An electromechanical left ventricular wedge model to study the effects of deformation on repolarization during heart failure.

Abstract:

:Heart failure is a major and costly problem in public health, which, in certain cases, may lead to death. The failing heart undergo a series of electrical and structural changes that provide the underlying basis for disturbances like arrhythmias. Computer models of coupled electrical and mechanical activities of the heart can be used to advance our understanding of the complex feedback mechanisms involved. In this context, there is a lack of studies that consider heart failure remodeling using strongly coupled electromechanics. We present a strongly coupled electromechanical model to study the effects of deformation on a human left ventricle wedge considering normal and hypertrophic heart failure conditions. We demonstrate through a series of simulations that when a strongly coupled electromechanical model is used, deformation results in the thickening of the ventricular wall that in turn increases transmural dispersion of repolarization. These effects were analyzed in both normal and failing heart conditions. We also present transmural electrograms obtained from these simulations. Our results suggest that the waveform of electrograms, particularly the T-wave, is influenced by cardiac contraction on both normal and pathological conditions.

journal_name

Biomed Res Int

authors

Rocha BM,Toledo EM,Barra LP,dos Santos RW

doi

10.1155/2015/465014

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

465014

eissn

2314-6133

issn

2314-6141

journal_volume

2015

pub_type

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