Multimodality molecular imaging of stem cells therapy for stroke.

Abstract:

:Stem cells have been proposed as a promising therapy for treating stroke. While several studies have demonstrated the therapeutic benefits of stem cells, the exact mechanism remains elusive. Molecular imaging provides the possibility of the visual representation of biological processes at the cellular and molecular level. In order to facilitate research efforts to understand the stem cells therapeutic mechanisms, we need to further develop means of monitoring these cells noninvasively, longitudinally and repeatedly. Because of tissue depth and the blood-brain barrier (BBB), in vivo imaging of stem cells therapy for stroke has unique challenges. In this review, we describe existing methods of tracking transplanted stem cells in vivo, including magnetic resonance imaging (MRI), nuclear medicine imaging, and optical imaging (OI). Each of the imaging techniques has advantages and drawbacks. Finally, we describe multimodality imaging strategies as a more comprehensive and potential method to monitor transplanted stem cells for stroke.

journal_name

Biomed Res Int

authors

Chao F,Shen Y,Zhang H,Tian M

doi

10.1155/2013/849819

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

849819

eissn

2314-6133

issn

2314-6141

journal_volume

2013

pub_type

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