Expression of melatonin synthesizing enzymes in Helicobacter pylori infected gastric mucosa.

Abstract:

:Helicobacter pylori colonization of gastric mucosa causes pain of unknown etiology in about 15-20% of infected subjects. The aim of the present work was to determine the level of expression of enzymes involved in the synthesis of melatonin in gastric mucosa of asymptomatic and symptomatic H. pylori infected patients. To diagnose H. pylori infection, histological analysis and the urea breath test (UBT C13) were performed. The levels of mRNA expression of arylalkylamine-N-acetyltransferase (AA-NAT) and acetylserotonin methyltransferase (ASMT) were estimated in gastric mucosa with RT-PCR. The level of AA-NAT expression and AMST was decreased in H. pylori infected patients and was increased after H. pylori eradication. We conclude that decreased expression of melatonin synthesizing enzymes, AA-NAT and ASMT, in patients with symptomatic H. pylori infection returns to normal level after H. pylori eradication.

journal_name

Biomed Res Int

authors

Chojnacki C,Popławski T,Blasiak J,Chojnacki J,Reiter RJ,Klupinska G

doi

10.1155/2013/845032

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

845032

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

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