Lung cancer stem cell lose their stemness default state after exposure to microgravity.

abstract：:Background. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. Objectives. The purpose of this study was to determine the magnitude of Leishmania sp. infection and potenti...

journal_title：BioMed research international

authors： Hoyos CL,Cajal SP,Juarez M,Marco JD,Alberti D'Amato AM,Cayo M,Torrejón I,Cimino RO,Diosque P,Krolewiecki AJ,Nasser JR,Gil JF

更新日期：2016-01-01 00:00:00

abstract：:The present study is designed to determine potential target genes involved in hepatocellular carcinoma (HCC) and provide possible underlying mechanisms of action. Several studies (GSE112790, GSE87630, and GSE56140) from the GEO database looking at molecular characteristics in HCC were screened and analyzed by GEO2R, w...

journal_title：BioMed research international

authors： Mu D,Qin F,Li B,Zhou Q

更新日期：2020-10-05 00:00:00

abstract：:Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...

journal_title：BioMed research international

authors： Jim C,Berkovich S

更新日期：2015-01-01 00:00:00

abstract：:Synovitis plays an important role in the pathogenesis of arthritis, which is closely related to the joint swell and pain of patients. The purpose of this study was to investigate the anti-inflammatory effects of pulsed electromagnetic fields (PEMF) on synovitis and its underlying mechanisms. Destabilization of the med...

journal_title：BioMed research international

authors： Ouyang J,Zhang B,Kuang L,Yang P,Du X,Qi H,Su N,Jin M,Yang J,Xie Y,Tan Q,Chen H,Chen S,Jiang W,Liu M,Luo X,He M,Ni Z,Chen L

更新日期：2020-05-26 00:00:00

abstract：:Bone integrity abnormality and imbalance between bone formation by osteoblasts and bone resorption by osteoclasts are known to result in metabolic bone diseases such as osteoporosis. Silymarin-rich milk thistle extract (MTE) and its component silibinin enhanced alkaline phosphatase activity of osteoblasts but reduced ...

journal_title：BioMed research international

authors： Kim JL,Kim YH,Kang MK,Gong JH,Han SJ,Kang YH

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Given its propensity to metastasize, and lack of effective therapies for most patients with advanced disease, early detection of melanoma is a clinical imperative. Different computer-aided diagnosis (CAD) systems have been proposed to increase the specificity and sensitivity of melanoma detection. Although s...

journal_title：BioMed research international

authors： Jaworek-Korjakowska J,Kłeczek P

更新日期：2016-01-01 00:00:00

abstract：:The complexity and diversity of eukaryotic organisms are a feat of nature's engineering. Pulling the strings of such an intricate machinery requires an even more masterful and crafty approach. Only the number and type of responses that they generate exceed the staggering proportions of environmental signals perceived ...

journal_title：BioMed research international

authors： Bhattacharjee S,Renganaath K,Mehrotra R,Mehrotra S

更新日期：2013-01-01 00:00:00

abstract：:The achievement of successful biostimulation of active microbiomes for the cleanup of a polluted site is strictly dependent on the knowledge of the key microorganisms equipped with the relevant catabolic genes responsible for the degradation process. In this work, we present the characterization of the bacterial commu...

journal_title：BioMed research international

authors： Merlino G,Balloi A,Marzorati M,Mapelli F,Rizzi A,Lavazza D,de Ferra F,Carpani G,Daffonchio D

更新日期：2015-01-01 00:00:00

abstract：:This study aimed to estimate the distribution of hepatitis B virus (HBV) C/D recombinant in Han and Tibet patients with chronic hepatitis B (CHB) and then learn such strain's replication capacity in vivo. A total of 331 serum samples were collected from Han outpatients from Sichuan Province and Tibetan outpatients fro...

journal_title：BioMed research international

authors： Du L,Liu M,Liu M,Zhou T,Cheng X,Liu C,Tang H

更新日期：2017-01-01 00:00:00

abstract：:The biological age (BA) equation is a prediction model that utilizes an algorithm to combine various biological markers of ageing. Different from traditional concepts, the BA equation does not emphasize the importance of a golden index but focuses on using indices of vital organs to represent the senescence of whole b...

