Development of In Vitro-In Vivo Correlation/Relationship Modeling Approaches for Immediate Release Formulations Using Compartmental Dynamic Dissolution Data from "Golem": A Novel Apparatus.

abstract：:Human diseases are abnormal medical conditions in which multiple biological components are complicatedly involved. Nevertheless, most contributions of research have been made with a single type of genetic data such as Single Nucleotide Polymorphism (SNP) or Copy Number Variation (CNV). Furthermore, epigenetic modifica...

journal_title：BioMed research international

authors： Kang M,Kim DC,Liu C,Gao J

更新日期：2015-01-01 00:00:00

abstract：:Bone loss and fractures may call for the use of bone substituting materials, such as calcium phosphate cements (CPCs). CPCs can be degradable, and, to determine their limitations in terms of applications, their mechanical as well as chemical properties need to be evaluated over longer periods of time, under physiologi...

journal_title：BioMed research international

authors： Ajaxon I,Öhman C,Persson C

更新日期：2015-01-01 00:00:00

abstract：:Although the application of patient-specific instruments (PSI) for total knee arthroplasty (TKA) increases the cost of the surgical procedure, PSI may reduce operative time and improve implant alignment, which could reduce the number of revision surgeries. We report our experience with TKA using PSI techniques in 120 ...

journal_title：BioMed research international

authors： Kwon OR,Kang KT,Son J,Choi YJ,Suh DS,Koh YG

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:To investigate the effect of two foot placements (normal or posterior placement) and three arm positions (hands on the thighs, arms crossed over chest, and augmented arm position with elbow extended) on the five times sit-to-stand (FTSTS) test times of individuals with chronic stroke. DESIGN:Cross-sectional...

journal_title：BioMed research international

authors： Kwong PW,Ng SS,Chung RC,Ng GY

更新日期：2014-01-01 00:00:00

abstract：:Mortierella sp. has been known to produce polyunsaturated fatty acids (PUFAs) such as GLA and AA under normal growth medium conditions. Similarly, under the stress condition, this fungus produces EPA and DHA in their mycelial biomass. Among the 67 soil samples screened from the Western Ghats of India, 11 Mortierella i...

journal_title：BioMed research international

authors： Vadivelan G,Venkateswaran G

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:To evaluate HIV risk perception and its associated factors among Chinese MSM. METHODS:A cross-sectional study was conducted among MSM with an HIV negative or unknown status in Beijing, China, between 2011 and 2012. A questionnaire interview was conducted and a blood sample was collected for HIV and syphilis ...

journal_title：BioMed research international

authors： Fan W,Yin L,Qian HZ,Li D,Shao Y,Vermund SH,Ruan Y,Zhang Z

更新日期：2014-01-01 00:00:00

abstract：:Lipids have been widely used as main constituents in various drug delivery systems, such as liposomes, solid lipid nanoparticles, nanostructured lipid carriers, and lipid-based lyotropic liquid crystals. Among them, lipid-based lyotropic liquid crystals have highly ordered, thermodynamically stable internal nanostruct...

journal_title：BioMed research international

authors： Chen Y,Ma P,Gui S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to...

journal_title：BioMed research international

authors： Kulachote N,Sa-ngasoongsong P,Sirisreetreerux N,Chanplakorn P,Fuangfa P,Suphachatwong C,Wajanavisit W

更新日期：2016-01-01 00:00:00

abstract：:A set of optical models associated with blood cells are introduced in this paper. All of these models are made up of different parts possessing symmetries. The wrapped phase images as well as the unwrapped ones from two orthogonal directions related to some of these models are obtained by simulation technique. Because...

journal_title：BioMed research international

authors： Ji Y,Liang M,Hua T,Xu Y,Xin Z,Wang Y

更新日期：2015-01-01 00:00:00

abstract：:Praeruptorins belonging to the angular-type pyranocoumarins are bioactive constituents that have been isolated from some Peucedanum species such as P. praeruptorum, which is used in traditional Chinese medicine for treatment of cold, cough, upper respiratory infections, and so forth. Many reports have demonstrated tha...

journal_title：BioMed research international

authors： Sarkhail P,Shafiee A,Sarkheil P

更新日期：2013-01-01 00:00:00

abstract：:Restriction enzymes are the main defence system against foreign DNA, in charge of preserving genome integrity. Lactococcus raffinolactis BGTRK10-1 expresses LraI Type II restriction-modification enzyme, whose activity is similar to that shown for EcoRI; LraI methyltransferase protects DNA from EcoRI cleavage. The gene...

