Boosting Secondary Metabolite Production and Discovery through the Engineering of Novel Microbial Biosensors.

abstract：:Cancer cells acquire unique secretome compositions that contribute to tumor development and metastasis. The aim of our study was to elucidate the biological processes involved in cervical cancer, by performing a proteomic analysis of the secretome from the following informative cervical cell lines: SiHa (HPV16+), HeLa...

journal_title：BioMed research international

authors： Kontostathi G,Zoidakis J,Makridakis M,Lygirou V,Mermelekas G,Papadopoulos T,Vougas K,Vlamis-Gardikas A,Drakakis P,Loutradis D,Vlahou A,Anagnou NP,Pappa KI

更新日期：2017-01-01 00:00:00

abstract：:The objective of this study is to introduce a method using a percutaneous full-endoscopic interlaminar approach via a surrounding nerve root discectomy (SNRD) operative route that involves removing the protrusive disc via both the shoulder and the axilla of the corresponding nerve root for the treatment of ventral-typ...

journal_title：BioMed research international

authors： Shi C,Kong W,Liao W,Lu Y,Fu Y,Wen H,Du Q,Wu F

更新日期：2018-02-12 00:00:00

abstract：:Aldosterone synthase (CYP11B2) is a key enzyme for the biosynthesis of aldosterone, which plays a significant role for the regulation of blood pressure. Excess aldosterone can cause the dysregulation of the renin-angiotensin-aldosterone system (RAAS) and lead to hypertension. Therefore, research and development of CYP...

journal_title：BioMed research international

authors： Luo G,Lu F,Qiao L,Chen X,Li G,Zhang Y

更新日期：2016-01-01 00:00:00

abstract：:Contrast enhanced magnetic resonance imaging (CE-MRI) has acquired a central role in the field of diagnosis and evaluation of breast cancer due to its high sensitivity; on the other hand, MRI has shown a variable specificity because of the wide overlap between the imaging features of benign and malignant lesions. Ther...

journal_title：BioMed research international

authors： Mazzei MA,Di Giacomo L,Fausto A,Gentili F,Mazzei FG,Volterrani L

更新日期：2018-10-21 00:00:00

abstract：Background:The reliability of blood pressure (BP) measurement in hospitalized patients is a topic of debate and the therapeutic implication of the routinely collected BP profiles is probably overestimated. When measurements are performed in elderly patients, further potential sources of misinterpretation occur. Method...

journal_title：BioMed research international

authors： Del Giorno R,Heiniger PS,Balestra L,Gabutti L

更新日期：2019-04-01 00:00:00

abstract：:This study included 30 patients with diagnosed rheumatoid arthritis (RA) and 30 test subjects without RA (control group). The objective of the study was to examine both groups for the presence of temporomandibular disorders (TMD) and morphological changes of the temporomandibular joint (TMJ). All individuals were exam...

journal_title：BioMed research international

authors： Witulski S,Vogl TJ,Rehart S,Ottl P

更新日期：2014-01-01 00:00:00

abstract：:Gold nanoparticles (AuNPs) have several potential biological applications as well as excellent biocompatibility. AuNPs with surface modification using polyethylene glycol (PEG-AuNPs) can facilitate easy conjugation with various biological molecules of interest. To examine the anticancer bioactivity of PEG-AuNPs, we in...

journal_title：BioMed research international

authors： Huang YC,Yang YC,Yang KC,Shieh HR,Wang TY,Hwu Y,Chen YJ

更新日期：2014-01-01 00:00:00

abstract：:Coronal decompensation is a common complication in Lenke 1 or 2 AIS patients after selective thoracic fusion (STF). However, the majority who developed immediately postoperative coronal decompensation experienced improvement and the related factors are not fully understood. The aim of this retrospective study was to i...

journal_title：BioMed research international

authors： Jiang H,Shao W,Xu E,Ji Z,Lin T,Meng Y,Ma J,Wang C,Gao R,Zhou X

更新日期：2018-12-09 00:00:00

abstract：:The aim of this study was to determine the capacity of biofilm formation of atypical enteropathogenic Escherichia coli (aEPEC) strains on abiotic and biotic surfaces. Ninety-one aEPEC strains, isolated from feces of children with diarrhea, were analyzed by the crystal violet (CV) assay on an abiotic surface after 24 h...

journal_title：BioMed research international

authors： Culler HF,Mota CM,Abe CM,Elias WP,Sircili MP,Franzolin MR

更新日期：2014-01-01 00:00:00

abstract：Purpose:The aim of this study is to evaluate the effectiveness of laboratory serum tests in the diagnosis of infected nonunion. Methods:Forty-two patients suspected of having infected nonunion were investigated in the study. The serum levels of white blood-cell count (WBC), C-reactive protein (CRP), erythrocyte sedime...

