Abstract:
:Autophagy, a lysosomal catabolic pathway for long-lived proteins and damaged organelles, is crucial for cell homeostasis, and survival under stressful conditions. During starvation, autophagy is induced in numerous organisms ranging from yeast to mammals, and promotes survival by supplying nutrients and energy. In the early neonatal period, when transplacental nutrients supply is interrupted, starvation-induced autophagy is crucial for neonates' survival. In adult animals, autophagy provides amino acids and participates in glucose metabolism following starvation. In patients with anorexia nervosa, autophagy appears initially protective, allowing cells to copes with nutrient deprivation. However, when starvation is critically prolonged and when body mass index reaches 13 kg/m(2) or lower, acute liver insufficiency occurs with features of autophagic cell death, which can be observed by electron microscopy analysis of liver biopsy samples. In acetaminophen overdose, a classic cause of severe liver injury, autophagy is induced as a protective mechanism. Pharmacological enhancement of autophagy protects against acetaminophen-induced necrosis. Autophagy is also activated as a rescue mechanism in response to Efavirenz-induced mitochondrial dysfunction. However, Efavirenz overdose blocks autophagy leading to liver cell death. In conclusion, in acute liver injury, autophagy appears as a protective mechanism that can be however blocked or overwhelmed.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Kheloufi M,Boulanger CM,Durand F,Rautou PEdoi
10.1155/2014/701064subject
Has Abstractpub_date
2014-01-01 00:00:00pages
701064eissn
2314-6133issn
2314-6141journal_volume
2014pub_type
杂志文章,评审abstract:BACKGROUND:This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. METHODS:Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3125842
更新日期:2017-01-01 00:00:00
abstract::Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/981841
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The present study investigated which type of adenocarcinoma with BAC features was prone to be false-negative on 18F-FDG PET/CT. MATERIALS AND METHODS:A retrospective study was performed on 51 consecutive patients with localized adenocarcinoma with BAC features. CT and PET were assessed for lesion size, GGO per...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/243681
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:Noncardiac chest pain (NCCP) is seen more frequently in young population and in these patients loss of function is evolving in social and professional areas. The aim of the study is to evaluate the levels of anxiety and somatic perception in patients with chest pain presenting to cardiology clinic. METHODS:F...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/896183
更新日期:2014-01-01 00:00:00
abstract::VEGF-NO axis uncoupling is an important pathogenesis for DN. Reduced β2GPI could play a part in VEGF signaling pathway and has a protective effect on diabetic vascular disease. This study investigates the effect of reduced β2GPI on glomerular mesangial cells VEGF-NO axis uncoupling induced by high glucose. Compared to...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/5484731
更新日期:2018-07-18 00:00:00
abstract::Bitterness is an important taste sensation for chickens, which provides useful sensory information for acquisition and selection of diet, and warns them against ingestion of potentially harmful and noxious substances in nature. Bitter taste receptors (T2Rs) mediate the recognition of bitter compounds belonging to a fa...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6301915
更新日期:2019-10-31 00:00:00
abstract:UNLABELLED:The aim of this study was to evaluate the relation between the sensory and anthropometric variables in the quiet standing. METHODS:One hundred individuals (50 men, 50 women; 20-40 years old) participated in this study. For all participants, the body composition (fat tissue, lean mass, bone mineral content, ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/985312
更新日期:2015-01-01 00:00:00
abstract::Majority of gram negative pathogenic bacteria are responsible for extended spectrum β-lactamases (ESBLs) production, which show resistance to some newer generation of antibiotics. The study was aimed at evaluating the prevalence of ESBL and antibiotic susceptibility pattern of Pseudomonas isolates collected during 201...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6068429
更新日期:2016-01-01 00:00:00
abstract::Cervical cancer is one of the malignant tumors that seriously threaten women's health. The mechanism of development needs to be deeply studied. In recent years, lncRNA has been identified as one of the important factors affecting the malignant progression of tumors. In this study, we illustrated the important mechanis...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/4351671
更新日期:2020-01-03 00:00:00
abstract::The large-scale production of cardiomyocytes is a key step in the development of cell therapy and tissue engineering to treat cardiovascular diseases, particularly those caused by ischemia. The main objective of this study was to establish a procedure for the efficient production of cardiomyocytes by reprogramming mes...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/390789
更新日期:2013-01-01 00:00:00
abstract::The aim of this study was to analyze periprocedural and mid-term effect of clopidogrel on platelet function using the VerifyNow P2Y12 point-of-care assay in patients undergoing TAVI. Platelet reactivity was measured at the beginning of the procedure after 300 mg clopidogrel bolus administration and during the follow-u...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/386074
更新日期:2013-01-01 00:00:00
abstract:Background:In peritoneal dialysis (PD) patients, whether angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) could protect residual renal function is still controversial. To assess the effects of ACEIs and ARBs on the residual renal function and cardiovascular (CV) events in perito...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6762029
更新日期:2020-09-23 00:00:00
abstract::Mesenchymal stromal cells (MSCs) are multipotent cells, which can give rise to several cell types including osteoblasts, adipocytes, and chondroblasts. These cells can be found in a variety of adult and fetal tissues, such as bone marrow, adipose tissue, cord blood, and placenta. In recent years, the biological proper...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/216806
更新日期:2014-01-01 00:00:00
abstract::Prior to the "onset of hearing," developing cochlear inner hair cells (IHCs) and primary auditory neurons undergo experience-independent activity, which is thought to be important in retaining and refining neural connections in the absence of sound. One of the major hypotheses regarding the origin of such activity inv...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/367939
更新日期:2014-01-01 00:00:00
abstract:Objective:To compare the effectiveness of arthroscopic partial meniscectomy (APM) and physical therapy (PT) for degenerative meniscus tears. Method:We conducted a literature search through PubMed, Embase, the Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov. Randomized controlled trials in adults...
journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2020/1709415
更新日期:2020-03-03 00:00:00
abstract::We compared the efficacy of intravitreal aflibercept (IVA) to intravitreal ranibizumab (IVR) injections in eyes with diabetic macular edema (DME). The medical records of 49 eyes of 36 patients who were diagnosed with DME and had received IVR and 46 eyes of 40 patients who had received IVA treatment were reviewed. The ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2017/1747108
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:The aim of this study is to describe the robotic assisted transfer device (RATD) and an initial focus group evaluation by end users. The purpose of the device is to aid in the transfers of people with disabilities to and from their electric powered wheelchair (EPW) onto other surfaces. The device can be used fo...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/198476
更新日期:2015-01-01 00:00:00
abstract::One of the female causes of infertility is anovulation which is treatable with gonadotropin hormones. These hormones affect the molecular organization of the uterus such as glycoconjugates that are the first site of contact between the blastocyst and the uterus. The objective of this project was to study the alteratio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/3967427
更新日期:2020-12-04 00:00:00
abstract::Hypoxia plays an essential role in orchestrating Epithelial-mesenchymal transition and promoting metastasis of colorectal cancer. However, the underlying mechanisms are still not well elucidated. Here, we present that hypoxic exposure causes endoplasmic reticulum stress and activates the unfolded protein response path...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5958272
更新日期:2020-01-27 00:00:00
abstract::To establish a reliable isoproterenol induced heart dysfunction fetal rat model and understand the switches of contractile proteins, 45 pregnant rats were divided into 15 mg/kg-once, 15 mg/kg-twice, sham-operated once, sham-operated twice, and control groups. And 18 adult rats were divided into isoproterenol-treated a...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/360687
更新日期:2014-01-01 00:00:00
abstract:Objective:To investigate the effects of arteriovenous thrombolysis combined with mechanical thrombectomy on clinical efficacy, neurological function, and the changes of nerve injury markers of acute cerebral infarct (ACI) patients. Methods:A total of 143 cases with ACI admitted to our hospital from June 2017 to June 2...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/9743075
更新日期:2020-10-09 00:00:00
abstract::Ezrin, coding protein EZR which cross-links actin filaments, overexpresses and involves invasion, metastasis, and poor prognosis in various cancers including esophageal squamous cell carcinoma (ESCC). In our previous study, Ezrin was knock down and analyzed by mRNA expression profile which has not been fully mined. In...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/651954
更新日期:2014-01-01 00:00:00
abstract::[This corrects the article DOI: 10.1155/2019/4370258.]. ...
journal_title:BioMed research international
pub_type: 杂志文章,已发布勘误
doi:10.1155/2020/2049759
更新日期:2020-07-16 00:00:00
abstract::Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potenti...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6456031
更新日期:2016-01-01 00:00:00
abstract::Rapid bone defect filling with normal bone is a challenge in orthopaedics and dentistry. Strontium ranelate (SrRan) has been shown to in vitro decrease bone resorption and increase bone formation, and represents a potential agent with the capacity to accelerate bone defect filling. In this study, bone tibial defects o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/549785
更新日期:2014-01-01 00:00:00
abstract::Saponins are a group of naturally occurring plant glycosides with the features of their strong foam-forming properties and multibiological effects such as antitumor activity. Though Misaponin B, one of the triterpenoid saponins from Madhuca longifolia, is known to have spermicidal and antioxidant activity, the other b...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/5925094
更新日期:2020-02-07 00:00:00
abstract:OBJECTIVE:There is an unmet need for a specific cardiovascular risk (CV) algorithm for rheumatoid arthritis (RA) patients. Lipoprotein data are often not available in RA cohorts but could be obtained from frozen blood samples. The objective of this study was to estimate the storage effect on lipoproteins in long-term (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/930925
更新日期:2014-01-01 00:00:00
abstract::The monoexponential model is widely used in quantitative biomedical imaging. Notable applications include apparent diffusion coefficient (ADC) imaging and pharmacokinetics. The application of ADC imaging to the detection of malignant tissue has in turn prompted several studies concerning optimal experiment design for ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/138060
更新日期:2015-01-01 00:00:00
abstract::Proteinuria is an independent risk factor for end-stage renal disease (ESRD) (Shankland, 2006). Recent studies highlighted the mechanisms of podocyte injury and implications for potential treatment strategies in proteinuric kidney diseases (Zhang et al., 2012). Reactive oxygen species (ROS) are cellular signals which ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2013/839761
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:This study was designed to evaluate the role of maintenance therapy with partially hydrolyzed guar gum (PHGG) after topical application of glyceryl trinitrate (GTN) in the conservative treatment of chronic anal fissure (CAF). METHODS:From all the patients with CAF observed during the study period, 165 subjects...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2014/964942
更新日期:2014-01-01 00:00:00