Abstract:
:Several studies suggested that migraine attack onset shows a circadian variation; however, there has not been an overview and synthesis of these findings. A PubMed search with keywords "migraine" AND "circadian" resulted in ten studies directly investigating this topic. Results of these studies mostly show that migraine attacks follow a monophasic 24-hour cyclic pattern with an early morning or late night peak while other studies reported an afternoon peak and also a biphasic 24-hour cycle of attacks. The identified studies showed methodological variation including sample size, inclusion of medication use, comorbidities, and night or shift workers which could have contributed to the contradictory results. Several theories emerged explaining the diurnal distribution of migraine attacks suggesting roles for different phenomena including a morning rise in cortisol levels, a possible hypothalamic dysfunction, a circadian variation of migraine triggers, sleep stages, and a potentially different setting of the circadian pacemaker among migraineurs. At the moment, most studies show an early morning or late night peak of migraine attack onset, but a significant amount of studies reveals contradictory results. Further studies should investigate the arising hypotheses to improve our understanding of the complex mechanism behind the circadian variation of migraine attacks that can shed light on new targets for migraine therapy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Baksa D,Gecse K,Kumar S,Toth Z,Gal Z,Gonda X,Juhasz Gdoi
10.1155/2019/4616417subject
Has Abstractpub_date
2019-08-25 00:00:00pages
4616417eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章,评审abstract::Objective. Our objective is to develop a computerized scheme for liver tumor segmentation in MR images. Materials and Methods. Our proposed scheme consists of four main stages. Firstly, the region of interest (ROI) image which contains the liver tumor region in the T1-weighted MR image series was extracted by using se...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/3219068
更新日期:2016-01-01 00:00:00
abstract::We have determined patient's amyloid subtype through immunohistochemical and proteomic analyses of formalin-fixed, paraffin-embedded (FFPE) tissue samples from two affected organs per patient. Amyloid typing, via immunohistochemistry (IHC) and laser microdissection followed by the combination of liquid chromatography ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/3689091
更新日期:2019-01-31 00:00:00
abstract:INTRODUCTION:This paper presents the final results of a cross-sectional study started in 2010. It compares the perceived efficacy of different types of tobacco health warning (texts versus shocking pictures) to quit or reduce tobacco use. METHODS:The study conducted between 2010 and 2012 in Italy enrolled adults smoke...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/723035
更新日期:2014-01-01 00:00:00
abstract::The objective of the current research was to review and update evidence on the dietary effect of the consumption of tagatose in type 2 diabetes, as well as to elucidate the current approach that exists on its production and biotechnological utility in functional food for diabetics. Articles published before July 1, 20...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/8718053
更新日期:2018-01-09 00:00:00
abstract:BACKGROUND:This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. METHODS:Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneou...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/3125842
更新日期:2017-01-01 00:00:00
abstract::Numerous studies have reported that mesenchymal stem cells (MSCs) can ameliorate neurological deficits in ischemic stroke models. Among the various hypotheses that have been suggested to explain the therapeutic mechanism underlying these observations, neurogenesis is thought to be critical. To enhance the therapeutic ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/129145
更新日期:2014-01-01 00:00:00
abstract::Taenia solium thioredoxin-1 gene (TsTrx-1) has a length of 771 bp with three exons and two introns. The core promoter gene presents two putative stress transcription factor binding sites, one putative TATA box, and a transcription start site (TSS). TsTrx-1 mRNA is expressed higher in larvae than in adult. This gene en...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/453469
更新日期:2015-01-01 00:00:00
abstract::Salinity is a major environmental stress that limits crop production worldwide. In this study, we characterized plant growth-promoting rhizobacteria (PGPR) containing 1-aminocyclopropane-1-carboxylate (ACC) deaminase and examined their effect on salinity stress tolerance in okra through the induction of ROS-scavenging...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6284547
更新日期:2016-01-01 00:00:00
abstract::Microalgae are a promising source of omega-3. The purpose of this study was to extract lipid with a relatively high content of eicosapentaenoic acid (EPA) from Nannochloropsis gaditana using subcritical water extraction (SWE). The effects of different temperatures (156.1-273.9°C), extraction times (6.6-23.4 minutes), ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/8273581
更新日期:2018-12-27 00:00:00
abstract::This study evaluated the efficacy and safety of pulmonary rehabilitation (PR) for pneumoconiosis. We systematically searched PubMed, Embase, The Cochrane Library, Web of Science, SinoMed, CNKI, VIP databases and Wanfang Data from their inception to June 1, 2019. A systematic review and meta-analysis of randomized cont...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/6174936
更新日期:2020-07-28 00:00:00
abstract:OBJECTIVE:There is a paucity of a biological large animal model of myocardial infarction (MI). We hypothesized that, using autologous-aggregated platelets, we could create an ovine model that was reproducible and more closely mimicked the pathophysiology of MI. METHODS:Mepacrine stained autologous platelets from male ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/938047
更新日期:2013-01-01 00:00:00
abstract::GHK (glycyl-L-histidyl-L-lysine) is present in human plasma, saliva, and urine but declines with age. It is proposed that GHK functions as a complex with copper 2+ which accelerates wound healing and skin repair. GHK stimulates both synthesis and breakdown of collagen and glycosaminoglycans and modulates the activity ...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2015/648108
更新日期:2015-01-01 00:00:00
