Abstract:
:Immunomodulatory agents have been proposed as therapeutic candidates to improve outcomes in sepsis. Transferon™, a dialyzable leukocyte extract (DLE), has been supported in Mexico as an immunomodulatory adjuvant in anti-infectious therapy. Here we present a retrospective study describing the experience of a referral pediatric intensive care unit (PICU) with Transferon™ in sepsis. We studied clinical and laboratory data from 123 patients with sepsis (15 in the DLE group and 108 in the control group) that were admitted to PICU during the period between January 2010 and December 2016. Transferon™ DLE use was associated with lower C reactive protein (CRP), increase in total lymphocyte counts (TLC), and decrease in total neutrophil count (TNC) 72 hours after Transferon™ DLE administration. The control group did not present any significant difference in CRP values and had lower TLC after 72 hours of admission. There was no difference in PICU length of stay between control and Transferon™ DLE group. Transferon™ DLE administration was associated with a higher survival rate at the end of PICU stay. This study shows a possible immunomodulatory effect of Transferon™ on pediatric sepsis patients.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
Castrejón Vázquez MI,Reséndiz-Albor AA,Ynga-Durand MA,Arciniega Martínez IM,Orellana-Villazon VI,García López CA,Laue Noguera ML,Vargas Camaño MEdoi
10.1155/2019/8980506subject
Has Abstractpub_date
2019-06-23 00:00:00pages
8980506eissn
2314-6133issn
2314-6141journal_volume
2019pub_type
杂志文章abstract:Background:Waldenström macroglobulinemia (WM) is a rare, indolent B-cell lymphoma. Clinically, chromosome 6q deletion (6q del) including loss of the B lymphocyte-induced maturation protein 1 gene (BLIMP-1) is reported to be associated with poor prognosis. However, it remains unclear how the underlying biological mechan...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/6728128
更新日期:2018-10-04 00:00:00
abstract::Dysfunctions of chaperone-mediated autophagy (CMA), the main catabolic pathway for alpha-synuclein, have been linked to the pathogenesis of Parkinson's disease (PD). Since till now there is limited information on how PD-related toxins may affect CMA, in this study we explored the effect of mitochondrial complex I inhi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/846725
更新日期:2013-01-01 00:00:00
abstract:Background:Pakistan is a country with one of the highest burden of tuberculosis (TB) in the world, and therefore, it is imperative to revisit the design of behaviour change interventions in the program. This study was designed to understand and assess the knowledge, awareness, perceptions, and health-seeking behaviour ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1850541
更新日期:2020-04-21 00:00:00
abstract::Endothelial barrier dysfunction, which is a serious problem that occurs in various inflammatory conditions, permits extravasation of serum components into the surrounding tissues, leading to edema formation and organ failure. Pigment epithelium-derived factor (PEDF), which is a major endogenous antagonist, has been im...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/791825
更新日期:2015-01-01 00:00:00
abstract::The purpose of this study was to compare the effect of PbtO2-guided therapy with traditional intracranial pressure- (ICP-) guided treatment on the management of cerebral variables, therapeutic interventions, survival rates, and neurological outcomes of moderate and severe traumatic brain injury (TBI) patients. From 20...
