A Naphthalenic Derivative ND-1 Inhibits Thrombus Formation by Interfering the Binding of Fibrinogen to Integrin αIIbβ3.

abstract：:It is well known that Down syndrome (DS) is a condition in which extra genetic material causes delays in the way a child develops, both mentally and physically. Intellectual disability is the foremost and most debilitating trait, which caused loss of cognitive abilities and the development of early onset Alzheimer's d...

journal_title：BioMed research international

authors： Yu B,Zhang B,Zhou WB,Wang QW,Yuan P,Yang YQ,Kong J

更新日期：2015-01-01 00:00:00

abstract：:Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...

journal_title：BioMed research international

authors： Kim JL,Kim YH,Kang MK,Gong JH,Han SJ,Kang YH

更新日期：2013-01-01 00:00:00

abstract：:Background and Aims. CIN is a major and serious complication following PCI in patients with ACS. It is unclear whether a higher serum ferritin level is associated with an increased risk of CIN in high-risk patients. Thus, we conducted this study to assess the predictive value of SF for the risk of CIN after PCI. Metho...

journal_title：BioMed research international

authors： Zhu B,Hou J,Gong Y,Yan G,Wang Q,Wang D,Qiao Y,Chen Y,Tang C

更新日期：2016-01-01 00:00:00

abstract：:Ablative therapies have been utilized with increasing frequency for the treatment of Barrett's esophagus with and without dysplasia. Multiple modalities are available for topical ablation of the esophagus, but radiofrequency ablation (RFA) remains the most commonly used. There have been significant advances in techniq...

journal_title：BioMed research international

authors： Tuttle R,Nurkin SJ,Hochwald SN

更新日期：2014-01-01 00:00:00

abstract：Background:A deficiency in steroid 5α-reductase type 2 is an autosomal recessive disorder. Affected individuals manifested ambiguous genitalia, which is caused by decreased dihydrotestosterone (DHT) synthesis in the fetus. Methods:We analyzed 25 patients with 5α-reductase deficiency in China. Seventeen of the 25 patie...

journal_title：BioMed research international

authors： Han B,Cheng T,Zhu H,Yu J,Zhu WJ,Song HD,Yao H,Qiao J

更新日期：2020-06-09 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide. Adenocarcinoma, the most commonly diagnosed histologic type of lung cancer, is associated with smoking. Cigarette smoke promotes inflammation on the airways, which might be mediated by Th17 cells. This inflammatory environment may contribute to tumor developm...

journal_title：BioMed research international

authors： Islas-Vazquez L,Prado-Garcia H,Aguilar-Cazares D,Meneses-Flores M,Galicia-Velasco M,Romero-Garcia S,Camacho-Mendoza C,Lopez-Gonzalez JS

更新日期：2015-01-01 00:00:00

abstract：:Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO...

journal_title：BioMed research international

authors： Wang L,Ma J,Guo C,Chen C,Yin Z,Zhang X,Chen X

更新日期：2016-01-01 00:00:00

abstract：:High mobility group box 1 (HMGB1) is an ubiquitous protein that plays different roles in the nucleus, cytoplasm, and extracellular space. It is an important DAMP molecule that allows communication between damaged or tumor cells and the immune system. Tumor cells exploit HMGB1's ability to activate intracellular pathwa...

journal_title：BioMed research international

authors： Mardente S,Mari E,Massimi I,Fico F,Faggioni A,Pulcinelli F,Antonaci A,Zicari A

更新日期：2015-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...

journal_title：BioMed research international

authors： Vianna VF,Bonfim DC,Cavalcanti Ados S,Fernandes MC,Kahn SA,Casado PL,Lima IC,Murray SS,Murray EJ,Duarte ME

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To evaluate the changes of keratocytes and dendritic cells in the central clear graft by laser scanning in vivo confocal microscopy after penetrating keratoplasty (PK). METHODS:Thirty adult subjects receiving PK at Shandong Eye Institute and with clear grafts and no sign of immune rejection after surgery were ...

