Abstract:
:Lung cancer is one of the leading triggers for cancer death worldwide. In this study, the relationship of the aberrantly methylated and differentially expressed genes in lung adenocarcinoma (LUAD) with cancer prognosis was investigated, and 5 feature genes were identified eventually. Specifically, we firstly downloaded the LUAD-related mRNA expression profile (including 57 normal tissue samples and 464 LUAD tissue samples) and Methy450 expression data (including 32 normal tissue samples and 373 LUAD tissue samples) from the TCGA database. The package "limma" was used to screen differentially expressed genes and aberrantly methylated genes, which were intersected for identifying the hypermethylated downregulated genes (DGs Hyper) and the hypomethylated upregulated genes (UGs Hypo). GO annotation and KEGG pathway enrichment analysis were further performed, and it was found that these DGs Hyper and UGs Hypo were predominantly activated in the biological processes and signaling pathways such as the regulation of vasculature development, DNA-binding transcription activator activity, and Ras signaling pathway, indicating that these genes play a vital role in the initiation and progression of LUAD. Additionally, univariate and multivariate Cox regression analyses were conducted to find the genes significantly associated with LUAD prognosis. Five genes including SLC2A1, TNS4, GAPDH, ATP8A2, and CASZ1 were identified, with the former three highly expressed and the latter two poorly expressed in LUAD, indicating poor prognosis of LUAD patients as judged by survival analysis.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Wang X,Shi D,Zhao D,Hu Ddoi
10.1155/2020/1807089subject
Has Abstractpub_date
2020-09-25 00:00:00pages
1807089eissn
2314-6133issn
2314-6141journal_volume
2020pub_type
杂志文章abstract::This study aimed to compare within-subject blood pressure (BP) variabilities from different measurement techniques. Cuff pressures from three repeated BP measurements were obtained from 30 normotensive and 30 hypertensive subjects. Automatic BPs were determined from the pulses with normalised peak amplitude larger tha...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5201069
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/241780
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3024793
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/7538604
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/630803
更新日期:2013-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5756189
更新日期:2019-01-06 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6135696
更新日期:2020-01-09 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4560647
更新日期:2018-05-15 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2803790
更新日期:2017-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/1375085
更新日期:2018-12-18 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/657414
更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2568301
更新日期:2016-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/2868564
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3762179
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6832867
更新日期:2019-05-21 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/935719
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/906356
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2019/2150159
更新日期:2019-07-01 00:00:00
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/348659
更新日期:2014-01-01 00:00:00