Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria.

abstract：:Ultrasound tomography (UST) image segmentation is fundamental in breast density estimation, medicine response analysis, and anatomical change quantification. Existing methods are time consuming and require massive manual interaction. To address these issues, an automatic algorithm based on GrabCut (AUGC) is proposed i...

journal_title：BioMed research international

authors： Wu S,Yu S,Zhuang L,Wei X,Sak M,Duric N,Hu J,Xie Y

更新日期：2017-01-01 00:00:00

abstract：:The effects of obstruction on renal function are the consequence of many factors that profoundly alter all components of glomerular function. Besides the acute effects on glomerular filtration rate and tubule function, a chronic obstruction induces tubular and interstitial injury that results from the activation of di...

journal_title：BioMed research international

authors： Lucarelli G,Mancini V,Galleggiante V,Rutigliano M,Vavallo A,Battaglia M,Ditonno P

更新日期：2014-01-01 00:00:00

abstract：:Background. Central systolic blood pressure (CSBP) has prognostic significance and simplified devices for its estimation have been introduced recently. The aim of this study was to assess the achievement of the target CSBP in treated hypertensive patients. Subjects and Methods. One hundred patients with well-controlle...

journal_title：BioMed research international

authors： Bulas J,Potočárová M,Murín J,Kozlíková K,Luha J,Čaprnda M

更新日期：2017-01-01 00:00:00

abstract：:The microbial resistance of fungi and bacteria is currently considered a major public health problem. Esters derived from cinnamic acid have a broad spectrum of pharmacological properties that include antimicrobial activity. In this study, a collection of structurally related 4-chlorocinnamic acid esters was prepared ...

journal_title：BioMed research international

authors： Silva RHN,Andrade ACM,Nóbrega DF,de Castro RD,Pessôa HLF,Rani N,de Sousa DP

更新日期：2019-04-23 00:00:00

abstract：:It is increasingly affirmed that most of the long-term consequences of TBI are due to molecular and cellular changes occurring during the acute phase of the injury and which may, afterwards, persist or progress. Understanding how to prevent secondary damage and improve outcome in trauma patients, has been always a tar...

journal_title：BioMed research international

authors： Mangiola A,Vigo V,Anile C,De Bonis P,Marziali G,Lofrese G

更新日期：2015-01-01 00:00:00

abstract：:The repair of bone defects is a big challenge in reconstructive surgery. Periosteal distraction osteogenesis (PDO), as a promising technique used for bone regeneration, forms a space between the periosteum and bone cortex to regenerate the new bone merely by distracting the periosteum. In order to investigate the infl...

journal_title：BioMed research international

authors： Zhao D,Jiang W,Wang Y,Wang C,Zhang X,Li Q,Han D

更新日期：2020-04-23 00:00:00

abstract：:Approximately 40% of patients admitted to the medical intensive care unit (ICU) require mechanical ventilation. An accurate prediction of successful extubation in patients is a key clinical problem in ICU due to the fact that the successful extubation is highly associated with prolonged ICU stay. The prolonged ICU sta...

journal_title：BioMed research international

authors： Tu CS,Chang CH,Chang SC,Lee CS,Chang CT

更新日期：2018-01-04 00:00:00

abstract：:(124)Iodine ((124)I) with its 4.2 d half-life is particularly attractive for in vivo detection and quantification of longer-term biological and physiological processes; the long half-life of (124)I is especially suited for prolonged time in vivo studies of high molecular weight compounds uptake. Numerous small molecul...

journal_title：BioMed research international

authors： Cascini GL,Niccoli Asabella A,Notaristefano A,Restuccia A,Ferrari C,Rubini D,Altini C,Rubini G

更新日期：2014-01-01 00:00:00

abstract：Introduction:We investigated the proportion of myeloid-derived suppressor cells (MDSCs) and their subsets in patients with rheumatic diseases and clarified the association between these cells and the patient clinical data. Methods:Patients with rheumatic diseases and healthy controls were recruited. The clinical chara...

journal_title：BioMed research international

authors： Zhu J,Chen S,Wu L,Wang R,Zheng S,Zhao D,Wang X,Li J

更新日期：2018-06-26 00:00:00

abstract：Objective:The aim of this study was to investigate the association between adiponectin gene polymorphisms rs10937273, rs1501299, rs182052, rs2241767, and rs266729 and environmental risk factors of type 2 diabetes mellitus (T2DM) in Hohhot. The study explored different models of gene-environment interactions, aimed at p...