journal_title：BioMed research international

authors： Miljkovic M,Malesevic M,Filipic B,Vukotic G,Kojic M

更新日期：2018-01-29 00:00:00

abstract：:Aims. We describe a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to quantify and compare simultaneously global methylation and hydroxymethylation in human DNA of different tissues. Materials and Methods. Blood and saliva DNA from fourteen volunteers was processed for epigenetic endpoints using LC-M...

journal_title：BioMed research international

authors： Godderis L,Schouteden C,Tabish A,Poels K,Hoet P,Baccarelli AA,Van Landuyt K

更新日期：2015-01-01 00:00:00

abstract：:Uterine fibroids (UFs) are benign tumors of the reproductive tract, arising from smooth muscle cells of the uterus. Steroid hormones, estrogen, and progesterone are considered to be the most important links in the pathophysiology of UFs. Alpha-tocopherol (AT) is the most active form of vitamin E. What is important as ...

journal_title：BioMed research international

authors： Ciebiera M,Szymańska-Majchrzak J,Sentkowska A,Kilian K,Rogulski Z,Nowicka G,Jakiel G,Tomaszewski P,Włodarczyk M

更新日期：2018-07-24 00:00:00

abstract：:Introduction. The aim of the present study was to determine the closeness of agreement between a self-reported and an objective measure of physical activity in low back pain patients and healthy controls. Beyond, influencing factors on overestimation were identified. Methods. 27 low back pain patients and 53 healthy c...

journal_title：BioMed research international

authors： Schaller A,Rudolf K,Dejonghe L,Grieben C,Froboese I

更新日期：2016-01-01 00:00:00

abstract：:The receptor activator of NF-κB (RANK) pathway is involved in bone health as well as breast cancer (BC) pathogenesis and progression. Whereas the therapeutic implication of this pathway is established for the treatment of osteoporosis and bone metastases, the application in adjuvant BC is currently investigated. As ge...

journal_title：BioMed research international

authors： Hein A,Bayer CM,Schrauder MG,Häberle L,Heusinger K,Strick R,Ruebner M,Lux MP,Renner SP,Schulz-Wendtland R,Ekici AB,Hartmann A,Beckmann MW,Fasching PA

更新日期：2014-01-01 00:00:00

abstract：:Stem cell implantation has been utilized for the repair of spinal cord injury; however, it shows unsatisfactory performance in repairing large scale lesion of an organ. We hypothesized that dental follicle cells (DFCs), which possess multipotential capability, could reconstruct spinal cord defect (SCD) in combination ...

journal_title：BioMed research international

authors： Li X,Yang C,Li L,Xiong J,Xie L,Yang B,Yu M,Feng L,Jiang Z,Guo W,Tian W

更新日期：2015-01-01 00:00:00

abstract：:Combination antiemetic regimens targeting multiple molecular pathways associated with emesis have become the standard of care for prevention of chemotherapy-induced nausea and vomiting (CINV) related to highly and moderately emetogenic chemotherapies. Antiemetic consensus guidelines from several professional societies...

journal_title：BioMed research international

authors： Hesketh PJ,Aapro M,Jordan K,Schwartzberg L,Bosnjak S,Rugo H

更新日期：2015-01-01 00:00:00

abstract：:Purpose. This meta-analysis is to assess the effectiveness of teriparatide in fracture healing and clinical function improvement of the osteoporotic patients. Methods. We searched PubMed, Embase, Web of Science, and the Cochrane databases for randomized and quasi-randomized controlled trials comparing teriparatide to ...

journal_title：BioMed research international

authors： Lou S,Lv H,Wang G,Zhang L,Li M,Li Z,Zhang L,Tang P

更新日期：2016-01-01 00:00:00

abstract：Background:We investigated the potential safety of remimazolam and propofol in malignant hyperthermia- (HM-) susceptible patients using ryanodine receptor 1- (RYR1-) expressing human embryonic kidney- (HEK-) 293 cells. Methods:We compared the enhanced responsiveness of HEK-293 cells expressing wild-type RYR1 with that...

journal_title：BioMed research international

authors： Watanabe T,Miyoshi H,Noda Y,Narasaki S,Morio A,Toyota Y,Kimura H,Mukaida K,Yasuda T,Tsutsumi YM

更新日期：2021-01-04 00:00:00

abstract：Background:The aim of this article is to present a short review of noninvasive, nonpharmacological treatment methods used in somatic illnesses that fall under the umbrella of approach called behavioral medicine. Methods:The narrative review method was applied in the study. Science paper databases, including PubMed, ha...

