Abstract:
:Shigellosis is a global human health problem and the incidence is highest among children. In the present work, main Shigella virulence genes was examined by PCR and compared to symptoms of pediatric shigellosis. Thirty Shigella isolates were identified from an etiologic study at which 1,339 children ranging 0-10 years old were enrolled. S. flexneri was the most frequent species reaching 60.0% of isolates, 22.2% were S. sonnei, and 6.6% were both S. dysenteriae and S. boydii. All Shigella infected children had diarrhea, but not all were accompanied by others symptoms of bacillary dysentery. Among major virulence genes, the PCR typing revealed ipaBCD was present in all isolates, followed by IpaH7.8, set-1A, set-1B, sen/ospD3, virF, and invE. The pathogenic potential of the ShET-1B subunit was observed in relation to dehydration (P < 0.001) and ShET-2 related to the intestinal injury (P = 0.033) evidenced by the presence of bloody diarrhea. Our results show associations among symptoms of shigellosis and virulence genes of clinical isolates of Shigella spp.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
da Cruz CB,de Souza MC,Serra PT,Santos I,Balieiro A,Pieri FA,Nogueira PA,Orlandi PPdoi
10.1155/2014/539697subject
Has Abstractpub_date
2014-01-01 00:00:00pages
539697eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析
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