Abstract:
BACKGROUND:We performed a retrospective study to assess whether the initial molecular characteristics of glioblastomas (GBMs) were associated with the response to the bevacizumab/irinotecan chemotherapy regimen given at recurrence. RESULTS:Comparison of the genomic and gene expression profiles of the responders (n = 12) and nonresponders (n = 13) demonstrated only slight differences and could not identify any robust biomarkers associated with the response. In contrast, a significant association was observed between GBMs molecular subtypes and response rates. GBMs assigned to molecular subtype IGS-18 and to classical subtype had a lower response rate than those assigned to other subtypes. In an independent series of 33 patients, neither EGFR amplification nor CDKN2A deletion (which are frequent in IGS-18 and classical GBMs) was significantly associated with the response rate, suggesting that these two alterations are unlikely to explain the lower response rate of these GBMs molecular subtypes. CONCLUSION:Despite its limited sample size, the present study suggests that comparing the initial molecular profiles of responders and nonresponders might not be an effective strategy to identify biomarkers of the response to bevacizumab given at recurrence. Yet it suggests that the response rate might differ among GBMs molecular subtypes.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Laffaire J,Di Stefano AL,Chinot O,Idbaih A,Gallego Perez-Larraya J,Marie Y,Vintonenko N,Boisselier B,Farina P,Delattre JY,Figarella-Branger D,Honnorat J,Sanson M,Ducray Fdoi
10.1155/2014/282815subject
Has Abstractpub_date
2014-01-01 00:00:00pages
282815eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
临床试验,杂志文章,多中心研究abstract:PURPOSE:To determine the predictive factors that affect short term and long term postoperative drift in intermittent exotropia after bilateral lateral rectus recession and to evaluate its effect on surgical outcome. METHODS:Retrospective review of 203 patients with diagnosis of intermittent exotropia, who had surgical...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/482093
更新日期:2014-01-01 00:00:00
abstract::The proper functioning of a hospital computer system is an arduous work for managers and staff. However, inconsistent policies are frequent and can produce enormous problems, such as stolen information, frequent failures, and loss of the entire or part of the hospital data. This paper presents a new method named EMRlo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/542016
更新日期:2015-01-01 00:00:00
abstract::Autophagic elements typically appear as spherical bodies. During their life they undergo a series of changes (e.g., fusion, degradation of content, and swelling) which influence their size in a way that may be characteristic for cell type, stage of maturation, or various experimentally manipulated parameters. A simple...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/578698
更新日期:2014-01-01 00:00:00
abstract:OBJECT:The aim of this report was to explore the clinical presentation, radiological features, treatment methods, and outcome of micro-AVMs presenting with intracerebral hemorrhage. METHODS:The clinical data, radiological features, treatment, and follow-up results for a consecutive series of 13 cases with micro-AVMs w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/257153
更新日期:2015-01-01 00:00:00
abstract::Metabolic bone disorder is usually caused by abnormalities of minerals and hormones metabolism. Recently, it has been proved by several studies that the renin-angiotensin system (RAS) in local bone tissue is directly involved in bone metabolism. Activation of skeletal RAS plays an important role in bone metabolic diso...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/932691
更新日期:2013-01-01 00:00:00
abstract::The valorization of Crocus sativus L. by-products has become important given its interesting content of bioactive molecules. In the present study, aqueous tepal extract (ATE) studied eggplant seedling's growth and physiology under a plastic tunnel. ATE was foliage sprayed 3 times every 15 days, with various concentrat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8812157
更新日期:2020-11-05 00:00:00
abstract:Purpose:Ischemic ocular disorders may be treated by hypervolemic hemodilution. The presumed therapeutic benefit is based on a volume effect and improved rheological factors. The aim was to investigate the acute effect of intravenous hydroxyethyl starch on retrobulbar hemodynamics in patients with nonarteritic anterior ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/4756313
更新日期:2018-02-06 00:00:00
abstract::IL-1 family includes IL-38 (IL-1F10) and the subfamily of IL-36 and is the central mediators of inflammatory diseases, including pustular psoriasis, atopic dermatitis, rheumatoid arthritis, and gut inflammation. The purpose of the study was to evaluate on tissue of the patients with inflammatory bowel disease (IBD), t...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/5140691
更新日期:2018-12-10 00:00:00
abstract::To explore the mechanisms by which andrographolide inhibits gastric cancer cell proliferation and metastasis, we employed the gastric cell line SGC7901 to investigate the anticancer effects of andrographolide. The cell survival ratio, cell migration and invasion, cell cycle, apoptosis, and matrix metalloproteinase act...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6242103
更新日期:2017-01-01 00:00:00
abstract::With the recent advancement in the field of ocular therapy, drug delivery approaches have been elevated to a new concept in terms of nonionic surfactant vesicles (NSVs), that is, the ability to deliver the therapeutic agent to a patient in a staggered profile. However the major drawbacks of the conventional drug deliv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/263604
更新日期:2014-01-01 00:00:00
abstract::Cisplatin is an antitumor drug used in the treatment of a wide variety of malignancies. However, its primary dose-limiting side effect is kidney injury, which is a major clinical concern. To help understand mechanisms involved in the development of kidney injury, cisplatin rodent model has been developed. Given the co...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/1462802
更新日期:2018-09-12 00:00:00
abstract::Flash-lamp pulsed-dye laser (FPDL) is a nonablative technology, typically used in vascular malformation therapy due to its specificity for hemoglobin. FPDL treatments were performed in a large group of patients with persistent and/or recalcitrant different dermatological lesions with cutaneous microvessel involvement....
