Abstract:
:Targeted drug delivery using folate receptors is one of the most interesting chemotherapeutic research areas over the past few years. A novel folate targeted copolymer was synthesized using dextran stearate coupled to folic acid. FT-IR and NMR spectroscopy were used to confirm successful conjugation. Micelles prepared using this copolymer were characterized for their particle size, zeta potential, critical micelle concentration (CMC), drug loading capacity, and release efficiency. Cytotoxicity and cellular uptake of the micelles were estimated using CT-26 colorectal carcinoma cell line. FT-IR and NMR spectroscopy confirmed production of folate grafted dextran stearate copolymer. Low CMC value indicates that the copolymers are suitable for preparation of stable micelles useful in parenteral dosage forms. Particle size and zeta potential of the targeted nanoparticles were 105.5 ± 2.0 nm and -21.2 mV, respectively. IC50 of etoposide loaded in folate grafted dextran stearate enhanced about 20-fold compared to the pure drug (0.49 ± 0.11 μg/mL versus 9.41 ± 0.52 μg/mL). It seems that etoposide loaded in micelles of folate grafted dextran stearate copolymer is promising in reducing drug resistance of colorectal cancer by boosting etoposide cellular uptake.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Varshosaz J,Hassanzadeh F,Sadeghi-Aliabadi H,Firozian Fdoi
10.1155/2014/708593subject
Has Abstractpub_date
2014-01-01 00:00:00pages
708593eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章abstract::Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life. Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/539805
更新日期:2015-01-01 00:00:00
abstract::The etiology of nephrotic syndrome is complex and ranges from primary glomerulonephritis to secondary forms. Patients with nephrotic syndrome often need immunosuppressive treatment with its side effects and may progress to end stage renal disease. This review focuses on recent advances in the treatment of primary caus...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7689254
更新日期:2017-01-01 00:00:00
abstract::Smoldering multiple myeloma (SMM) is an asymptomatic precursor stage of multiple myeloma (MM) characterized by clonal bone marrow plasma cells (BMPC) ≥ 10% and/or M protein level ≥ 30 g/L in the absence of end organ damage. It represents an intermediate stage between monoclonal gammopathy of undetermined significance ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/623254
更新日期:2015-01-01 00:00:00
abstract::Mesenchymal stem cells (MSCs) are defined as pluripotent cells found in numerous human tissues, including bone marrow and adipose tissue. Such MSCs, isolated from bone marrow and adipose tissue, have been shown to differentiate into bone and cartilage, along with other types of tissues. Therefore, MSCs represent a pro...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/436029
更新日期:2014-01-01 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Introduction. Pelvic organ prolapse (POP) and urinary incontinence (UI) have increasing prevalence in the elderly population. The aim of this study was to compare the comorbidities of these procedures between <70 y/o and ≥70 y/o patients. Materials and Methods. In our retrospective study over a period of 2.5 years, 40...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/5184595
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/9858923
更新日期:2017-01-01 00:00:00
abstract:Purpose:To study the effect of duodenal-jejunal omega switch (DJOS) in combination with different dietary patterns on the retinol-binding protein (RBP4), fetuin-A, and fibroblast growth factor 21 (FGF21) plasma levels and their hepatic gene expressions in rats. Methods:A high-fat diet (HF) was given to 28 rats and 28 ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3472190
更新日期:2018-08-16 00:00:00
abstract::The Purkinje network is a specialized conduction system within the heart that ensures the proper activation of the ventricles to produce effective contraction. Its role during ventricular arrhythmias is less clear, but some experimental studies have suggested that the Purkinje network may significantly affect the gene...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/621034
更新日期:2015-01-01 00:00:00
abstract:Background and Aims:The value of hepatocyte regeneration in predicting the outcomes of hepatitis B-related acute-on-chronic liver failure (HBV-ACLF) is not fully assessed. The present study was aimed at establishing a novel scoring system to predict patients' outcomes within 3 months by applying serological indicators ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5062873
更新日期:2020-08-06 00:00:00
abstract::SARS-CoV-2 pandemic and COVID-19 diffusion have recently become an international public health emergency. Cancer patients, as a frail population, are particularly exposed to the risk related to infections. The clinical decision-making process and the organizational workflow of radiotherapy department should be revised...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4892382
更新日期:2020-05-26 00:00:00
abstract::The aim of this study was to examine whether dexmedetomidine improves acute liver injury in a rat model. Twenty-eight male Wistar albino rats weighing 300-350 g were allocated randomly to four groups. In group 1, normal saline (NS) was injected into the lungs and rats were allowed to breathe spontaneously. In group 2,...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/621827
更新日期:2014-01-01 00:00:00
abstract:Objective:Cognitive impairment is considered to be an important complication of spinal cord injury (SCI), but its underlying mechanism remains unclear. The purpose of this study is to explore whether serum CCL21 can be used as a potential biomarker of cognitive impairment in SCI. Methods:In Neck-Shoulder and Lumbocrur...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6692802
