Abstract:
:In spite of the declining incidence of gastric cancer (GC) in recent years, the mortality rate is still high. The asymptomatic nature and nonspecific clinical manifestations combined with the lack of efficient screening programs delay the diagnosis of GC. Therefore, the prevalence of advanced gastric cancer (AGC) has prompted the need for aggressive and intensive treatment options. Among the various treatment options for AGC, surgery is still the mainstay. However, the efficacy of surgery alone is not established. Results from multiple randomized controlled trials suggest that preoperative chemotherapy is promising intervention for the treatment and management of AGC. The main objective of neoadjuvant chemotherapy is to downstage or control micrometastasis in resectable tumor before surgery. On the other hand, conversion chemotherapy refers to surgical treatment aiming at R0 resection after chemotherapy for originally nonresectable or marginally resectable tumors. Nevertheless, preoperative chemoradiotherapy is considered beneficial for AGC patients. Over the last few decades, the combination of chemotherapy and targeted therapy prior to surgery demonstrated great results for the treatment of AGC. The rapid developments in genomics and proteomics have heralded the era of precision medicine. The combination of preoperative chemotherapy and precision medicine may enhance survival in AGC patients.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Xu W,Beeharry MK,Liu W,Yan M,Zhu Zdoi
10.1155/2016/3923585subject
Has Abstractpub_date
2016-01-01 00:00:00pages
3923585eissn
2314-6133issn
2314-6141journal_volume
2016pub_type
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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journal_title:BioMed research international
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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journal_title:BioMed research international
pub_type: 已发布勘误
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/209792
更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
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更新日期:2018-12-03 00:00:00
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journal_title:BioMed research international
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章,评审
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更新日期:2018-10-21 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/6921312
更新日期:2019-02-05 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/256549
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-09 00:00:00
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pub_type: 杂志文章
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更新日期:2018-05-15 00:00:00
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更新日期:2018-08-08 00:00:00