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/7981640
更新日期:2016-01-01 00:00:00
abstract::The research was performed on male Wistar rats based on assumptions that new microelement preparations containing metal nanoparticles and their agglomerates had potential. Morphological and functional changes in tissues in the injection site and dynamics of chemical element metabolism (25 indicators) in body were asse...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243173
更新日期:2015-01-01 00:00:00
abstract:Background:Statins are commonly used in the secondary prevention of coronary artery disease. Studies have shown that the rate of statin use is low among patients with coronary artery disease. In this study, we aimed to investigate the reasons for poor patient compliance with statin treatment. Methods:A total of 504 pa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8961690
更新日期:2018-06-07 00:00:00
abstract::A surface plasmon resonance- (SPR-) based recognition method applying H-2 Ld:Ig/peptides complexes for ex vivo monitoring cellular immune responses during murine infection with Leishmania (Leishmania) amazonensis is described. Lymphocytes from lesion-draining popliteal lymph nodes were captured on a carboxylated senso...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9089748
更新日期:2017-01-01 00:00:00
abstract:UNLABELLED:The safety and efficacy of endoscopic sphincterotomy with large balloon dilation (EPLBD) are unclear. This study compares the safety and efficacy between EPLBD and endoscopic sphincterotomy (EST). PATIENTS AND METHODS:Literatures were searched for randomized controlled trials in PUBMED, EMBASE, and Cochrane...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/673103
更新日期:2015-01-01 00:00:00
abstract::Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/845032
更新日期:2013-01-01 00:00:00
abstract::High-grade gliomas are the main cause of death in children with brain tumours. Despite recent advances in cancer therapy, their prognosis remains poor and the treatment is still challenging. To date, surgery followed by radiotherapy and temozolomide is the standard therapy. However, increasing knowledge of glioma biol...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/215135
更新日期:2015-01-01 00:00:00
abstract::L-amino acid oxidases are enzymes found in several organisms, including venoms of snakes, where they contribute to the toxicity of ophidian envenomation. Their toxicity is primarily due to enzymatic activity, but other mechanisms have been proposed recently which require further investigation. L-amino acid oxidases ex...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/196754
更新日期:2014-01-01 00:00:00
abstract::Glucagon-like peptide-1 (GLP-1) is glucose-dependent insulinotropic hormone secreted from enteroendocrine L cells. Its long-acting analogue, exendin-4, is equipotent to GLP-1 and is used to treat type 2 diabetes mellitus. In addition, exendin-4 has effects on the central and peripheral nervous system. In this study, w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/315848
更新日期:2013-01-01 00:00:00
abstract::The normal physiological loads from muscles experienced by the spine are largely unknown due to a lack of data. The aim of this study is to investigate the effects of varying muscle directions on the outcomes predicted from finite element models of human lumbar spine. A nonlinear finite element model of L3-L5 was empl...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4517471
更新日期:2018-01-03 00:00:00
abstract::Acetabular fractures involving predominantly the anterior column associated with a disruption of the quadrilateral surface can be treated with instrumentation implementing the stabilization of the quadrilateral surface. The recently introduced suprapectineal quadrilateral buttress plate is specifically designed to pre...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8231301
更新日期:2017-01-01 00:00:00
abstract::Introduction. Infection and apoptosis are combined triggers for inflammation in dental tissues. Octamer-binding transcription factor 4-B1 (OCT4B1), a novel spliced variant of OCT4 family, could respond to the cellular stress and possess antiapoptotic property. However, its specific role in dental pulpitis remains unkn...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2756891
更新日期:2017-01-01 00:00:00
abstract:Methods:The implantation sites, fetus resorption, and abnormal fetuses were studied in pregnant mice treated with different doses of BaP by oral gavage from day 1 to day 10 of gestation. Additionally, apoptosis and related signaling pathway, and the migration and invasion of trophoblasts, were assessed before and after...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8983494
更新日期:2020-10-16 00:00:00
abstract::Sophora davidii (Franch.) Kom. ex Pavol is an important medicinal plant and a feeding scrub with ecological value. The effects of different gamma irradiation doses (20-140 Kr) on seed germination and seedling morphology were investigated in S. davidii, and intersimple sequence repeat (ISSR) markers were used to identi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/8576404
更新日期:2017-01-01 00:00:00
abstract:INTRODUCTION:While studies using various materials to overcome ischemia-reperfusion (IR) injury are becoming increasingly common, studies on the effects of botulinum toxin A (BoTA) on IR injury in musculocutaneous flaps are still limited. The purpose of this study was to examine our hypotheses that BoTA provide protect...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/1074178
更新日期:2017-01-01 00:00:00
abstract::It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/283429
更新日期:2013-01-01 00:00:00
abstract::Abdominal pregnancy is a very rare form of ectopic pregnancy, associated with high morbidity and mortality for both fetus and mother. It is, and often, seen in poor resource nations, where early diagnosis is often a major challenge due to poor prenatal care and lack of medical resources. An advanced abdominal pregnanc...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/102479
更新日期:2014-01-01 00:00:00
abstract::Background. There has been a decline in emphasis of the value of physical examination in heart failure (HF) with increased reliance on cardiac imaging. We aim to study the clinical and prognostic significance of positive hepatojugular reflux (HJR) on discharge in patients hospitalized with HF. Methods. Using the ESCAP...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5734749
更新日期:2017-01-01 00:00:00
abstract::Small intestinal bacterial overgrowth (SIBO) is associated with chronic gastrointestinal diseases and structural/functional abnormalities of the gastrointestinal tract. SIBO's association with clinical characteristics is unclear. This study investigates the association between clinical factors and SIBO according to la...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/1064029
更新日期:2016-01-01 00:00:00