更新日期:2020-12-09 00:00:00
abstract:Introduction:To identify and analyze factors that influence administration, recognition, and compliance of medicine among community residents in Jilin Province, China. Methods:A survey was carried out among 2417 community residents in Jilin Province, China, to study their administration (CRA), recognition (CRR), and c...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8730212
更新日期:2020-07-18 00:00:00
abstract::The aim of the present study was to analyze the relationship between the sum of the four limbs' pulse pressure (Sum-PP) and brachial-ankle pulse wave velocity (baPWV) and atherosclerosis risk factors and evaluate the feasibility of Sum-PP in diagnosing atherosclerosis systemically. For the purpose, a cross-sectional s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/434516
更新日期:2015-01-01 00:00:00
abstract::Methadone remains the most common form of pharmacological therapy for opioid dependence; however, there is a lack of explanation for the reports of its relatively low success rate in achieving complete abstinence. One hypothesis is that in vivo binding of methadone to the plasma glycoprotein alpha-1-acid glycoprotein ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/108902
更新日期:2013-01-01 00:00:00
abstract::Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/920902
更新日期:2014-01-01 00:00:00
abstract::The nonnucleoside reverse transcriptase inhibitors, used for the treatment of HIV infections, are reported to have low bioavailability pertaining to high first-pass metabolism, high protein binding, and enzymatic metabolism. They also show low permeability across blood brain barrier. The CNS is reported to be the most...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5984014
更新日期:2017-01-01 00:00:00
abstract::Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the key...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/827635
更新日期:2014-01-01 00:00:00
abstract::In the present study, we explored SA's activity against DOX-induced cardiotoxicity and revealed its underlying mechanisms. Male Wistar rats (weight, 190-210g; n = 6) were randomly divided into four groups: group I, normal control; group II, DOX 15 mg/kg via intraperitoneal (ip) route; group III, administered DOX+SA 20...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3921796
更新日期:2020-03-10 00:00:00
abstract::Renal inflammation can result in renal injury. Uric acid (UA) is the final product of purine metabolism in humans and because of the lack of urate oxidase, UA may accumulate in tissues, including kidney, causing inflammation. Galangin was isolated from a traditional Chinese medicine plant and possesses several benefic...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3018357
更新日期:2019-05-26 00:00:00
abstract::It has been described renal damage in rats with vascular calcification. The organic anion transporter 5 (Oat5) is only expressed in kidney, and its urinary excretion was proposed as potential early biomarker of renal injury. The aim of this study was to evaluate the Oat5 renal expression and its urinary excretion in a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/283429
更新日期:2013-01-01 00:00:00
abstract::Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2719460
更新日期:2016-01-01 00:00:00
abstract::A series of sulfonamide-bearing azaheterocyclic Schiff base derivatives 3(a-j) were synthesized as carbonic anhydrase inhibitors. The substituted benzene sulfonyl chlorides 1(a-d) were reacted with N2H4 to get aromatic sulfonyl hydrazides 2(a-d). The intermediate hydrazides 2(a-d) were treated with substituted aldehyd...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8104107
更新日期:2020-02-20 00:00:00
abstract:AIMS/INTRODUCTION:Determining the prevalence of diabetes and its cardiovascular complications and all-cause mortality in older chronic complex patients. MATERIALS AND METHODS:We carried out a multicenter retrospective study and included a randomized sample of 932 CCP people. We assessed the prevalence of diabetes acco...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/6078498
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Anaemia with an estimated prevalence of 35-75% among pregnant women is a major cause of maternal deaths in Nigeria. objective: To determine the prevalence of anaemia, associated sociodemographic factors and red cell morphological pattern among pregnant women during booking at the University Teaching Hospital...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/849080
更新日期:2014-01-01 00:00:00
abstract:Background:Statins are commonly used in the secondary prevention of coronary artery disease. Studies have shown that the rate of statin use is low among patients with coronary artery disease. In this study, we aimed to investigate the reasons for poor patient compliance with statin treatment. Methods:A total of 504 pa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8961690
更新日期:2018-06-07 00:00:00
abstract:Background:The chromobox (CBX) proteins CBX2, CBX4, CBX6, CBX7, and CBX8, also known as Polycomb (Pc) proteins, are canonical components of the Polycomb repressive complex 1 (PRC1). Abundant evidence indicates that abnormal expression of Pc proteins is associated with a variety of tumors, but their role in the pathogen...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1155/2019/6436825
更新日期:2019-05-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4193541
更新日期:2020-11-17 00:00:00
abstract::Transient receptor potential polycystic 2 (TRPP2) exerts vital roles in various types of cancer; however, its underlying mechanisms remain largely unknown. This study is aimed at investigating whether knockdown of TRPP2 affected the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling pathway and...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4375075
更新日期:2020-11-14 00:00:00