journal_title：BioMed research international

authors： Cui M,Gao Y,Zhao Y,Pang H,Chen L,Wang Z,Zhao L,Li M

更新日期：2020-06-21 00:00:00

abstract：:A Chinese medicinal fern Blechnum orientale (Linn) was separately collected from polluted and unpolluted sites to determine whether it could accumulate hazardous pollutants or not. Metal concentrations (Cu, Zn, Mn, Pb, Cd, Cr, As, and Hg) both in the fronds and roots and polycyclic aromatic hydrocarbons (PAHs) in the ...

journal_title：BioMed research international

authors： Zhu XM,Kuang YW,Xi D,Li J,Wang FG

更新日期：2013-01-01 00:00:00

abstract：:Myostatin, a TGF-β family member, is associated with inhibition of muscle growth and differentiation and might interact with the IGF-1 signaling pathway. Since IGF-1 is secreted at a bioactive level by adipose tissue-derived mesenchymal stem cells (ASCs), these cells (ASCs) provide a therapeutic option for Duchenne Mu...

journal_title：BioMed research international

authors： Gehmert S,Wenzel C,Loibl M,Brockhoff G,Huber M,Krutsch W,Nerlich M,Gosau M,Klein S,Schreml S,Prantl L,Gehmert S

更新日期：2014-01-01 00:00:00

abstract：Background:Existing literature suggests that an association exists between coronary artery disease (CAD) and carpal tunnel syndrome (CTS), but few researchers have explored whether CTS is a risk for CAD. Materials and Methods:This large case-control study explored the association between CTS and CAD, using health insu...

journal_title：BioMed research international

authors： Chang YC,Chiang JH,Lay IS,Lee YC

更新日期：2019-03-03 00:00:00

abstract：BACKGROUND:India has one of the highest tuberculosis (TB) burdens globally. However, few studies have focused on TB in young children, a vulnerable population, where lack of early diagnosis results in poor outcomes. METHODS:Young children (≤ 5 years) with suspected TB were prospectively enrolled at a tertiary hospital...

journal_title：BioMed research international

authors： Jain SK,Ordonez A,Kinikar A,Gupte N,Thakar M,Mave V,Jubulis J,Dharmshale S,Desai S,Hatolkar S,Kagal A,Lalvani A,Gupta A,Bharadwaj R

更新日期：2013-01-01 00:00:00

abstract：:Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...

journal_title：BioMed research international

authors： Zhou X,Gao C,Huang W,Yang M,Chen G,Jiang L,Gou F,Feng H,Ai N,Xu Y

更新日期：2014-01-01 00:00:00

abstract：:Vitamin B6 is one of the most versatile cofactors in plants and an essential phytonutrient in the human diet that benefits a variety of human health aspects. Although biosynthesis of the vitamin has been well resolved in recent years, the main research is currently based on Arabidopsis thaliana with very little work d...

journal_title：BioMed research international

authors： Mooney S,Chen L,Kühn C,Navarre R,Knowles NR,Hellmann H

更新日期：2013-01-01 00:00:00

abstract：:Background. Increased metal ion levels following total hip arthroplasty (THA) with metal-on-metal bearings are a highly debated topic. Local soft tissue reactions with chronic pain and systemic side effects such as neuropathy are described. The aim of the current study was to determine the serum metal ion concentratio...

journal_title：BioMed research international

authors： Maurer-Ertl W,Pranckh-Matzke D,Friesenbichler J,Bratschitsch G,Holzer LA,Maier M,Leithner A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Suppressor of cytokine signaling 7 (SOCS7) is a member of the SOCS family and is known to interact with phospholipase Cγ-1 (PLCγ-1), a key downstream mediator of the hepatocyte growth factor (HGF)/C-MET axis. Here, we report our observations of the effect of knocking down SOCS7 gene on the behaviour of breast c...

journal_title：BioMed research international

authors： Sasi W,Ye L,Jiang WG,Sharma AK,Mokbel K

更新日期：2014-01-01 00:00:00

abstract：:Abdominal pregnancy is a very rare form of ectopic pregnancy, associated with high morbidity and mortality for both fetus and mother. It is, and often, seen in poor resource nations, where early diagnosis is often a major challenge due to poor prenatal care and lack of medical resources. An advanced abdominal pregnanc...

journal_title：BioMed research international

authors： Dabiri T,Marroquin GA,Bendek B,Agamasu E,Mikhail M

更新日期：2014-01-01 00:00:00

abstract：:Several studies have compared molecular components between red and white skeletal muscles in mammals. However, mammalian skeletal muscles are composed of mixed types of muscle fibers. In the current study, we analyzed and compared the distributions of titin, lipid, phosphate ions, and fatty acid levels in red and whit...