journal_title：BioMed research international

authors： Wang D,Song P,Wang S,Sun D,Wang Y,Zhang Y,Gao H

更新日期：2016-01-01 00:00:00

abstract：:Fatty acids (C6-C18) found in human amniotic fluid, colostrum, and maternal milk reduce behavioral indicators of experimental anxiety in adult Wistar rats. Unknown, however, is whether the anxiolytic-like effects of fatty acids provide a natural mechanism against anxiety in young offspring. The present study assessed ...

journal_title：BioMed research international

authors： Bernal-Morales B,Cueto-Escobedo J,Guillén-Ruiz G,Rodríguez-Landa JF,Contreras CM

更新日期：2017-01-01 00:00:00

abstract：:Dental modeling resins have been developed for use in areas where highly precise resin structures are needed. The manufacturers claim that these polymethyl methacrylate/methyl methacrylate (PMMA/MMA) resins show little or no shrinkage after polymerization. This study examined the polymerization shrinkage of five denta...

journal_title：BioMed research international

authors： Kwon TY,Ha JY,Chun JN,Son JS,Kim KH

更新日期：2014-01-01 00:00:00

abstract：:The spectrum of kidney disease-associated monoclonal immunoglobulin and plasma cell malignancies is remarkably broad and encompasses nearly all nephropathologic entities. Multiple myeloma with kidney impairment at presentation is a medical emergency since the recovery of kidney function is associated with survival ben...

journal_title：BioMed research international

authors： Mussap M,Merlini G

更新日期：2014-01-01 00:00:00

abstract：Background:Low birth weight is the leading cause of infant and child mortality and contributes to several poor health outcomes. Proper knowledge of risk factors of low birth weight is important for identifying those mothers at risk and thereby for planning and taking appropriate actions. This study investigates factors...

journal_title：BioMed research international

authors： Hailu LD,Kebede DL

更新日期：2018-04-23 00:00:00

abstract：Objective:To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method:We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults...

journal_title：BioMed research international

authors： Li J,Zhu W,Gao X,Li X

更新日期：2020-03-03 00:00:00

abstract：:During a spaceflight, astronauts need to live in a spacecraft on orbit for a long time, and the relationship between humans and microorganisms in the closed environment of space is not the same as on the ground. The dynamic study of microorganisms in confined space shows that with the extension of the isolation time, ...

journal_title：BioMed research international

authors： Chen Y,Wu B,Zhang C,Fan Z,Chen Y,Xin B,Xie Q

更新日期：2020-06-20 00:00:00

abstract：Background:It is unclear whether computer navigation can improve the accuracy and reliability of targeted lower limb alignment correction following open-wedge high tibial osteotomy (HTO). This meta-analysis was designed to compare the accuracy and reliability of limb alignment correction between computer navigated and ...

journal_title：BioMed research international

authors： Han SB,Kim HJ,Lee DH

更新日期：2017-01-01 00:00:00

abstract：:The sphingosine-1-phosphate (S1P) system regulates both thymic and lymph nodes T cell egress which is essential for producing and maintaining the recycling T cell repertoire. Infection with the protozoan parasite Trypanosoma cruzi induces a hormonal systemic deregulation that has impact in the thymic S1P homeostasis t...

journal_title：BioMed research international

authors： Flávia Nardy A,Santos L,Freire-de-Lima CG,Morrot A

更新日期：2015-01-01 00:00:00

abstract：:Objectives. To construct a frailty index from next-of-kin information of the last year of life of community-dwelling 50 years old or older adults and test its association with health services utilization. Methods. Cross-sectional analysis from next-of-kin data available from the last wave of the Mexican Health and Agi...

journal_title：BioMed research international

authors： Pérez-Zepeda MU,Cesari M,Carrillo-Vega MF,Salinas-Escudero G,Tella-Vega P,García-Peña C

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Promoting participation in sport organizations may be a population strategy for preventing falls in older people. In this study, we examined whether participation in sport organizations is associated with fewer falls in older people even after adjusting for multiple individual and environmental factors. METH...

