The International Prognostic Index for Patients with Chronic Lymphocytic Leukemia Has the Higher Value in Predicting Overall Outcome Compared with the Barcelona-Brno Biomarkers Only Prognostic Model and the MD Anderson Cancer Center Prognostic Index.

abstract：Objectives:Despite the fact that it is widely acknowledged that immune checkpoint inhibitors (ICIs) rely on the presence of immune response to take their antitumor effect, little is known whether there is an influence exerted on the efficacy of ICIs based on patients' age. We performed a systematic review and meta-anal...

journal_title：BioMed research international

authors： Zhang L,Sun L,Yu J,Shan F,Zhang K,Pang X,Ma C,Zhang Y,Shen M,Ma S,Ruan S

更新日期：2019-05-13 00:00:00

abstract：:Natural medical plant is considered as a good source of tyrosinase inhibitors. Red vine leaf extract (RVLE) can be applied to a wide variety of medical disciplines, such as treatments for chronic venous insufficiency over many decades. This study investigated the tyrosinase inhibitory activity of RVLE containing galli...

journal_title：BioMed research international

authors： Lin YS,Chen HJ,Huang JP,Lee PC,Tsai CR,Hsu TF,Huang WY

更新日期：2017-01-01 00:00:00

abstract：:Liver cell culture within three-dimensional structures provides an improved culture system for various applications in basic research, pharmacological screening, and implantable or extracorporeal liver support. Biodegradable calcium-based scaffolds in such systems could enhance liver cell functionality by providing en...

journal_title：BioMed research international

authors： Finoli A,Schmelzer E,Over P,Nettleship I,Gerlach JC

更新日期：2016-01-01 00:00:00

abstract：:This study aims to ascertain whether cytokines in the aqueous humor can predict macular edema (ME) in diabetic patients following uncomplicated phacoemulsification cataract surgery. Undiluted aqueous humor samples were obtained from 136 consecutive type 2 diabetic patients who underwent cataract surgery. The concentra...

journal_title：BioMed research international

authors： Dong N,Xu B,Wang B,Chu L,Tang X

更新日期：2015-01-01 00:00:00

abstract：:1-Deoxynojirimycin (DNJ), the main hypoglycemic constituent in mulberry (Morus alba) latex, has been extensively researched. Although there is considerable interest in the biological effects of DNJ, the roles of 1-deoxynojirimycin (DNJ) in glycometabolism and energy metabolism in insects have received little attention...

journal_title：BioMed research international

authors： Wen CW,Lin XD,Dong MJ,Deng MJ

更新日期：2016-01-01 00:00:00

abstract：:Bone marrow stromal cells (BMSCs) are a valuable resource for skeletal regenerative medicine because of their osteogenic potential. In spite of the very general term "stem cell," this population of cells is far from homogeneous, and different BMSCs clones have greatly different phenotypic properties and, therefore, po...

journal_title：BioMed research international

authors： Vianna VF,Bonfim DC,Cavalcanti Ados S,Fernandes MC,Kahn SA,Casado PL,Lima IC,Murray SS,Murray EJ,Duarte ME

更新日期：2013-01-01 00:00:00

abstract：:The purpose of this study is to evaluate the therapeutic effects of human umbilical cord-derived mesenchymal stem cells (hUC-MSC) activated by curcumin (CUR) on PC12 cells induced by 1-methyl-4-phenylpyridinium ion (MPP+), a cell model of Parkinson's disease (PD). The supernatant of hUC-MSC and hUC-MSC activated by 5 ...

journal_title：BioMed research international

authors： Jinfeng L,Yunliang W,Xinshan L,Yutong W,Shanshan W,Peng X,Xiaopeng Y,Zhixiu X,Qingshan L,Honglei Y,Xia C,Hongwei W,Bingzhen C

更新日期：2016-01-01 00:00:00

abstract：:Ayurvedic and traditional medical practitioners of Sri Lanka use the decoction of the immature inflorescence of Cocos nucifera L. (IC) variety aurantiaca for the treatment of menorrhagia. The progestogenic effect of the ethyl acetate soluble proanthocyanidins (EASPA) of the IC in female rats at a dose of 3.5 mg/kg bod...

journal_title：BioMed research international

authors： Ekanayake CP,Thammitiyagodage MG,Padumadasa S,Seneviratne B,Padumadasa C,Abeysekera AM

更新日期：2019-12-03 00:00:00

abstract：:The aim of this study was to assess the diagnostic accuracy of subjective ultrasound evaluation of myometrial invasion of endometrial cancer and to compare its accuracy to objective methods. All consecutive patients with histologically proven endometrial cancer, who underwent ultrasound evaluation followed by surgical...

journal_title：BioMed research international

authors： Frühauf F,Zikan M,Semeradova I,Dundr P,Nemejcova K,Dusek L,Cibula D,Fischerova D

