Abstract:
INTRODUCTION:Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. MATERIALS AND METHODS:To confirm the association, a total of 91 subjects who received primary total hip arthroplasty using lateral approach performed by one skilled orthopedic surgeon were studied. All the patients were consecutively enrolled at the Center of Diagnosis and Treatment for Joint Diseases, Drum Tower Hospital affiliated to the Medical School of Nanjing University from 2010 to 2012. All the subjects received venography 3-5 days after operation. We measured P-selectin by means of a highly sensitive sandwich ELISA technique and a commercially available test reagent set. RESULTS:No significant association was detected between P-selectin and DVT (all P values > 0.05). ΔsP-selectin was correlated with weight, APTT after operation, history of DVT, and diagnosis of primary disease ( P values were 0.03, 0.03, 0.04, and 0.02, resp.). CONCLUSION:P-selectin may not be a predicted factor for deep vein thrombosis after total hip arthroplasty.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Shi D,Xu X,Xu Z,Nakamura T,Pang Y,Yao C,Wang F,Chen D,Dai J,Jiang Qdoi
10.1155/2014/783967subject
Has Abstractpub_date
2014-01-01 00:00:00pages
783967eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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