Abstract:
BACKGROUND:The presence of common risk factors suggests that there is a relationship between osteoporosis and cardiovascular disease, possibly via dyslipidemia and inflammation. We investigated the relationships among the lipid profile, the inflammation marker high-sensitivity C-reactive protein (hsCRP), bone turnover markers, and bone mineral density (BMD) to assess the correlation between osteoporosis and cardiovascular disease and identify factors predicting osteoporosis. METHODS:The study included 759 Korean women older than 20 years of age. The BMD, serum lipid profile, and levels of hsCRP, cross-linked C-terminal peptide (CTX), and osteocalcin were measured. We compared the serum biomarkers between groups with normal and low BMD and assessed the correlations between the levels of bone turnover markers and the lipid profile and hsCRP level. RESULTS:The concentrations of CTX, osteocalcin, and total cholesterol were significantly higher in the low BMD group than in the normal BMD group in premenopausal women group. However, hsCRP was not correlated with these parameters. Multivariate logistic regression analysis revealed that TC (OR, 1.647; 95% CI, 1.190-2.279) and osteocalcin (OR, 1.044; 95% CI, 1.002-1.088) had an increased risk of low BMD in premenopausal women. CONCLUSIONS:These results indicate that total cholesterol concentration is correlated with the levels of bone turnover markers, suggesting that it might predict osteoporosis in premenopausal women.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Jeong TD,Lee W,Choi SE,Kim JS,Kim HK,Bae SJ,Chun S,Min WKdoi
10.1155/2014/398397subject
Has Abstractpub_date
2014-01-01 00:00:00pages
398397eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/9368483
更新日期:2016-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2020/4671349.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2020/7638969
更新日期:2020-06-30 00:00:00
abstract:Background:The present study aims to investigate the incidence and risk factors associated with postoperative delirium in patients undergoing spine surgery. Methods:PubMed, EMBASE, Cochrane Library, and Science Citation Index were searched up to August 2019 for studies examining postoperative delirium following spine ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/2139834
更新日期:2019-11-26 00:00:00
abstract::Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediter...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/839019
更新日期:2014-01-01 00:00:00
abstract::Mung bean is a hepatoprotective agent in dietary supplements. Fermentation and germination processes are well recognized to enhance the nutritional values especially the concentration of active compounds such as amino acids and GABA of various foods. In this study, antioxidant and hepatoprotective effects of freeze-dr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/693613
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to analyse the circadian behavioural responses of mice carrying a functional knockout of the Per3 gene (Per3(-/-)) to different light : dark (L : D) cycles. Male adult wild-type (WT) and Per3(-/-) mice were kept under 12-hour light : 12-hour dark conditions (12L : 12D) and then transferred to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/170795
更新日期:2014-01-01 00:00:00
abstract::Technetium-99 conjugated with methylene diphosphonate (99Tc-MDP) is an effective anti-inflammatory drug in treating rheumatoid arthritis (RA) for over 15 years in China. However, as a special form of bisphosphonate, the antiosteoporotic effect of 99Tc-MDP is unclear. We systematically investigated the effects of 99Tc-...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/7902760
更新日期:2018-10-14 00:00:00
abstract::This study investigates the mechanism underlying the improving effect of zinc on fertility in obese rats using proteomics. The effects of three different doses of ZnSO4 on spermatogenesis and hormone levels were studied. Testicular spermatogenesis was observed by HE staining. Serum estrogen and testosterone levels wer...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9876363
更新日期:2020-05-04 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDA) is the fourth most common cancer causing death in the United States. Early tumor recurrence is an important contributor to the dismal prognosis. The availability of an accurate prognostic biomarker for predicting disease recurrence following curative resection will be beneficial ...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2014/468959
更新日期:2014-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the synovial membrane that results in the destruction of bone and cartilage in affected joints. Tocilizumab is a biological agent and an anti-interleukin-6 (IL-6) receptor monoclonal antibody that blocks IL-6-mediated inflammatory processes in RA patients...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/607137
更新日期:2013-01-01 00:00:00
abstract::This study evaluated the microtensile bond strength (μTBS) of 1-step self-etch adhesives (1-SEAs) and 2-step self-etch adhesives (2-SEAs) to pulp chamber dentin immediately after bleaching with 2 types of common bleaching techniques. Pulp chamber dentin of bovine teeth was bleached using 30% hydrogen peroxide (H2O2) s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1313586
更新日期:2016-01-01 00:00:00
abstract::Background and Purposes. The 320-detector row CT scanner enables visualization of whole-brain hemodynamic information (dynamic CT angiography (CTA) derived from CT perfusion scans). However, arterial image quality in dynamic CTA (dCTA) is inferior to arterial image quality in standard CTA. This study evaluates whether...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/603173
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION AND OBJECTIVES:An elevated neutrophil-to-lymphocyte ratio (NLR) has been suggested to be associated with a poor prognosis in several cancers. We evaluated the utility of an elevated NLR as a biomarker to predict the prognosis of metastatic castration-resistant prostate cancer (mCRPC) patients treated with ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7538647
