Abstract:
:Our aim was to verify the effects of prednisone related to gastrointestinal motility, intestinal histology, and mucosal mast cells in rats. Two-month-old male Wistar rats were randomly assigned to control group (vehicle) animals receiving saline 0.9% (n = 7) or treated orally with 0.625 mg/kg/day of prednisone (n = 7) or 2.5 mg/kg/day of prednisone (n = 7) during 15 days. Mast cells and other histologic analyses were performed in order to correlate to gastric emptying, cecum arrival, and small intestine transit evaluated by Alternating Current Biosusceptometry. Results showed that prednisone in adult rats increased the frequency of gastric contractions, hastened gastric emptying, slowed small intestinal transit, and reduced mucosal mast cells. Histologically, the treatment with both doses of prednisone decreased villus height, whereas longitudinal and circular muscles and crypt depth were not affected. These findings indicate an impairment of intestinal absorption which may be linked to several GI dysfunctions and symptoms. The relationship between gastrointestinal motor disorders and cellular immunity needs to be clarified in experimental studies since prednisone is one of the most prescribed glucocorticoids worldwide.
journal_name
Biomed Res Intjournal_title
BioMed research internationalauthors
de Lima MB,Gama LA,Hauschildt AT,Dall'Agnol DJR,Corá LA,Americo MFdoi
10.1155/2017/4637621subject
Has Abstractpub_date
2017-01-01 00:00:00pages
4637621eissn
2314-6133issn
2314-6141journal_volume
2017pub_type
杂志文章abstract::Schistosomiasis is the most prevalent tropical disease in the world after malaria. According to the World Health Organization, the disease afflicts more than 240 million people in about 80 countries. Recently, an epidemiological surveillance study performed between 1997 and 2010 by the European Network for Tropical Me...
journal_title:BioMed research international
pub_type: 杂志文章,评审
doi:10.1155/2017/8257310
更新日期:2017-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:BioMed research international
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章,评审
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更新日期:2014-01-01 00:00:00
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更新日期:2014-01-01 00:00:00
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journal_title:BioMed research international
pub_type: 杂志文章
doi:10.1155/2014/963149
更新日期:2014-01-01 00:00:00