First trimester biomarkers in the prediction of later pregnancy complications.

Abstract:

:Adverse obstetric outcomes, such as preeclampsia, preterm birth, gestational diabetes, and fetal growth restriction, are poorly predicted by maternal history and risk factors alone, especially in nulliparae. The ability to predict these outcomes from the first trimester would allow for the early initiation of prophylactic therapies, institution of an appropriate model and location of care, and recruitment of a truly "high risk" population to clinical trials of interventions to prevent or ameliorate these conditions. To this end, development of adequately sensitive and specific predictive tests for these outcomes has become a significant focus of perinatal research. This paper reviews the biomarkers involved in these multiparametric tests and also outlines the performance of these tests and issues regarding their introduction into clinical practice.

journal_name

Biomed Res Int

authors

Kane SC,Costa Fda S,Brennecke S

doi

10.1155/2014/807196

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

807196

eissn

2314-6133

issn

2314-6141

journal_volume

2014

pub_type

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