Evaluation of plant phenolic metabolites as a source of Alzheimer's drug leads.

abstract：:Targeted drug delivery using folate receptors is one of the most interesting chemotherapeutic research areas over the past few years. A novel folate targeted copolymer was synthesized using dextran stearate coupled to folic acid. FT-IR and NMR spectroscopy were used to confirm successful conjugation. Micelles prepared...

journal_title：BioMed research international

authors： Varshosaz J,Hassanzadeh F,Sadeghi-Aliabadi H,Firozian F

更新日期：2014-01-01 00:00:00

abstract：:Diabetic foot ulcers (DFUs) are characterized by an unsatisfactory inflammatory and migratory response. Skin inflammation involves the participation of many cells and particularly macrophages. Macrophage function can be modulated by neuropeptides; however, little is known regarding the role of neurotensin (NT) as a mo...

journal_title：BioMed research international

authors： Moura LI,Silva L,Leal EC,Tellechea A,Cruz MT,Carvalho E

更新日期：2013-01-01 00:00:00

abstract：:Spinocerebellar ataxia-3 (SCA3) is the most common dominant inherited ataxia worldwide and is caused by an unstable CAG trinucleotide expansion mutation within the ATXN3 gene, resulting in an expanded polyglutamine tract within the ATXN3 protein. Many in vitro studies have examined the role of autophagy in neurodegene...

journal_title：BioMed research international

authors： Ou Z,Luo M,Niu X,Chen Y,Xie Y,He W,Song B,Xian Y,Fan D,OuYang S,Sun X

更新日期：2016-01-01 00:00:00

abstract：:Background. The survival rates of in-hospital cardiac arrests (IHCAs) are reportedly low at night, but the difference between the survival rates of cardiac origin and noncardiac origin IHCAs occurring at night remains unclear. Methods. Outcomes of IHCAs during different shifts (night, day, and evening) were compared a...

journal_title：BioMed research international

authors： Syue YJ,Huang JB,Cheng FJ,Kung CT,Li CJ

更新日期：2016-01-01 00:00:00

abstract：:Small renal masses have been diagnosed increasingly in recent decades, allowing surgical treatment by partial nephrectomy. This treatment option is associated with better renal function preservation, in comparison with radical nephrectomy. However, for obtaining a bloodless field during surgery, occlusion of renal art...

journal_title：BioMed research international

authors： Buys-Gonçalves GF,Abreu LAS,Gregorio BM,Sampaio FJB,Pereira-Sampaio MA,de Souza DB

更新日期：2019-02-07 00:00:00

abstract：:The expression profile of long noncoding RNA (lncRNA) in human epicardial adipose tissue (EAT) has not been widely studied. In the present study, we performed RNA sequencing to analyze the expression profiles of lncRNA and mRNA in EAT in coronary artery disease (CAD) patients with and without heart failure (HF). Our r...

journal_title：BioMed research international

authors： Zheng M,Zhao L,Yang X

更新日期：2019-07-04 00:00:00

abstract：:Macrophages play a key role in immunity. In this review, we consider the traditional notion of macrophage plasticity, data that do not fit into existing concepts, and a hypothesis for existence of a new switch macrophage phenotype. Depending on the microenvironment, macrophages can reprogram their phenotype toward the...

journal_title：BioMed research international

authors： Malyshev I,Malyshev Y

更新日期：2015-01-01 00:00:00

abstract：:Lipases are water-soluble enzymes that act on insoluble substrates and catalyze the hydrolysis of long-chain triglycerides. Lipases play a vital role in the food, detergent, chemical, and pharmaceutical industries. In the past, fungal lipases gained significant attention in the industries due to their substrate specif...

journal_title：BioMed research international

authors： Gopinath SC,Anbu P,Lakshmipriya T,Hilda A

更新日期：2013-01-01 00:00:00

abstract：:We assessed the changes in the plasma Aβ, oxidative stress/antioxidants, and membrane bound enzymes in the cerebral cortex and hippocampus of Alzheimer's disease (AD) transgenic mice (Tg2576) after dietary supplementation of Omani figs fruits for 15 months along with spatial memory and learning test. AD Tg mice on con...

journal_title：BioMed research international

authors： Subash S,Essa MM,Al-Asmi A,Al-Adawi S,Vaishnav R

更新日期：2014-01-01 00:00:00

abstract：:Mitochondrial heat shock proteins, such as HSP60, are chaperones responsible for the folding, transport, and quality control of mitochondrial matrix proteins and are essential for maintaining life. Both prosurvival and proapoptotic roles have been proposed for HSP60, and HSP60 is reportedly involved in the initiation ...

journal_title：BioMed research international

authors： Chen TH,Liu SW,Chen MR,Cho KH,Chen TY,Chu PH,Kao YY,Hsu CH,Lin KM

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Although expression of miR-200s is aberrant in liver fibrosis, its role in liver fibrogenesis still remains unknown. Here, we investigated the role of miR-200c in the activation of human hepatic stellate cells (HSCs) and induction of liver fibrosis. METHODS:We engineered human HSCs (LX2 cell line) to stably...