journal_title：BioMed research international

authors： Hayashi T,Kondo K,Suzuki K,Yamada M,Matsumoto D

更新日期：2014-01-01 00:00:00

abstract：:Long-term chronic intermittent exposure to altitude hypoxia is a labor phenomenon requiring further research. Using a rat model, we examined whether this type of exposure differed from chronic exposure in terms of pulmonary artery remodeling and other features. Rats were subjected to chronic hypoxia (CH, n = 9) and lo...

journal_title：BioMed research international

authors： Brito J,Siques P,Arribas SM,López de Pablo AL,González MC,Naveas N,Arriaza K,Flores K,León-Velarde F,Pulido R,Ordenes S,López MR

更新日期：2015-01-01 00:00:00

abstract：:Recently, an important topic of the acquired immunodeficiency syndrome (AIDS) had been published in 2013. In this report, the expression of the IFN-induced myxovirus resistance 2 (MX2) had been defined the function to kill the human immunodeficiency virus (HIV). The screening from the Traditional Chinese Medicine (TCM...

journal_title：BioMed research international

authors： Hung TC,Lee WY,Chen KB,Chan YC,Chen CY

更新日期：2014-01-01 00:00:00

abstract：:Exposure to dioxins, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is reported to affect the autoimmune system and increase the risk of autoimmune disease. Generally, dioxin exerts its toxicity via aryl hydrocarbon receptor (AhR). Primary biliary cholangitis (PBC) is a chronic autoimmune disease, and its pathoge...

journal_title：BioMed research international

authors： She C,Wang J,Tang N,Liu Z,Xu L,Liu B

更新日期：2020-08-24 00:00:00

abstract：:[This retracts the article DOI: 10.1155/2014/479180.]. ...

journal_title：BioMed research international

authors： BioMed Research International

更新日期：2016-01-01 00:00:00

abstract：:The explosive growth of high-throughput experimental methods and resulting data yields both opportunity and challenge for selecting the correct drug to treat both a specific patient and their individual disease. Ideally, it would be useful and efficient if computational approaches could be applied to help achieve opti...

journal_title：BioMed research international

authors： Cui H,Zhang M,Yang Q,Li X,Liebman M,Yu Y,Xie L

更新日期：2018-03-25 00:00:00

abstract：:Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties....

journal_title：BioMed research international

authors： Landová H,Vetchý D,Gajdziok J,Doležel P,Muselík J,Dvořáčková K,Jekl V,Hauptman K,Knotek Z

更新日期：2014-01-01 00:00:00

abstract：:Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (...

journal_title：BioMed research international

authors： Nagai T,Kanasaki M,Srivastava SP,Nakamura Y,Ishigaki Y,Kitada M,Shi S,Kanasaki K,Koya D

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to detect the inhibitory action of the early growth response gene-1 DNA enzyme (EDRz) as a carrying agent by liposomes on vascular smooth muscle cell proliferation and intimal hyperplasia. An autogenous vein graft model was established. EDRz was transfected to the graft vein. The vein graft s...

journal_title：BioMed research international

authors： Liu C,Zhang X,Wang S,Cheng M,Liu C,Wang S,Hu X,Zhang Q

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:This study mainly aimed to explore the association between brain-derived neurotropic factor (BDNF) Val66Met polymorphism and posttraumatic stress disorder (PTSD) among flood survivors in China. METHODS:Individuals who experienced the 1998 Dongting Lake flood in Southeast Huarong, China, were enrolled in this...

journal_title：BioMed research international

authors： Dai W,Kaminga AC,Wu X,Wen SW,Tan H,Yan J,Deng J,Lai Z,Liu A

更新日期：2017-01-01 00:00:00

abstract：Objective:The underlying mechanisms by which cystatin C affects cardiovascular disease (CVD) are not very clear. Metabolic syndrome (MetS) is a cluster of risk factors that increase the risk of CVD. Here, we aimed to investigate the association of cystatin C with metabolic syndrome and cardiovascular outcomes in non-ST...

journal_title：BioMed research international

authors： Mao Q,Zhao N,Wang Y,Li Y,Xiang C,Li L,Zheng W,Xu S,Zhao XH

更新日期：2019-06-16 00:00:00