journal_title:BioMed research international
pub_type: 杂志文章,随机对照试验
doi:10.1155/2015/529580
更新日期:2015-01-01 00:00:00
abstract::The regiospecific characteristics of n-3 polyunsaturated fatty acids (PUFAs) in triacylglycerol (TAG) significantly affect the physicochemical and physiological properties of marine fish oils. In this study, the TAG molecular species composition and positional distributions of fatty acids were investigated in three ma...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/3529682
更新日期:2018-07-10 00:00:00
abstract:Background:Musculoskeletal disorders (MSDs) are considered one of the most common health issues in working population and have a high social and economic impact. This study is aimed at determining the MSD patterns and associated risk factors among higher education academicians in Saudi Arabia. Methods:A cross-sectiona...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8930968
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:Cost sharing between beneficiaries and government is critical to attain universal health coverage. The government of Ethiopia introduced social health insurance to improve access to quality health services. Hence, HCP are the ultimate frontline service provider; their WTP for health insurance could influence...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/8412957
更新日期:2020-04-14 00:00:00
abstract::Puffer fishes were collected from the central sea in Vietnam from spring to summer season. The eggs were incubated in MRS broth that was used to test the toxicity in mice and isolate the lactic acid bacteria community that could produce tetrodotoxin (TTX). Thin layer chromatography (TLC) and high performance lipid chr...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/973235
更新日期:2015-01-01 00:00:00
abstract::Objective. This study was aimed at analyzing the expressions of long noncoding RNAs (lncRNAs) in Botulinum Toxin Type A (BoNTA) treated human dermal fibroblasts (HDFs) in vitro. Methods. We used RNA sequencing to characterize the lncRNAs and mRNAs transcriptome in the control and BoNTA treated group, in conjunction wi...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/2957941
更新日期:2017-01-01 00:00:00
abstract::Lung cancer is one of the leading triggers for cancer death worldwide. In this study, the relationship of the aberrantly methylated and differentially expressed genes in lung adenocarcinoma (LUAD) with cancer prognosis was investigated, and 5 feature genes were identified eventually. Specifically, we firstly downloade...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2020/1807089
更新日期:2020-09-25 00:00:00
abstract::Embryology of normal web space creation and the genetics of syndactyly in humans and experimental animals are well described in the literature. In this review, the author offers a 3-step pathway of pathogenesis for syndactyly. The first step is initiated either by the overactivation of the WNT canonical pathway or the...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2019/9652649
更新日期:2019-09-15 00:00:00
abstract::The goal of the present study were (1) to investigate the pathological characteristics of gastrocnemius muscle (GM) and quantitatively assess GM tissue stiffness in rat models with spinal cord injury (SCI) and (2) to explore the correlation between pathological characteristics changes and Young's modulus value of GM. ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2017/5387948
更新日期:2017-01-01 00:00:00
abstract::A role of pro- and antioxidants for reducing rectal cancer (RC) incidence in operative, preoperative, and postoperative treatments is still disputable and controversial. The redox state of venous blood and tissues of blood vessels of 60 patients with RC (T2-4N0-2M0G2) and 20 donors is studied by means of the conventio...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/4848652
更新日期:2018-08-13 00:00:00
abstract::Cerebral malaria (CM) is a severe complication of and a leading cause of death due to Plasmodium falciparum infection. CM is likely the result of interrelated events, including mechanical obstruction due to parasite sequestration in the microvasculature, and upregulation of Th1 immune responses. In parallel, blood-bra...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/292471
更新日期:2014-01-01 00:00:00
abstract::Preformulation is an important step in the rational formulation of an active pharmaceutical ingredient (API). Micromeritics properties: bulk density (BD) and tapped density (TD), compressibility index (Carr's index), Hauser's ratio (H), and sieve analysis were performed in order to determine the best excipients to be ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/307032
更新日期:2015-01-01 00:00:00
abstract::Background. Atrial natriuretic peptide (ANP) considerably influences blood pressure regulation through water and sodium homoeostasis. Several of the studies have utilized anonymous genetic polymorphic markers and made inconsequent claims about the ANP relevant disorders. Thus, we screened Insertion/Deletion (ID) and G...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2016/6712529
更新日期:2016-01-01 00:00:00
abstract::Alzheimer's disease (AD) is a progressive neurodegenerative disorder with two hallmarks: β-amyloid plagues and neurofibrillary tangles. It is one of the most alarming illnesses to elderly people. No effective drugs and therapies have been developed, while mechanism-based explorations of therapeutic approaches have bee...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2014/837157
更新日期:2014-01-01 00:00:00
abstract::Cells of the immune system are highly sensitive to altered gravity, and the monocyte as well as the macrophage function is proven to be impaired under microgravity conditions. In our study, we investigated the surface expression of ICAM-1 protein and expression of ICAM-1 mRNA in cells of the monocyte/macrophage system...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/538786
更新日期:2015-01-01 00:00:00
abstract::Understanding the mechanism behind the structure of the internal cellular clock can lead to advances in the knowledge of origins of pairs of monozygotic twins and higher order multiples as well as other biological phenomena. To gain insight into this mechanism, we analyze possible cell labeling schemes that model an o...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2015/628092
更新日期:2015-01-01 00:00:00
abstract::Oral mucosa is an attractive region for the local and systemic application of many drugs. Oral mucoadhesive films are preferred for their prolonged time of residence, the improved bioavailability of the drug they contain, their painless application, their protection against lesions, and their nonirritating properties....