journal_title：BioMed research international

authors： Wu MP,Chang NC,Chung CL,Chiu WC,Hsu CC,Chen HM,Sheu JR,Jayakumar T,Chou DS,Fong TH

更新日期：2018-11-18 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is characterized by systemic end-organ damage. We investigated the involvement of IRF5, TLR-7, MECP2, STAT4, and TNFSF4 genes and TNF-α, IFN-γ, IL-2, IL-12, IL-6, and IL-10 cytokines in SLE pathogenesis and in organ damage in Jordanian patients. Blood was collected from 51 patients a...

journal_title：BioMed research international

authors： Uzrail AH,Assaf AM,Abdalla SS

更新日期：2019-11-29 00:00:00

abstract：:Revealing the gene regulation networks governing cancer initiation and development is necessary while it remains uncompleted. In recent years, enhancers have been reported to be widely transcribed, resulting in the generation of enhancer RNAs (eRNAs). Previous studies have reported that eRNAs are a subclass of long no...

journal_title：BioMed research international

authors： Liu Y,Ding M,Gao Q,He A,Liu Y,Mei H

更新日期：2018-05-22 00:00:00

abstract：:The LRRK2 gene has been associated with both familial and sporadic forms of Parkinson's disease (PD). The G2019S variant is commonly found in North African Arab and Caucasian PD patients, but this locus is monomorphic in Asians. The G2385R and R1628P variants are associated with a higher risk of developing PD in certa...

journal_title：BioMed research international

authors： Gopalai AA,Lim SY,Chua JY,Tey S,Lim TT,Mohamed Ibrahim N,Tan AH,Eow GB,Abdul Aziz Z,Puvanarajah SD,Viswanathan S,Looi I,Lim SK,Tan LP,Chong YB,Tan CT,Zhao Y,Tan EK,Ahmad-Annuar A

更新日期：2014-01-01 00:00:00

abstract：:Recent reports of retinal stem cells being present in several locations of the adult eye have sparked great hopes that they may be used to treat the millions of people worldwide who suffer from blindness as a result of retinal disease or injury. A population of proliferative cells derived from the ciliary body epithel...

journal_title：BioMed research international

authors： Frøen R,Johnsen EO,Nicolaissen B,Facskó A,Petrovski G,Moe MC

更新日期：2013-01-01 00:00:00

abstract：:The receptor of advanced glycation end products (RAGE) and its ligands are linked to the pathogenesis of coronary artery disease (CAD), and circulating soluble receptor of advanced glycation end products (sRAGE), reflecting the RAGE activity, is suggested as a potential biomarker. Elevated sRAGE levels are reported in...

journal_title：BioMed research international

authors： Jensen LJ,Flyvbjerg A,Bjerre M

更新日期：2015-01-01 00:00:00

abstract：:Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions. During starvation, autophagy is induced in numerous organisms ranging from yeast to mammals, and promotes survival by supplying nutrients and energy. In the...

journal_title：BioMed research international

authors： Kheloufi M,Boulanger CM,Durand F,Rautou PE

更新日期：2014-01-01 00:00:00

abstract：Background:The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal...

journal_title：BioMed research international

authors： Mulatu T,Sintayehu Y,Dessie Y,Deressa M

更新日期：2020-12-29 00:00:00

abstract：:Among other diseases characterized by the onset of cachexia, congestive heart failure takes a place of relevance, considering the high prevalence of this pathology in most European countries and in the United States, and is undergoing a rapid increase in developing countries. Actually, only few models of cardiac cache...

journal_title：BioMed research international

authors： Sala V,Gatti S,Gallo S,Medico E,Cantarella D,Cimino J,Ponzetto A,Crepaldi T

更新日期：2016-01-01 00:00:00

abstract：AIM:Cardiac rehabilitation (CR) is an important part of heart failure (HF) treatment. The aim of this paper was to evaluate if thoracic fluid content (TFC) measured by impedance cardiography (ICG) is a useful parameter for predicting the outcome of CR. METHODS:Fifty HF patients underwent clinical and noninvasive haemo...

journal_title：BioMed research international

authors： Gielerak G,Krzesiński P,Piotrowicz E,Piotrowicz R

更新日期：2013-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a major neurodegenerative disorder for which the etiology and pathogenesis remain as elusive as for Alzheimer's disease. PD appears to be caused by genetic and environmental factors, and pedigree and cohort studies have identified numerous susceptibility genes and loci related to PD. Autoso...

journal_title：BioMed research international

authors： Yang X,Xu Y

更新日期：2014-01-01 00:00:00