journal_title：BioMed research international

authors： Wang S,Yin P,Quan C,Khan K,Wang G,Wang L,Cui L,Zhang L,Zhang L,Tang P

更新日期：2017-01-01 00:00:00

abstract：Objective:To analyse the short-term adverse effects (AEs) of propranolol in the treatment of infantile hemangiomas (IHs) and their relevant factors, as well as the relationship between child growth and propranolol. Methods:A total of 506 patients with confirmed or suspected IHs were enrolled, and a total of 439 cases ...

journal_title：BioMed research international

authors： Li X,Yang K,Li H,Huo R

更新日期：2019-11-25 00:00:00

abstract：:Magnetic resonance imaging (MRI) based on the ferritin heavy chain 1 (FTH1) reporter gene has been used to trace stem cells. However, whether FTH1 expression is affected by stem cell differentiation or whether cell differentiation is affected by reporter gene expression remains unclear. Here, we explore the relationsh...

journal_title：BioMed research international

authors： Mu T,Qin Y,Liu B,He X,Liao Y,Sun J,Qiu J,Li X,Zhong Y,Cai J

更新日期：2018-06-26 00:00:00

abstract：:A prospective nonrandomized controlled study was conducted to explore the association between ocular dominance and degree of myopia in patients with anisometropia and to investigate the character of visual evoked potential (VEP) in high anisometropias. 1771 young myopia cases including 790 anisometropias were recruite...

journal_title：BioMed research international

authors： Wang Q,Wu Y,Liu W,Gao L

更新日期：2016-01-01 00:00:00

abstract：Background:The aim of this study was to examine whether oral propranolol has any effect on neurodevelopment outcomes in young children with problematic infantile hemangiomas (IHs). Methods:Thirty-six children with a diagnosis of problematic IH who were treated with oral propranolol were compared with 34 healthy childr...

journal_title：BioMed research international

authors： Wang C,Wang Q,Xiang B,Chen S,Xiong F,Ji Y

更新日期：2018-02-25 00:00:00

abstract：:Studies pertaining to trans fatty acids (TFA), which have been implicated in development of chronic diseases, are more relevant in developing countries where nutrition transition is changing traditional habits and practices. Measuring TFA is an arduous task because of the need for fat biopsies. This study identifies a...

journal_title：BioMed research international

authors： Abraham RA,Bahl VK,Parshad R,Seenu V,Roy A,Golandaz S,Dorairaj P,Ramakrishnan L

更新日期：2013-01-01 00:00:00

abstract：:In vivo confocal microscopy (IVCM) of the living human cornea offers the ability to perform repeated imaging without tissue damage. Studies using corneal IVCM have led to significant contributions to scientific and clinical knowledge of the living cornea in health and pathological states. Recently the application of c...

journal_title：BioMed research international

authors： Wang EF,Misra SL,Patel DV

更新日期：2015-01-01 00:00:00

abstract：:In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in prostate homeostasis. Most of the studies evaluated intraprostatic hormone metabolism using cell lines or preprocessed specimens. Using an ex vivo model of intact tissue cultures with preserved architecture, we characteriz...

journal_title：BioMed research international

authors： Gianfrilli D,Pierotti S,Pofi R,Leonardo C,Ciccariello M,Barbagallo F

更新日期：2014-01-01 00:00:00

abstract：:Chronic Obstructive Pulmonary Disease (COPD) is defined as a disease characterized by persistent, progressive airflow limitation. Recent studies have underlined that COPD is correlated to many systemic manifestations, probably due to an underlying pattern of systemic inflammation. In COPD fractional exhaled Nitric Oxi...

journal_title：BioMed research international

authors： Malerba M,Radaeli A,Olivini A,Damiani G,Ragnoli B,Montuschi P,Ricciardolo FL

更新日期：2014-01-01 00:00:00

abstract：:Mycobacterium bovis causes classic bovine tuberculosis, a zoonosis which is still a concern in Africa. Biofilm forming ability of two Mycobacterium bovis strains was assessed on coupons of cement, ceramic, or stainless steel in three different microbiological media at 37°C with agitation for 2, 3, or 4 weeks to determ...

journal_title：BioMed research international

authors： Adetunji VO,Kehinde AO,Bolatito OK,Chen J

更新日期：2014-01-01 00:00:00

abstract：:Purpose. To compare the results of extracorporeal shock wave therapy (ESWT) for insertional Achilles tendinopathy (IAT) with or without Haglund's deformity. Methods. Between September 2014 and May 2015, all patients who underwent ESWT were retrospectively enrolled in this study. A total of 67 patients were available f...