abstract::The availability of an active substance through the skin depends basically on two consecutive steps: the release of this substance from the vehicle and its subsequent permeation through the skin. Hence, studies on the specific properties of vehicles, such as their rheological behavior, are of great interest in the fie...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/818656
更新日期:2015-01-01 00:00:00
abstract:Objective:Primary headache and obesity are highly prevalent disorders in the general population. Although many studies have reported an association between the two, there is still no overall comprehension about this relationship. To gain a more accurate understanding in this regard, we analyzed data from a 2011 cross-s...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/4630490
更新日期:2019-04-15 00:00:00
abstract::This study was conducted to determine the effects of feeding oil palm frond silage based diets with added linseed oil (LO) containing high α -linolenic acid (C18:3n-3), namely, high LO (HLO), low LO (LLO), and without LO as the control group (CON) on the fatty acid (FA) composition of subcutaneous adipose tissue and t...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/194625
更新日期:2013-01-01 00:00:00
abstract::Preterm birth remains the most prevalent cause of neonatal morbidity. This study aimed to evaluate the diagnostic value of SDF-1α, resistin, secretory RAGE (sRAGE), and endogenous secretory RAGE (esRAGE) in preterm labor. A total of 211 pregnant women participated in the study. Group A contained 72 women between 22 an...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/2719460
更新日期:2016-01-01 00:00:00
abstract::The aim of the study was to determine whether different sleep stages, especially REM sleep, affect QT interval duration and variability in male patients without obstructive sleep apnea (OSA). Polysomnographic recordings of 30 patients were analyzed. Beat-to-beat QT interval variability was calculated using QTV index (...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/963028
更新日期:2015-01-01 00:00:00
abstract:Purpose:This study aims to compare the functional outcomes of nonunion humeral diaphyseal fractures following conservative treatment when managed surgically with either a plate or intramedullary (IM) nail fixation. Methods:This was a retrospective study of 56 patients with nonunion humeral fractures following conserva...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/9107898
更新日期:2019-07-22 00:00:00
abstract::The study aims to investigate the effects of the alcohol extract of Coreopsis tinctoria Nutt (AC) on diabetic nephropathy (DN) mice. A total of 30 db/db (DN) mice were divided into 3 groups, which were treated with AC (300 mg/kg/day), metformin (180 mg/kg/day), or saline by gavage for 10 weeks. Ten db/m mice treated w...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/5280514
更新日期:2019-03-28 00:00:00
abstract:OBJECTIVES:To investigate the availability of correction of mandibular plane using software for vertical measurements in cone beam computed tomography (CBCT) according to the sites of the mandible. METHODS:CBCT scans of six dry mandibles were performed at 0-, 5-, 10-, 15-, and 20-degree angles relative to CBCT scannin...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/808625
更新日期:2015-01-01 00:00:00
abstract::The aim of the present study was to investigate the suitability of insoluble Eudragit® water dispersions (NE, NM, RL, and RS) for direct high-shear granulation of very soluble levetiracetam in order to decrease its burst effect from HPMC K100M matrices. The process characteristics, ss-NMR analysis, in vitro dissolutio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2019/8043415
更新日期:2019-03-05 00:00:00
abstract:PURPOSE:To investigate the correlation of outer retinal layers (ORL) thickness and visual acuity (VA) in patients with diabetic macular edema (DME). METHODS:Consecutive DME patients seen at the Retina Clinic of The University of Hong Kong were recruited for OCT assessment. The ORL thickness was defined as the distance...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/981471
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To assess whether high-molecular-weight proteins excretion predicts outcome and therapy-responsiveness in patients with FSGS and nephrotic syndrome. RESEARCH DESIGN AND METHODS:Thirty-eight patients measured at biopsy fractional excretion of IgG (FEIgG) and urinary α2-macroglobulin/creatinine ratio ( α m/C)....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/941831
更新日期:2013-01-01 00:00:00
abstract::Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, active-controlled noninferiority trial between January 1, 2009...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2017/6875968
更新日期:2017-01-01 00:00:00
abstract::Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/989175
更新日期:2014-01-01 00:00:00
abstract::Mycobacterium bovis causes classic bovine tuberculosis, a zoonosis which is still a concern in Africa. Biofilm forming ability of two Mycobacterium bovis strains was assessed on coupons of cement, ceramic, or stainless steel in three different microbiological media at 37°C with agitation for 2, 3, or 4 weeks to determ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/210165
更新日期:2014-01-01 00:00:00
abstract::Emerging evidence shows that microRNAs (miRNAs) play important roles in the regulation of various biological and pathologic processes in human cancers and the aberrant expression of miRNAs contributes to the tumor development. In this study, our findings indicate that miR-451 is significantly overexpressed in pancreat...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2381482
更新日期:2017-01-01 00:00:00
abstract::The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly at...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/485783
更新日期:2014-01-01 00:00:00
abstract::We developed a computational method to identify NAD- and FAD-binding sites in proteins. First, we extracted from the Protein Data Bank structures of proteins that bind to at least one of these ligands. NAD-/FAD-binding residue templates were then constructed by identifying binding residues through the ligand-binding d...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/402536
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Delayed union and nonunion are common complications in atypical femoral fractures (AFFs) despite having good fracture fixation. Demineralized bone matrix (DBM) is a successfully proven method for enhancing fracture healing of the long bone fracture and nonunion and should be used in AFFs. This study aimed to...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2016/4061539
更新日期:2016-01-01 00:00:00