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Wear-related failures and instabilities are frequent failure mechanisms of total knee replacements. High-conforming designs may provide additional stability for the joint. This study analyzes the effects of a ligamentous insufficiency on the stability and the wear behavior of a high-conforming knee design. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/821475
更新日期:2014-01-01 00:00:00
abstract::The objective of this study was to investigate the iontophoretic delivery of lidocaine hydrochloride through porcine skin and to compare the effects of modulated alternating and direct current iontophoresis. Continuous and modulated iontophoresis was applied for one hour and two hours (0-1 h and 4-5th h) using a 1% w/...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/537941
更新日期:2014-01-01 00:00:00
abstract::Lung cancer is one of the most malignant tumors in the world. Early diagnosis and treatment of lung cancer are vitally important to reduce the mortality of lung cancer patients. In the present study, we attempt to identify the candidate biomarkers for lung cancer by weighted gene co-expression network analysis (WGCNA)...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3416807
更新日期:2020-06-10 00:00:00
abstract::Copy number variants (CNVs) as detected by chromosomal microarray analysis (CMA) significantly contribute to the etiology of neurodevelopmental disorders, such as developmental delay (DD), intellectual disability (ID), and autism spectrum disorder (ASD). This study summarizes the results of 3.5 years of CMA testing by...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3284534
更新日期:2016-01-01 00:00:00
abstract::Cardiotonic drugs mainly include digitalis, catecholamines, phosphodiesterase inhibitors, and calcium sensitizers, which have been successively discovered and applied in clinical practice. However, there are only a few new drugs available in this field, and the selection is very limited. Digitalis, catecholamines, and...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9731467
更新日期:2019-09-19 00:00:00
abstract:CONTEXT:The 7th (2009) edition of the AJCC melanoma staging system incorporates tumor (Breslow) thickness, MR, and ulceration in stratifying T1 primary melanomas. Compared to the prior 6th (2001) edition, MR has replaced CL for thin melanomas. OBJECTIVE:We sought to identify and report differences of the classificatio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/898719
更新日期:2013-01-01 00:00:00
abstract:Background:Inconsistent data have been reported for the effectiveness of intramuscular botulinum toxin type A (BTXA) in patients with limb spasticity after stroke. This meta-analysis of available randomized controlled trials (RCTs) aimed to determine the efficacy and safety of BTXA in adult patients with upper and lowe...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2019/8329306
更新日期:2019-04-07 00:00:00
abstract::Circulating cell-free DNA has been recognized as an accurate marker for the diagnosis of prostate cancer, whereas the role of urine cell-free DNA (UCF DNA) has never been evaluated in this setting. It is known that normal apoptotic cells produce highly fragmented DNA while cancer cells release longer DNA. We thus veri...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/270457
更新日期:2013-01-01 00:00:00
abstract::The polarization of macrophages and its anti-inflammatory and proinflammatory properties play a significant role in host response after implant placement to determine the outcome of osseointegration and long-term survival. In the previous study, we immobilized an antimicrobial peptide, GL13K, onto titanium surfaces to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2327034
更新日期:2020-07-24 00:00:00
abstract::It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/283429
更新日期:2013-01-01 00:00:00
abstract::Traumatic brain injury (TBI) leads to important and deleterious neuroinflammation, as evidenced by indicators such as edema, cytokine production, induction of nitric oxide synthase, and leukocyte infiltration. After TBI, cerebral vascular endothelial cells play a crucial role in the pathogenesis of inflammation. In ou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/910260
更新日期:2014-01-01 00:00:00
abstract::Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/920902
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:Fusarium, Aspergillus, and Dematiaceous are the most common fungal species causing keratitis in tropical countries. Herein we report a prospective study on fungal keratitis caused by these three fungal species. METHODOLOGY:A prospective investigation was undertaken to evaluate eyes with presumed fungal keratit...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/605308
更新日期:2013-01-01 00:00:00
abstract::Surgical flaps are frequently affected by ischemia/reperfusion (I/R) injury. Calcium-sensing receptor (CaSR) and stromal cell-derived factor-1α (SDF-1α) are closely associated with myocardial I/R injury. This study was performed to evaluate the feasibility of applying SDF-1α to counteract CaSR activation-mediated I/R ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8945850
更新日期:2018-01-11 00:00:00
abstract::Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/941764
更新日期:2013-01-01 00:00:00
abstract::Light traps represent the most used attractive system to collect and monitor phlebotomine sand flies. Recent studies have suggested that light traps can be easily upgraded by the use of light-emitting diode (LED) with positive effects on trap design, weight, and battery life. However, scant data on the effect of diffe...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6432637
更新日期:2018-06-27 00:00:00
abstract::Ceramic materials show excellent esthetic behavior, along with an absence of hypersensitivity, making them a possible alternative implant material in dental surgery. However, their surface properties enable only limited osseointegration compared to titanium implants. Within this study, a novel surface coating techniqu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/742180
更新日期:2014-01-01 00:00:00