Abstract:
:Rheumatoid arthritis (RA) is a chronic inflammatory disorder of the synovial membrane that results in the destruction of bone and cartilage in affected joints. Tocilizumab is a biological agent and an anti-interleukin-6 (IL-6) receptor monoclonal antibody that blocks IL-6-mediated inflammatory processes in RA patients. In order to identify novel disease-related proteins and candidate biomarkers, we analyzed the changes in the serum proteome profiles of patients with RA who were treated with tocilizumab. Serum samples were collected from the RA patients before and after tocilizumab treatment. Following immunodepletion of major proteins, the proteins were digested and labeled with isobaric tag, iTRAQ reagent. The proteins were identified and quantified using liquid chromatography-tandem mass spectrometry. Among a total of 311 proteins identified, seven were decreased and 16 were increased by tocilizumab treatment. Although some of the proteins are known to be related to RA, several are currently unknown with respect to their relationship to RA and may be involved in the development of this disease. This study is the first to perform a comparative serum proteomic analysis of RA patients treated with tocilizumab. Our results may contribute to the identification of novel disease-related proteins and enhance the understanding of the pathogenesis of RA.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yanagida M,Kawasaki M,Fujishiro M,Miura M,Ikeda K,Nozawa K,Kaneko H,Morimoto S,Takasaki Y,Ogawa H,Takamori K,Sekigawa Idoi
10.1155/2013/607137subject
Has Abstractpub_date
2013-01-01 00:00:00pages
607137eissn
2314-6133issn
2314-6141journal_volume
2013pub_type
杂志文章abstract::Lung cancer is a leading cause of death worldwide. Currently, in differential diagnosis of lung cancer, accurate classification of cancer types (adenocarcinoma, squamous cell carcinoma, and small cell carcinoma) is required. However, improving the accuracy and stability of diagnosis is challenging. In this study, we d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/4067832
更新日期:2017-01-01 00:00:00
abstract::We demonstrate the potential of differentiating embryonic and induced pluripotent stem cells by the regularized linear and decision tree machine learning classification algorithms, based on a number of intragene methylation measures. The resulting average accuracy of classification has been proven to be above 95%, whi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/976362
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/687826
更新日期:2014-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2015/948131
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3165379
更新日期:2018-12-23 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2015/857327
更新日期:2015-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/434257
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/327470
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1648419
更新日期:2020-01-11 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/906819
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/8430637
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812923
更新日期:2020-12-22 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/415651
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4192745
更新日期:2020-02-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/687541
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6368958
更新日期:2019-11-07 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/623254
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/424652
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8568459
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/438403
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/849571
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2854186
更新日期:2020-09-23 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/680615
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/3105248
更新日期:2020-02-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6274545
更新日期:2019-04-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/690529
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/437328
更新日期:2015-01-01 00:00:00