Abstract:
:The receptor of advanced glycation end products (RAGE) and its ligands are linked to the pathogenesis of coronary artery disease (CAD), and circulating soluble receptor of advanced glycation end products (sRAGE), reflecting the RAGE activity, is suggested as a potential biomarker. Elevated sRAGE levels are reported in relation to acute ischemia and this review focuses on the role of sRAGE as a biomarker for the acute coronary syndrome (ACS). The current studies demonstrated that sRAGE levels are elevated in relation to ACS, however during a very narrow time period, indicating that the time of sampling needs attention. Interestingly, activation of RAGE may influence the pathogenesis and reflection in sRAGE levels in acute and stable CAD differently.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Jensen LJ,Flyvbjerg A,Bjerre Mdoi
10.1155/2015/815942subject
Has Abstractpub_date
2015-01-01 00:00:00pages
815942eissn
2314-6133issn
2314-6141journal_volume
2015pub_type
杂志文章,评审abstract::A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solv...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/239838
更新日期:2013-01-01 00:00:00
abstract::Tumors and wounds share many similarities including loss of tissue architecture, cell polarity and cell differentiation, aberrant extracellular matrix (ECM) remodeling (Ballard et al., 2006) increased inflammation, angiogenesis, and elevated cell migration and proliferation. Whereas these changes are transient in repa...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/103923
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of docetaxel plus oxaliplatin and capecitabine (DOX) in the first line treatment of advanced gastric adenocarcinoma. METHODS:A total of 37 patients were enrolled into this study, and they received DOX regimen (docetaxel 75 mg/m² and oxaliplatin 130 mg/m² intravenous infusi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/971096
更新日期:2013-01-01 00:00:00
abstract::Extra-intestinal E. coli are emerging as a global threat due to their diffusion as opportunistic pathogens and, above all, to their wide set of antibiotic resistance determinants. There are still many gaps in our knowledge of their origin and spread pathways, although food animals have been adjudicated vehicles for pa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8714975
更新日期:2018-11-18 00:00:00
abstract:BACKGROUND:Perimesencephalic nonaneurysmal subarachnoid hemorrhage (PM-NASAH) is characterized by a benign course compared with aneurysmal SAH. While vasospasm (VS) after aneurysmal SAH is considered responsible for serious complications, VS post-PM-NASAH is not well documented. Our purpose was to characterize the inci...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/371063
更新日期:2013-01-01 00:00:00
abstract::Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic disease associated with accelerated atherosclerosis and increased risk of cardiovascular (CV) disease. AS patients also display a high prevalence of features clustered under the name of metabolic syndrome (MeS). Anti-TNF- α therapy was found to be effecti...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/860651
更新日期:2014-01-01 00:00:00
abstract:Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6848450
更新日期:2020-02-20 00:00:00
abstract:BACKGROUND:Tumor patients and patients after traumas are endangered by a reduced immune defense, and a silver coating on their megaprostheses may reduce their risks of infection. The aim of this study was to determine the silver ion concentration directly measured from the periprosthetic tissue and the influence on the...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/763096
更新日期:2013-01-01 00:00:00
abstract::Endothelial-to-mesenchymal transition (EndMT) emerges as an important source of fibroblasts. MicroRNA let-7 exhibits anti-EndMT effects and fibroblast growth factor (FGF) receptor has been shown to be an important in microRNA let-7 expression. The endogenous antifibrotic peptide N-acetyl-seryl-aspartyl-lysyl-proline (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/696475
更新日期:2014-01-01 00:00:00
abstract:Background:The mechanism of inflammatory reaction after intracerebral hemorrhage remains unclear, which to some extent restrains the therapeutic development of hemorrhagic stroke. The present study attempts to verify whether NLRP6 plays an important role in inflammatory reaction after intracerebral hemorrhage and ident...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/6182464
更新日期:2020-06-07 00:00:00
abstract::Despite good safety records, vaccines given to young children can cause adverse events. We investigated the reported adverse events following immunization (AEFI) of vaccines given to children of less than seven years of age during the first ten years (1998 to 2008) in the state of Rondonia, Brazil. We worked with the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/853083
更新日期:2013-01-01 00:00:00
abstract::Mild cognitive impairment (MCI) refers to a transitional state between normal aging and dementia and is a syndrome with cognitive decline greater than expected for an individual's age and educational level. As a subtype of MCI, amnestic mild cognitive impairment (aMCI) most often leads to Alzheimer's disease. This stu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/920902
更新日期:2014-01-01 00:00:00
abstract::Iodinated contrast (IC) is clinically used in diagnostic and interventional procedures, but its use can result in contrast-induced acute kidney injury (CI-AKI). Chronic kidney disease (CKD) and chronic hyperglycemia (CH) are important predisposing factors to CI-AKI. The aim of this study was to investigate the impact ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3019410
更新日期:2016-01-01 00:00:00