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/179568
更新日期:2014-01-01 00:00:00
abstract::Carbonic anhydrases (CAs) are enzymes that catalyse the reversible hydration of CO2 to bicarbonate. CA XII is considered a potential biomarker of tumor cells and a promising target for specific therapies. The aim of the current study was to develop new monoclonal antibodies (MAbs) against human recombinant CA XII and ...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/309307
更新日期:2014-01-01 00:00:00
abstract::Plantar fasciitis is a cause of chronic pain under the heel and bottom of the foot. One of the treatments to reduce pain consists of using plantar orthoses to address specific imbalances during foot placement or gait. The aim of the present study was to determine if reduction of pain with a treatment based on plantar ...
journal_title:BioMed research international
pub_type: 临床试验,杂志文章
doi:10.1155/2018/3594150
更新日期:2018-12-12 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) features chronic inflammatory reactions of both intra- and extrapulmonary nature. Moreover, COPD is associated with abnormal glucose and lipid metabolism in patients, which influences the prognosis and chronicity of this disease. Abnormal glucose and lipid metabolism are al...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2020/4574509
更新日期:2020-04-06 00:00:00
abstract::Remote organ impairments are frequent and increase patient morbidity and mortality after lower limb ischemia-reperfusion (IR). We challenged the hypothesis that lower limb IR might also impair lung, renal, and liver mitochondrial respiration. Two-hour tourniquet-induced ischemia was performed on both hindlimbs, follow...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/392390
更新日期:2014-01-01 00:00:00
abstract::Coconut palm (Cocos nucifera) is an important commercial crop in many tropical countries, but its industry generates large amounts of residue. One way to address this problem is to use this residue, coconut husk, to produce second-generation (2G) ethanol. The aim of this review is to describe the methods that have bee...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2018/4916497
更新日期:2018-09-27 00:00:00
abstract::Gold nanoparticles (AuNPs) have several potential biological applications as well as excellent biocompatibility. AuNPs with surface modification using polyethylene glycol (PEG-AuNPs) can facilitate easy conjugation with various biological molecules of interest. To examine the anticancer bioactivity of PEG-AuNPs, we in...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/182353
更新日期:2014-01-01 00:00:00
abstract::We test the hypothesis that ultrasound-targeted microbubble destruction (UTMD) technique increases the renoprotective effect of kidney-targeted transplantation of bone-marrow-derived mesenchymal stem cells (BM-MSCs) in diabetic nephropathy (DN) rats. Diabetes was induced by streptozotocin injection (60 mg/Kg, intraper...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2013/526367
更新日期:2013-01-01 00:00:00
abstract:Background:The purpose of this study was to examine the physical activity patterns and health-related fitness levels of adolescents within the Juvenile Justice System. Methods:Participants included 68 adolescents (Mean age = 17.1 ± 1.0 years) in two secure Juvenile Justice correctional facilities in the Western USA. M...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2018/9710714
更新日期:2018-07-15 00:00:00
abstract::A cross-sectional study was carried out to determine the arsenic (As) and cadmium (Cd) concentrations in blood, urine, and drinking water as well as the health implications on 100 residents in an urban and a rural community. Results showed the blood As, urinary Cd, DNA damage, and water As and Cs were significantly (P...
journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/797603
更新日期:2014-01-01 00:00:00