Abstract:
:Quantitative magnetic resonance imaging (qMRI) is a promising approach to detect early cartilage degeneration. However, there is no consensus on which cartilage component contributes to the tissue's qMRI signal properties. T1, T1ρ, and T2⁎ maps of cartilage samples (n = 8) were generated on a clinical 3.0-T MRI system. All samples underwent histological assessment to ensure structural integrity. For cross-referencing, a discretized numerical model capturing distinct compositional and structural tissue properties, that is, fluid fraction (FF), proteoglycan (PG) and collagen (CO) content and collagen fiber orientation (CFO), was implemented. In a pixel-wise and region-specific manner (central versus peripheral region), qMRI parameter values and modelled tissue parameters were correlated and quantified in terms of Spearman's correlation coefficient ρs. Significant correlations were found between modelled compositional parameters and T1 and T2⁎, in particular in the central region (T1: ρs ≥ 0.7 [FF, CFO], ρs ≤ -0.8 [CO, PG]; T2⁎: ρs ≥ 0.67 [FF, CFO], ρs ≤ -0.71 [CO, PG]). For T1ρ, correlations were considerably weaker and fewer (0.16 ≤ ρs ≤ -0.15). QMRI parameters are characterized in their biophysical properties and their sensitivity and specificity profiles in a basic scientific context. Although none of these is specific towards any particular cartilage constituent, T1 and T2⁎ reflect actual tissue compositional features more closely than T1ρ.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Thüring J,Linka K,Itskov M,Knobe M,Hitpaß L,Kuhl C,Truhn D,Nebelung Sdoi
10.1155/2018/9460456subject
Has Abstractpub_date
2018-05-15 00:00:00pages
9460456eissn
2314-6133issn
2314-6141journal_volume
2018pub_type
杂志文章abstract::Platelets are anuclear cells and are devoid of genomic DNA, but they are capable of de novo protein synthesis from mRNA derived from their progenitor cells, megakaryocytes. There is mounting evidence that microRNA (miRNA) plays an important role in regulating gene expression in platelets. miR-223 is the most abundant ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/981841
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
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doi:10.1155/2014/524940
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journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/165105
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pub_type: 杂志文章,meta分析,评审
doi:10.1155/2015/673103
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pub_type: 杂志文章,评审
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:BioMed research international
pub_type: 杂志文章,meta分析
doi:10.1155/2013/238284
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1155/2020/8835398
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/7901562
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pub_type: 杂志文章
doi:10.1155/2015/158682
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pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2013/340513
更新日期:2013-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,评审
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