更新日期：2017-01-01 00:00:00

abstract：:We aimed to assess the prevalence of hospitalization for endometriosis in the general population in France and in each French region and to describe temporal trends, rehospitalization rates, and prevalence of the different types of endometriosis. The analyses were carried out on French hospital discharge data and cove...

journal_title：BioMed research international

authors： von Theobald P,Cottenet J,Iacobelli S,Quantin C

更新日期：2016-01-01 00:00:00

abstract：Methods:In the study, we included 86 children diagnosed with atopic asthma (n = 25), allergic rhinitis (n = 20), and atopic dermatitis (n = 20) and healthy control subjects (n = 21) of Caucasian origin from the Polish population. The blood leukocyte expression of 31 genes involved in neuroinflammatory response (neurotr...

journal_title：BioMed research international

authors： Sobkowiak P,Langwiński W,Nowakowska J,Wojsyk-Banaszak I,Szczepankiewicz D,Jenerowicz D,Wasilewska E,Bręborowicz A,Szczepankiewicz A

更新日期：2020-06-10 00:00:00

abstract：:A dentin-cement-prosthesis complex restored with either all-porcelain, cured resin-composite, or cast base metal alloy and cemented with either of the different resin cements was trimmed into a mini-dumbbell shape for tensile testing. The fractured surfaces and characterization of the dentin-cement interface of bonded...

journal_title：BioMed research international

authors： Piemjai M,Nakabayashi N

更新日期：2015-01-01 00:00:00

abstract：Introduction:The use of blue light-emitting devices (smartphones, tablets, and laptops) at bedtime has negative effects on sleep due to light stimulation and/or problematic excessive use. We aimed to evaluate, among young medical students, if the perception of sleep disturbances due to bedtime use of these devices is c...

journal_title：BioMed research international

authors： Jniene A,Errguig L,El Hangouche AJ,Rkain H,Aboudrar S,El Ftouh M,Dakka T

更新日期：2019-12-24 00:00:00

abstract：:The total knee arthroplasty (TKA) is the gold standard for patients with an advanced symptomatic gonarthrosis. However, there are very few publications dealing with the primary TKA for patients with a proximal tibia fracture. In our retrospective study we evaluated 30 patients treated with a TKA for a proximal tibia f...

journal_title：BioMed research international

authors： Haufe T,Förch S,Müller P,Plath J,Mayr E

更新日期：2016-01-01 00:00:00

abstract：:Trichoderma spp. are important biocontrol filamentous fungi and have tremendous potential in soil bioremediation. In our previous studies, a C2H2 type transcription factor coding gene (thmea1) was cloned from a biocontrol agent T. harzianum Th-33; the encoded sequence of thmea1 contained 3 conserved C2H2 domains with ...

journal_title：BioMed research international

authors： Mei J,Wang L,Jiang X,Wu B,Li M

更新日期：2018-07-18 00:00:00

abstract：BACKGROUND:The prognosis of patients with advanced oropharyngeal carcinoma (OPSCC) is generally poor. The aim of this study is to investigate the different therapeutic approaches and identify prognostic factors associated with a worse outcome for patients treated for T4a OPSCC, in order to improve treatment selection f...

journal_title：BioMed research international

authors： Psychogios G,Mantsopoulos K,Agaimy A,Brunner K,Mangold E,Zenk J,Iro H

更新日期：2014-01-01 00:00:00

abstract：:We have developed a new "drug" and approach that appear to be effective in reducing arterial age. This "drug" represents a low, subtherapeutic dose of statin and sartan and particularly their low-dose combination. The improvement of arterial wall characteristics, also reflecting in a decrease of arterial age, was achi...

journal_title：BioMed research international

authors： Janić M,Lunder M,Šabovič M

更新日期：2015-01-01 00:00:00

abstract：:Sentinel lymph node biopsy (SLNB) emerged in the 1990s as a new technique in the surgical management of the axilla for patients with early breast cancer, resulting in lower complication rates and better quality of life than axillary lymph node dissection (ALND). Today SLNB is firmly established in the armamentarium of...

journal_title：BioMed research international

authors： Assi H,Sbaity E,Abdelsalam M,Shamseddine A

更新日期：2015-01-01 00:00:00

abstract：Background:Drug-induced acute kidney injury (D-AKI) is increasingly common and can extend the hospital length of stay and increase mortality. This study is aimed at analyzing the clinical characteristics of hospitalized patients with D-AKI and the associated risk factors in a multidrug environment. Methods:A retrospec...

journal_title：BioMed research international

authors： Yu C,Guo D,Yao C,Yang H,Liu S,Zhu Y,Kong X

更新日期：2020-09-14 00:00:00

abstract：Purpose:To analyze the keratectasia area (KEA) shown in corneal topography before and after corneal cross-linking (CXL) in patients with progressive keratoconus (KC) and figure out whether KEA is appropriate for evaluating the effect of CXL. Methods:A retrospective analysis was conducted in 34 eyes from 24 progressive...

