective adaptations in the soleus and tibialis anterior mus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/569623
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND AND AIM:Trace elements and vitamins play a vital role in human body to perform its function properly. Thalassemic patients are at risk of micronutrient deficiency. This study estimated levels of vitamins A, C, E, B12, folic acid, total homocysteine (tHcy), and methylmalonic acid (MMA) along with trace elemen...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/261761
更新日期:2014-01-01 00:00:00
abstract:Background:Overuse of antibiotics is a major driver for rapid spread of antimicrobial resistance worldwide, particularly common in China. The close linkage between hospital revenue and sales of drugs has become the key incentive for overprescription of antibiotics. Since 2009, the Chinese government implemented a serie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9262170
更新日期:2020-10-22 00:00:00
abstract::Blood pressure is the most important, modifiable risk factor for cardiovascular diseases. Lifestyle factors and also workload are the main, potential risk factors for the development of hypertension. This study focused on the early detection of unknown hypertension by screening employees in the hotel and restaurant in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6820160
更新日期:2018-04-08 00:00:00
abstract::Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts. It is necessary to construct a uniform fra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7457131
更新日期:2017-01-01 00:00:00
abstract::Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8798546
更新日期:2017-01-01 00:00:00
abstract:Methods:circRNA expression was analysed in six cerebrospinal fluid (CSF) samples from three patients of the infectious and noninfectious phases using an Arraystar Human circRNA Array. Differentially altered circRNAs were validated by quantitative real-time polymerase chain reaction (qRT-PCR) in the 66 CSF samples of 33...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2536272
更新日期:2020-05-02 00:00:00
abstract:Background:The purpose of this study was to evaluate the association between the non-high-density lipoprotein cholesterol (non-HDL-C) to high-density lipoprotein cholesterol (HDL-C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non-HDL-C/HDL-C in the prognosis of CAD. Meth...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/7146028
更新日期:2020-03-07 00:00:00