Abstract:
BACKGROUND:This study aimed to analyze differences in necrotic changes between cortical and cancellous bone in resection margins after segmental mandibulectomy for advanced mandibular osteoradionecrosis. METHODS:Anteroposterior bone specimens from eleven patients who underwent segmental mandibulectomy with simultaneous free fibula flap reconstruction for advanced osteoradionecrosis were analyzed histopathologically for the presence of necrotic bone based on the presence of blood vessels within Haversian canals. RESULTS:Ten of eleven (91%) cortices near the inferior border of the mandible at the anterior margins were necrotic. All cancellous bones at the anterior margins were viable. Seven of eleven (64%) cortices near the inferior border of the mandible at the posterior margins were necrotic. Three of eleven (27%) cancellous bones at the posterior margins were necrotic. CONCLUSION:Necrotic changes are more prevalent in cortices than in cancellous bones in mandibular osteoradionecrosis, probably due to a decrease of periosteal blood supply caused by radiotherapy.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Akashi M,Hashikawa K,Wanifuchi S,Kusumoto J,Shigeoka M,Furudoi S,Terashi H,Komori Tdoi
10.1155/2017/3125842subject
Has Abstractpub_date
2017-01-01 00:00:00pages
3125842eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
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