journal_title：BioMed research international

authors： Ma T,Cai X,Wang Z,Huang L,Wang C,Jiang S,Hua Y,Liu Q

更新日期：2017-01-01 00:00:00

abstract：:Here we wanted to investigate predictive value of neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) in the diagnosis of brucellosis. Thirty-two brucellosis patients diagnosed with positive serum agglutination test and thirty-two randomized healthy subjects were enrolled in this study retrospectivel...

journal_title：BioMed research international

authors： Olt S,Ergenç H,Açıkgöz SB

更新日期：2015-01-01 00:00:00

abstract：:Until now, the chemical bonding between titanium and bone has been examined only through a few mechanical detachment tests. Therefore, in this study, a sandblasted and acid-etched titanium mini-implant was removed from a human patient after 2 months of placement in order to identify the chemical integration mechanism ...

journal_title：BioMed research international

authors： Kim JS,Kang SM,Seo KW,Nahm KY,Chung KR,Kim SH,Ahn JP

更新日期：2015-01-01 00:00:00

abstract：:Schistosomiasis is one of the world's major public health problems. Praziquantel is currently the only effective drug against schistosomiasis. As resistance of praziquantel has emerged in some endemic areas, development of new antischistosomal agents should be a high priority. In this study, a phage display peptide li...

journal_title：BioMed research international

authors： Song LJ,Li JH,Yin XR,Zhang W,Jin Y,Gao H,Wang J,Yu CX,Hua ZC

更新日期：2018-06-05 00:00:00

abstract：Objectives:The aim of this study was to evaluate the influence of ferule and the post type on the fracture strength and stress distribution in premolars. Materials and Methods:Forty human mandibular premolars were decoronated, allocated in four groups, and restored as follows: CPC-NF: cast post-and-core and absence of...

journal_title：BioMed research international

authors： Bacchi A,Caldas RA,Schmidt D,Detoni M,Matheus Albino Souza,Cecchin D,Farina AP

更新日期：2019-01-03 00:00:00

abstract：Aims:The purpose of this study was to describe the challenge of cross-cultural care encounters from perspective of imported nurses in Lhasa, Tibet, as well as investigate the relationship of cross-cultural care encounters and its influencing factors. Methods:A cross-sectional survey was designed among 300 imported nur...

journal_title：BioMed research international

authors： Bai M,Sui X,Zhou C,Li Y,Li J,Gao R,Du Z,Xu L,Li F

更新日期：2020-04-08 00:00:00

abstract：:Since 2001 the Istituto Superiore di Sanità established a quality assurance programme for molecular genetic testing that covers four pathologies: Cystic Fibrosis (CF), Beta Thalassemia (BT), Fragile X Syndrome (FX), and Familial Adenomatous Polyposis Coli (APC). Since 2009 this activity is an institutional activity an...

journal_title：BioMed research international

authors： Censi F,Tosto F,Floridia G,Marra M,Salvatore M,Baffico AM,Grasso M,Melis MA,Pelo E,Radice P,Ravani A,Rosatelli C,Resta N,Russo S,Seia M,Varesco L,Falbo V,Taruscio D

更新日期：2013-01-01 00:00:00

abstract：Background:Preeclampsia (PE) is a pregnancy-specific hypertension syndrome and is one of the leading causes of maternal and perinatal morbidity and mortality. Long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in many diseases, including preeclampsia. The present study is aimed at identifying t...

journal_title：BioMed research international

authors： Zhang Z,Wang P,Zhang L,Huang C,Gao J,Li Y,Yang B

更新日期：2020-06-05 00:00:00

abstract：Objective:To observe the effect of adenosine A1 receptor in the hippocampus of mice on GSK-3β phosphorylation level and elucidate the underlying mechanisms of electroacupuncture pretreatment by activating Α1 receptor mediating cerebral ischemia-reperfusion injury. Method:The model of middle cerebral artery occlusion (...

journal_title：BioMed research international

authors： Geng W,Cai L,Han K,Li D,Mo Y,Dai Q,Tang H,Zhang M,Akuetteh PDP,Balelang MF,Wang J

更新日期：2020-02-20 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by bone loss. Degree of inflammation has been identified as an important initiator of skeletal damage in RA. Iguratimod (T-614) is an anti-inflammatory agent which has been reported to show the inhibitory effect of bone destruction in RA. Ho...

journal_title：BioMed research international

authors： Song J,Liu H,Zhu Q,Miao Y,Wang F,Yang F,Cheng W,Xi Y,Niu X,He D,Chen G

更新日期：2018-02-19 00:00:00

abstract：BACKGROUND AND PURPOSE:The vasoconstrictor endothelin-1 (ET-1) has been implicated in the pathogenesis of cerebral vasospasm following subarachnoid hemorrhage (SAH). Previous results showed that CGS 26303, an endothelin converting enzyme (ECE) inhibitor, effectively prevented and reversed arterial narrowing in animal m...