abstract::Microcapsules with entrapped cells hold great promise for repairing bone defects. Unfortunately, the osteoinductivity of microcapsules has been restricted by many factors, among which the deficiency of functional proteins is a significant priority. We potentiated the osteoinductivity of microencapsulated cells via cot...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/435253
更新日期:2015-01-01 00:00:00
abstract:Purpose:It is well known that interstitial photodynamic therapy (iPDT) of large tumors requires effective planning to ensure efficient delivery of therapeutic dose to the target tumors. This should be achieved in parallel with minimal damage to the nearby intact tissues. To that end, clinical iPDT can be attained using...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2061509
更新日期:2020-03-23 00:00:00
abstract:OBJECT:Video-assisted thoracoscopic sympathectomy is a safe, effective, and minimally invasive procedure for primary hyperhidrosis. This study aims to evaluate long-term results and patients' quality of life and investigate potential variables responsible for compensatory sweating after one-stage bilateral single-port ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/348017
更新日期:2013-01-01 00:00:00
abstract:AIM:To investigate the role and mechanism of miR-15b in the proliferation and apoptosis of glioma. METHODS:The miR-15b mimics were transfected into human glioma cells to upregulate the miR-15b expression. Cyclin D1 was determined by both western blotting analysis and luciferase reporter assay. Methylthiazol tetrazoliu...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/687826
更新日期:2014-01-01 00:00:00
abstract::Triglyceride-glucose index (TyG index) is associated with type 2 diabetes mellitus (T2DM), but research on this relationship is limited in Japan. The purpose of this study was to evaluate the correlation between TyG index and the risk of T2DM in the Japanese population. Here, 12732 participants were selected from the ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2947067
更新日期:2020-12-11 00:00:00
abstract::Therapeutic approach for Alzheimer's disease (AD) is still deficient. To find active compounds from herbal medicine is of interest in the alleviation of AD symptoms. This study aimed to investigate the protective effects of Tanshinone IIA (TIIA) on memory performance and synaptic plasticity in a transgenic AD model at...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7631801
更新日期:2016-01-01 00:00:00
abstract::The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the fie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/818656
更新日期:2015-01-01 00:00:00
abstract::Seed inoculation with bacterial consortium was found to increase legume yield, providing a higher growth than the standard nitrogen treatment methods. Alfalfa plants were inoculated by mono- and binary compositions of nitrogen-fixing microorganisms. Their physiological and biochemical properties were estimated. Inocul...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/202597
更新日期:2015-01-01 00:00:00
abstract:Objective:It is sometimes difficult to obtain complete/partial response of large hepatocellular carcinoma (HCC) nodules by trans-arterial chemoembolization/embolization (TACE/TAE). The aim is retrospective investigation of tumor response of large HCC nodules (>7 cm) treated by the new TACE technique, repeated alternate...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9289321
更新日期:2020-01-19 00:00:00
abstract::To evaluate the role of Cystatin C (Cys-C) in tumorigenesis and progression of prostate cancer (PCa), we retrospectively collected the clinical information from the records of 492 benign prostatic hyperplasia (BPH), 48 prostatic intraepithelial neoplasia (PIN), and 173 PCa patients, whose disease was newly diagnosed a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/7450459
更新日期:2017-01-01 00:00:00
abstract:Purpose:To explore the effect of VEGF (vascular endothelial growth factor) on the vasculogenic mimicry (VM) formation of Choroidal Melanoma (CM) through PI3k signal pathway, to find novel targets for CM therapy. Methods:This research investigated the molecular mechanism of VEGF promoting VM formation of CM. First, we ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3909102
更新日期:2019-07-11 00:00:00
abstract::Autoimmune diseases (AD) represent a broad spectrum of chronic conditions that may afflict specific target organs or multiple systems with a significant burden on quality of life. These conditions have common mechanisms including genetic and epigenetics factors, gender disparity, environmental triggers, pathophysiolog...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367359
更新日期:2014-01-01 00:00:00
abstract:Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1673486
更新日期:2020-06-05 00:00:00
abstract::We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/546357
更新日期:2014-01-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::Recent progress in microscopy technologies, biological markers, and automated processing methods is making possible the development of gene expression atlases at cellular-level resolution over whole embryos. Raw data on gene expression is usually very noisy. This noise comes from both experimental (technical/methodolo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/986436
更新日期:2015-01-01 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is one of the most common cancers in the world. Our aim is to identify prognostic biomarkers that contribute to the progression of early stage ccRCC and clarify the mechanism. Here, the mRNA microarray expression profile of ccRCC samples was obtained from Gene Expression Omnibus...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/2064582
更新日期:2020-10-29 00:00:00