Possible Effect of Concomitant Prokinetics and Herbal Medicines against Nausea in Patients Taking Lubiprostone.

Abstract:

Background and Aim:Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods:We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. Results:The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (p = 0.007). Conclusions:Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.

journal_name

Biomed Res Int

authors

Yamamoto T,Osumi S,Yanagisawa D,Yamato H,Aoyagi H,Isono A,Abe K,Kita H

doi

10.1155/2017/3762179

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

3762179

eissn

2314-6133

issn

2314-6141

journal_volume

2017

pub_type

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