journal_title：BioMed research international

authors： Wang CJ,Lee PY,Wu BN,Wu SC,Loh JK,Tsai HP,Chung CL,Kassell NF,Kwan AL

更新日期：2014-01-01 00:00:00

abstract：:Destruction of extracellular matrix (ECM) is one of the basic steps of tumor invasion and metastasis. Matrix metalloproteinase (MMP) 9, a kind of zinc-ion-dependent endopeptidase, can degrade almost all protein components in the ECM, destroy the histological barrier of tumor cell invasion, and play a key role in tumor...

journal_title：BioMed research international

authors： Wen J,Yin P,Li L,Kang G,Ning G,Cao Y,Gao F,Su Y,Wu Y,Zhang X

更新日期：2020-04-15 00:00:00

abstract：:Progression of idiopathic dilated cardiomyopathy (IDCM) is marked with extensive left ventricular remodeling whose clinical manifestations and molecular basis are poorly understood. We aimed to evaluate the clinical potential of titin ligands in monitoring progression of cardiac remodeling associated with end-stage ID...

journal_title：BioMed research international

authors： Bogomolovas J,Brohm K,Čelutkienė J,Balčiūnaitė G,Bironaitė D,Bukelskienė V,Daunoravičus D,Witt CC,Fielitz J,Grabauskienė V,Labeit S

更新日期：2015-01-01 00:00:00

abstract：Background:Though there are several prognostic models, there is no protein-related prognostic model. The aim of this study is to identify possible prognostic-related proteins in bladder urothelial carcinoma and to try to predict the prognosis of bladder urothelial carcinoma based on these proteins. Methods:Profile dat...

journal_title：BioMed research international

authors： Luo Q,Zhang X

更新日期：2020-07-31 00:00:00

abstract：:Cognitive decline impacts older adults, particularly their independence. The goal of this project was to increase understanding of how short-term, everyday lifestyle options, including physical activity, help an older adult sustain cognitive independence. Using a secondary analysis of lifestyle choices, we drew on a d...

journal_title：BioMed research international

authors： Howard EP,Morris JN,Steel K,Strout KA,Fries BE,Moore A,Garms-Homolová V

更新日期：2016-01-01 00:00:00

abstract：:Gastric cancer (GC) is one of the most common and fatal malignancies worldwide. MicroRNAs (miRNAs) play a critical role in tumor initiation, proliferation, and metastasis of gastric cancer. miR193b has been identified as a tumor suppressor in a variety of tumor types; however, its role in gastric cancer is yet to be d...

journal_title：BioMed research international

authors： Tian R,Jiang H,Shao L,Yu Y,Guo Q,Cao B,Guo S

更新日期：2020-05-25 00:00:00

abstract：AIM:To investigate the role and mechanism of miR-15b in the proliferation and apoptosis of glioma. METHODS:The miR-15b mimics were transfected into human glioma cells to upregulate the miR-15b expression. Cyclin D1 was determined by both western blotting analysis and luciferase reporter assay. Methylthiazol tetrazoliu...

journal_title：BioMed research international

authors： Sun G,Shi L,Yan S,Wan Z,Jiang N,Fu L,Li M,Guo J

更新日期：2014-01-01 00:00:00

abstract：:Germacrone, a natural 10-membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine Saussurea costus (SC). The pharmacological value and intrinsic mechanism of germacrone in the treatment of esophageal squamous cell carcinoma (ESCC) are still unc...

journal_title：BioMed research international

authors： Zhang R,Hao J,Guo K,Liu W,Yao F,Wu Q,Liu C,Wang Q,Yang X

更新日期：2020-01-30 00:00:00

abstract：:How to decrease intraoperative bleeding, shorten surgical time, and increase safety in spinal surgery is an important issue. Ultrasonic bone removers and FloSeal have been proven to increase safety, reduce the surgical duration, and decrease intraoperative bleeding in skull base surgery. Therefore, we aimed to compare...

journal_title：BioMed research international

authors： Chen HT,Hsu CC,Lu ML,Chen SH,Chen JM,Wu RW

更新日期：2019-05-19 00:00:00

abstract：:Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is characterized by muscular wasting caused by dystrophin deficiency that ultimately ends in force reduction and premature death. In addition to primary genetic defect, several mechanisms contribute to DMD pathogenesis. Recently, antioxidan...

journal_title：BioMed research international

authors： Sitzia C,Farini A,Colleoni F,Fortunato F,Razini P,Erratico S,Tavelli A,Fabrizi F,Belicchi M,Meregalli M,Comi G,Torrente Y

更新日期：2015-01-01 00:00:00