Abstract:
Background and Aim:Lubiprostone is a novel laxative that sometimes causes nausea, but preventive strategies remain unconfirmed. Methods:We retrospectively chose 126 patients prescribed lubiprostone from 2013 to 2016. Medical records were reviewed to clarify whether nausea developed after administration of the drug. Background characteristics, including concomitant medicines, were also reviewed. Results:The most common adverse symptom was diarrhea (23.8%). Nausea occurred in 16 patients (12.7%). Patients taking either prokinetics or herbal medicines or both were unlikely to develop nausea (p = 0.007). Conclusions:Concomitant prokinetics and/or herbal medicines may help alleviate lubiprostone-induced nausea.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Yamamoto T,Osumi S,Yanagisawa D,Yamato H,Aoyagi H,Isono A,Abe K,Kita Hdoi
10.1155/2017/3762179subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3762179eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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