journal_title：BioMed research international

authors： Wu Z,Yao W,Chen S,Li Y

更新日期：2016-01-01 00:00:00

abstract：:We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achi...

journal_title：BioMed research international

authors： Janić M,Lunder M,Šabovič M

更新日期：2015-01-01 00:00:00

abstract：:Tomatoes and tomato based-foods contain beneficial microorganisms and various organic acids that have important nutritional values for human. The objective of this study was to access the physiochemical properties of fermented tomatoes juices and to evaluate the competitiveness of lactic acid bacteria (LAB) against Li...

journal_title：BioMed research international

authors： Bah A,Albano H,Barbosa JB,Fhoula I,Gharbi Y,Najjari A,Boudabous A,Teixeira P,Ouzari HI

更新日期：2019-02-26 00:00:00

abstract：:Diverse high energy diets have been utilized to precipitate obesity and related metabolic disorders in rodent models, though the dietary intervention has not absolutely been standardized. The present study established usage of a customized semipurified normal control diet (NCD) and high fat diet (HFD), for research st...

journal_title：BioMed research international

authors： Sasidharan SR,Joseph JA,Anandakumar S,Venkatesan V,Ariyattu Madhavan CN,Agarwal A

更新日期：2013-01-01 00:00:00

abstract：:Autophagic elements typically appear as spherical bodies. During their life they undergo a series of changes (e.g., fusion, degradation of content, and swelling) which influence their size in a way that may be characteristic for cell type, stage of maturation, or various experimentally manipulated parameters. A simple...

journal_title：BioMed research international

authors： Kovács AL

更新日期：2014-01-01 00:00:00

abstract：:The aim of the present study was to analyze the relationship between the sum of the four limbs' pulse pressure (Sum-PP) and brachial-ankle pulse wave velocity (baPWV) and atherosclerosis risk factors and evaluate the feasibility of Sum-PP in diagnosing atherosclerosis systemically. For the purpose, a cross-sectional s...

journal_title：BioMed research international

authors： Zheng Y,Li Z,Shu H,Liu M,Chen Z,Huang J

更新日期：2015-01-01 00:00:00

abstract：:Several lines of evidence indicate that amyloid β (Aβ), particularly Aβ oligomers (AβOs), plays a causative role in Alzheimer's disease. However, the mechanisms underlying the action of an anti-AβO antibody to clarify the toxic action of AβOs remain elusive. Here, we showed that the anti-AβO antibody (monoclonal 72D9)...

journal_title：BioMed research international

authors： Matsubara E,Takamura A,Okamoto Y,Oono H,Nakata T,Wakasaya Y,Kawarabayashi T,Shoji M

更新日期：2013-01-01 00:00:00

abstract：Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...

journal_title：BioMed research international

authors： Luo Q,Zhang X

更新日期：2020-07-31 00:00:00

abstract：:Hosts' innate defense systems are upregulated by antimicrobial peptide elicitors (APEs). Our aim was to investigate the effects of hyperthermia, ultraviolet A rays (UVA), and ultraviolet C rays (UVC) as well as glucose and ascorbic acid (AA) on the regulation of human β-defensin 1 (DEFB1), cathelicidin (CAMP), and int...

journal_title：BioMed research international

authors： Cruz Díaz LA,Flores Miramontes MG,Chávez Hurtado P,Allen K,Gonzalez Ávila M,Prado Montes de Oca E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Varicocele is associated with high levels of DNA damage in spermatozoa due to oxidative stress and elevated levels of sperm DNA fragmentation, which has been currently proposed to be an essential additional diagnostic test to be recommended for patients with clinical varicocele. The aim of this study was to ...

journal_title：BioMed research international

authors： Kadioglu TC,Aliyev E,Celtik M

更新日期：2014-01-01 00:00:00

abstract：:Alterations in muscle protein turnover of the unaffected side of stroke patients could contribute to physical disability. We investigated whether hypercatabolic activity occurred in unaffected arm muscle and whether supplemented essential amino acids (EAAs) could limit muscle hypercatabolism (MH). Thirty-eight dysphag...

journal_title：BioMed research international

authors： Aquilani R,Boselli M,D'Antona G,Baiardi P,Boschi F,Viglio S,Iadarola P,Pasini E,Barbieri A,Dossena M,Bongiorno AI,Verri M

更新日期：2014-01-01 00:00:00