journal_title：BioMed research international

authors： Białkowska J,Juranek J,Wojtkiewicz J

更新日期：2020-11-03 00:00:00

abstract：:RAW264.7 is a macrophage strain derived from mice tumour and shows a significant ability in antigen uptake. Real-time quantitative PCR (RT-qPCR) is one of the most commonly used methods in gene studies and requires suitable reference genes to normalize and quantitate the expression of gene of interest with sensitivity...

journal_title：BioMed research international

authors： Bao Z,Huang Y,Chen J,Wang Z,Qian J,Xu J,Zhao Y

更新日期：2019-05-16 00:00:00

abstract：:The polyherbal formulation containing Allium sativum L., Terminalia bellirica (Gaertn.) Roxb., Curcuma aeruginosa Roxb., and Amomum compactum Sol ex. Maton has been used for hypertension treatment empirically. Our previous study showed its blood pressure-lowering effect on a rat model of hypertension. However, toxicit...

journal_title：BioMed research international

authors： Sholikhah EN,Mustofa M,Nugrahaningsih DAA,Yuliani FS,Purwono S,Sugiyono S,Widyarini S,Ngatidjan N,Jumina J,Santosa D,Koketsu M

更新日期：2020-03-24 00:00:00

abstract：:The purpose of the present study was to examine the convergent and divergent validity of the Biber Cognitive Estimation Test (BCET) in individuals with ABI undergoing postacute rehabilitation and to assess the measure's ability to account for unique variance in community integration following rehabilitation. Participa...

journal_title：BioMed research international

authors： Fortune DG,Richards HL

更新日期：2017-01-01 00:00:00

abstract：Background:Low birth weight is the leading cause of infant and child mortality and contributes to several poor health outcomes. Proper knowledge of risk factors of low birth weight is important for identifying those mothers at risk and thereby for planning and taking appropriate actions. This study investigates factors...

journal_title：BioMed research international

authors： Hailu LD,Kebede DL

更新日期：2018-04-23 00:00:00

abstract：:In continuance of our search for anticancer agents, we report herein the synthesis and anticancer activity of some novel oxadiazole analogues. The compounds were screened for anticancer activity as per National Cancer Institute (NCI US) protocol on leukemia, melanoma, lung, colon, CNS, ovarian, renal, prostate, and br...

journal_title：BioMed research international

authors： Ahsan MJ,Sharma J,Singh M,Jadav SS,Yasmin S

更新日期：2014-01-01 00:00:00

abstract：:Neonatal respiratory distress syndrome (NRDS) is a common disease that occurs in premature infants. However, the mechanisms underlying the disease remain unclear. microRNAs (miRNAs) have been indicated to play a crucial role in the development of NRDS. In this study, we aimed to explore the regulatory mechanisms of mi...

journal_title：BioMed research international

authors： Zhang YH,Chen AL,Yu RQ,Jia BB,Ye DN,Wang M,Mei YZ,Fang GD,Jiang SY,Zhou Q,Zhang B

更新日期：2021-01-05 00:00:00

abstract：:The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...

journal_title：BioMed research international

authors： Gopalai AA,Lim SY,Chua JY,Tey S,Lim TT,Mohamed Ibrahim N,Tan AH,Eow GB,Abdul Aziz Z,Puvanarajah SD,Viswanathan S,Looi I,Lim SK,Tan LP,Chong YB,Tan CT,Zhao Y,Tan EK,Ahmad-Annuar A

更新日期：2014-01-01 00:00:00

abstract：:Detection of single based genetic mutation by using oligonucleotide probes is one of the common methods of detecting single nucleotide polymorphisms at known loci. In this paper, we demonstrated a hybridization system which included a buffer solution that produced selective salt-induced effect and a locked nucleic aci...

journal_title：BioMed research international

authors： Zhang J,Wu H,Chen Q,Zhao P,Zhao H,Yao W,Wei M

更新日期：2015-01-01 00:00:00

abstract：:Iran is one of the six countries with the most cutaneous leishmaniasis (CL) patients. Understanding better the genotypes of the parasite population in relation to geography and climate is critical to achieving better CL control. We aimed to characterise the population structure of Leishmania tropica, the cause of anth...

journal_title：BioMed research international

authors： Ghatee MA,Mirhendi H,Marashifard M,Kanannejad Z,Taylor WR,Sharifi I

更新日期：2018-06-06 00:00:00

abstract：:The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe dr...

journal_title：BioMed research international

authors： Wang L,Chiang C,Liang H,Wu H,Feng W,Quinney SK,Li J,Li L

更新日期：2015-01-01 00:00:00