journal_title：BioMed research international

authors： Jia L,Zhang W,Jia R,Zhang H,Chen X

更新日期：2016-01-01 00:00:00

abstract：:The purpose of the present study was to examine the convergent and divergent validity of the Biber Cognitive Estimation Test (BCET) in individuals with ABI undergoing postacute rehabilitation and to assess the measure's ability to account for unique variance in community integration following rehabilitation. Participa...

journal_title：BioMed research international

authors： Fortune DG,Richards HL

更新日期：2017-01-01 00:00:00

abstract：:Influences of environmental variables and emulsifiers on lipase production of a Candida viswanathii strain were investigated. The highest lipase activity (101.1 U) was observed at 210 rpm, pH 6.0, and 27.5°C. Other fermentation parameters analyzed showed considerable rates of biomass yield (Y L/S = 1.381 g/g), lipase ...

journal_title：BioMed research international

authors： de Almeida AF,Tauk-Tornisielo SM,Carmona EC

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:We investigated the integron types and their relation with antibiotic resistance among A. baumannii isolates collected from intensive care unit patients, Babol, north of Iran. METHODS:In this cross-sectional study, a total of 73 bronchoalveolar lavage samples were obtained from patients in ICU. Susceptibili...

journal_title：BioMed research international

authors： Deylam Salehi M,Ferdosi-Shahandashti E,Yahyapour Y,Khafri S,Pournajaf A,Rajabnia R

更新日期：2017-01-01 00:00:00

abstract：:Txndc9 (thioredoxin domain containing protein 9) has been shown to be involved in mammalian mitosis; however, its function in mammalian oocyte meiosis remains unclear. In this study, we initially found that Txndc9 is expressed during meiotic maturation of mouse oocytes and higher expression of Txndc9 mRNA and protein ...

journal_title：BioMed research international

authors： Ma F,Hou L,Yang L

更新日期：2017-01-01 00:00:00

abstract：:Schistosomiasis, caused by infection with Schistosoma species, remains an important parasitic zoonosis. Thioredoxin glutathione reductase of Schistosoma japonicum (SjTGR) plays an important role in the development of the parasite and for its survival. Here we present a recombinant plasmid DNA vaccine, pVAX1/SjTGR, to ...

journal_title：BioMed research international

authors： Cao Y,Zhao B,Han Y,Zhang J,Li X,Qiu C,Wu X,Hong Y,Ai D,Lin J,Fu Z

更新日期：2013-01-01 00:00:00

abstract：:Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to ...

journal_title：BioMed research international

authors： Rocha TL,Dias-Junior CA,Possomato-Vieira JS,Gonçalves-Rizzi VH,Nogueira FR,de Souza KM,Braz LG,Braz MG

更新日期：2015-01-01 00:00:00

abstract：:Dengue fever, a reemerging disease, is putting nearly 2.5 billion people at risk worldwide. The number of infections and the geographic extension of dengue fever infection have increased in the past decade. The disease is caused by the dengue virus, a flavivirus that uses mosquitos Aedes sp. as vectors. The disease ha...

journal_title：BioMed research international

authors： De La Guardia C,Lleonart R

更新日期：2014-01-01 00:00:00

abstract：Objective:Neuroimaging studies revealed the functional reorganization or the structural changes during stroke recovery. However, previous studies did not combine the functional and structural information and the results might be affected by heterogeneous lesion. This study aimed to investigate functional activation-inf...

journal_title：BioMed research international

authors： Wu Z,Cheng L,Yang GY,Tong S,Sun J,Miao F

更新日期：2017-01-01 00:00:00

abstract：:The goal of this study was to analyse perceptually and acoustically the voices of patients with Unilateral Vocal Fold Paralysis (UVFP) and compare them to the voices of normal subjects. These voices were analysed perceptually with the GRBAS scale and acoustically using the following parameters: mean fundamental freque...

journal_title：BioMed research international

authors： Jesus LM,Martinez J,Hall A,Ferreira A

更新日期：2015-01-01 00:00:00

abstract：:Retinal vein occlusion (RVO) is a common vascular disease of retina; however, the pathomechanism leading to RVO is not yet clear. In general, increasing age, hypertension, arteriosclerosis, diabetes mellitus, dyslipidemia, cardiovascular disorder, and cerebral stroke are systemic risk factors of RVO. However, RVO ofte...