journal_title：BioMed research international

authors： Wang J,Li Z,Zhang H,Gao N,Mu G

更新日期：2019-04-03 00:00:00

abstract：:New antimicrobial properties of products derived from Humulus lupulus L. such as antiadherent and antibiofilm activities were evaluated. The growth of gram-positive but not gram-negative bacteria was inhibited to different extents by these compounds. An extract of hop cones containing 51% xanthohumol was slightly less...

journal_title：BioMed research international

authors： Rozalski M,Micota B,Sadowska B,Stochmal A,Jedrejek D,Wieckowska-Szakiel M,Rozalska B

更新日期：2013-01-01 00:00:00

abstract：:So far, there is no report regarding the micro-Raman vibrational fingerprint of the bonds between 10-methacryloyloxy-decyl dihydrogen phosphate (10-MDP) and zirconia ceramics. Thus, the aim of this study was to identify the Raman vibrational peaks related to the bonds of 10-MDP with zirconia, as well as the influence ...

journal_title：BioMed research international

authors： De-Paula DM,Loguercio AD,Reis A,Frota NM,Melo R,Yoshihara K,Feitosa VP

更新日期：2017-01-01 00:00:00

abstract：:MicroRNAs orchestrate the expression of the genome and impact many, if not all, cellular processes. Their deregulation is thus often causative of human malignancies, including cancers. Numerous studies have implicated microRNAs in the different steps of tumorigenesis including initiation, progression, metastasis, and ...

journal_title：BioMed research international

authors： Saumet A,Mathelier A,Lecellier CH

更新日期：2014-01-01 00:00:00

abstract：:Lung cancer is one of the most malignant tumors in the world. Early diagnosis and treatment of lung cancer are vitally important to reduce the mortality of lung cancer patients. In the present study, we attempt to identify the candidate biomarkers for lung cancer by weighted gene co-expression network analysis (WGCNA)...

journal_title：BioMed research international

authors： Xu X,Xu L,Huang H,Li J,Dong S,Jin L,Ma Z,Li L

更新日期：2020-06-10 00:00:00

abstract：:This study is aimed at determining how oral squamous cell carcinoma (OSCC) regulates the angiogenesis of HUVECs through miR-210-3p expression and exploring the relationship among miR-210-3p, its target protein, and the possible mechanism of angiogenesis regulation. miR-210-3p expression was detected in OSCC tissues an...

journal_title：BioMed research international

authors： Wang H,Wang L,Zhou X,Luo X,Liu K,Jiang E,Chen Y,Shao Z,Shang Z

更新日期：2020-07-08 00:00:00

abstract：:The prospect of biomaterial hypersensitivity developing in response to joint implant materials was first presented more than 30 years ago. Many studies have established probable causation between first-generation metal-on-metal hip implants and hypersensitivity reactions. In a limited patient population, implant failu...

journal_title：BioMed research international

authors： Mitchelson AJ,Wilson CJ,Mihalko WM,Grupp TM,Manning BT,Dennis DA,Goodman SB,Tzeng TH,Vasdev S,Saleh KJ

更新日期：2015-01-01 00:00:00

abstract：:The white-rot fungus Phanerochaete chrysosporium was investigated for its capacity to degrade the herbicide diuron in liquid stationary cultures. The presence of diuron increased the production of lignin peroxidase in relation to control cultures but only barely affected the production of manganese peroxidase. The her...

journal_title：BioMed research international

authors： Coelho-Moreira Jda S,Bracht A,de Souza AC,Oliveira RF,de Sá-Nakanishi AB,de Souza CG,Peralta RM

更新日期：2013-01-01 00:00:00

abstract：Background:Promoting health-enhancing physical activity following rehabilitation is a well-known challenge. This study analysed the barriers to leisure time activity among low back pain patients. Methods:A subset of 192 low back pain patients who participated in a randomized controlled trial promoting physical activit...

journal_title：BioMed research international

authors： Schaller A,Exner AK,Schroeer S,Kleineke V,Sauzet O

更新日期：2017-01-01 00:00:00

abstract：:Macrophages, especially their activation state, are closely related to the progression of diabetic nephropathy. Classically activated macrophages (M1) are proinflammatory effectors, while alternatively activated macrophages (M2) exhibit anti-inflammatory properties. 1,25-Dihydroxyvitamin D3 has renoprotective roles th...

journal_title：BioMed research international

authors： Zhang X,Zhou M,Guo Y,Song Z,Liu B

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The deregulated tumorigenic long non-coding RNA (lncRNA) has been reported in several malignancies. However, there is still no comprehensive study on tongue squamous cell carcinoma (SCC). METHODS:Functional reannotation for the human lncRNA was carried out by ncFANs. Real-time quantitative PCR was used to v...

journal_title：BioMed research international

authors： Gao W,Chan JY,Wong TS

更新日期：2014-01-01 00:00:00