journal_title：BioMed research international

authors： Kida T

更新日期：2017-01-01 00:00:00

abstract：:Periodontitis is an inflammatory disease involving complex interactions between oral microorganisms and the host immune response. Understanding the structure of the microbiota community associated with periodontitis is essential for improving classifications and diagnoses of various types of periodontal diseases and w...

journal_title：BioMed research international

authors： Chen WP,Chang SH,Tang CY,Liou ML,Tsai SJ,Lin YL

更新日期：2018-11-15 00:00:00

abstract：:Internally symmetric proteins are proteins that have a symmetrical structure in their monomeric single-chain form. Around 10-15% of the protein domains can be regarded as having some sort of internal symmetry. In this regard, we previously published SymD (symmetry detection), an algorithm that determines whether a giv...

journal_title：BioMed research international

authors： Jha A,Flurchick KM,Bikdash M,Kc DB

更新日期：2016-01-01 00:00:00

abstract：:RRM2B gene encodes ribonucleoside-diphosphate reductase subunit M2 B, the p53-inducible small subunit (p53R2) of ribonucleotide reductase (RNR), an enzyme catalyzing dNTP synthesis for mitochondrial DNA. Defects in this gene may cause severe mitochondrial disease affecting mainly the nervous system. This study is aime...

journal_title：BioMed research international

authors： Ait El Cadi C,Krami AM,Charoute H,Elkarhat Z,Sifeddine N,Lakhiari H,Rouba H,Barakat A,Nahili H

更新日期：2020-07-25 00:00:00

abstract：:Alzheimer's disease (AD) is the first most common neurodegenerative disease. Despite a large amount of research, the pathogenetic mechanism of AD has not yet been clarified. The two hallmarks of the pathology of AD are the extracellular senile plaques (SPs) of aggregated amyloid-beta (Aβ) peptide and the accumulation ...

journal_title：BioMed research international

authors： Ou JR,Tan MS,Xie AM,Yu JT,Tan L

更新日期：2014-01-01 00:00:00

abstract：:Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...

journal_title：BioMed research international

authors： Al-Qattan MM

更新日期：2019-09-15 00:00:00

abstract：Objectives:To estimate the prevalence of craniofacial anomalies among Iraqi people and its association with other congenital malformations. Methods:A hospital-based cohort study. It was conducted in Iraq, Fallujah city from Jan 2019-April 2019. The pediatric age group below 16 years attending the consultation clinic. ...

journal_title：BioMed research international

authors： Farhan TM,Al-Abdely BA,Abdullateef AN,Jubair AS

更新日期：2020-08-18 00:00:00

abstract：:We aimed to explore the effects of raloxifene (RAL) on the proliferation and apoptosis of human aortic valve interstitial cells (AVICs). Different concentrations of RAL were used to act on AVICs. MTS kit is used to test the effects of different concentrations of RAL on the proliferation of AVICs. Cell cycle and apopto...

journal_title：BioMed research international

authors： Fu Z,Luo B,Li M,Peng B,Wang Z

更新日期：2016-01-01 00:00:00

abstract：:We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...

journal_title：BioMed research international

authors： Subash S,Essa MM,Al-Asmi A,Al-Adawi S,Vaishnav R

更新日期：2014-01-01 00:00:00

abstract：:This study evaluated the presence of Acanthamoeba species in the Puzih River watershed, which features typical subtropical monsoon climate and is located just above the Tropic of Cancer in Taiwan. The relationship between the seasonal and geographical distributions of Acanthamoeba species in this rivershed was also in...

journal_title：BioMed research international

authors： Kao PM,Chou MY,Tao CW,Huang WC,Hsu BM,Shen SM,Fan CW,Chiu YC

更新日期：2013-01-01 00:00:00

abstract：:The normal physiological loads from muscles experienced by the spine are largely unknown due to a lack of data. The aim of this study is to investigate the effects of varying muscle directions on the outcomes predicted from finite element models of human lumbar spine. A nonlinear finite element model of L3-L5 was empl...

journal_title：BioMed research international

authors： Zhu R,Niu WX,Wang ZP,Pei XL,He B,Zeng ZL,Cheng LM

更新日期：2018-01-03 00:00:00