Abstract：
:Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short- and long-term outcome. There is a considerable collection of observational data showing substantial improvement in patients with significant left ventricular dysfunction when the need for revascularization is guided by preoperative assessment of viability and hibernation. However, a major challenge for present cardiovascular imaging is to identify better ways to assess viable but inadequately perfused myocardium and thus optimize selection of patients for coronary revascularization. Several non-invasive techniques have been developed to detect signs of viability. Hence, our aim is to provide the reader a state-of-the art review for the assessment of myocardial viability.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Jamiel A,Ebid M,Ahmed AM,Ahmed D,Al-Mallah MHdoi
10.1007/s10741-017-9626-3subject
Has Abstractpub_date
2017-07-01 00:00:00pages
401-413issue
4eissn
1382-4147issn
1573-7322pii
10.1007/s10741-017-9626-3journal_volume
22pub_type
杂志文章,评审abstract：:Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its morbidity and mortality. Cardiac fibroblast is the keystone of fibrogenesis, being activated by numerous cellular and humoral factors. Macrophages, CD4+ and CD8+ T cells, mast cells, and endothelial cells stimulate fibrogenesis dir...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09940-0
更新日期：2020-03-13 00:00:00
abstract：:Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9653-0
更新日期：2018-01-01 00:00:00
abstract：:Pulmonary hypertension that develops in the setting of underlying lung diseases such as COPD or idiopathic pulmonary fibrosis (IPF) is associated with decreased functional status, worsening hypoxemia and quality of life, and increased mortality. This complication of lung disease is complex in its origin and carries a ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-016-9551-x
更新日期：2016-05-01 00:00:00
abstract：:Acute heart failure hospitalizations complicated by diuretic resistance are associated with worse outcomes. Yet, quantification of the frequency and accompanying risk from loop diuretic resistance is limited by the absence of a comprehensive definition with universal clinical application. Herein, we outline limitation...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09851-9
更新日期：2020-01-01 00:00:00
abstract：:The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9225-z
更新日期：2012-03-01 00:00:00
abstract：:Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human body. It is a serious disease burden worldwide affecting nearly 23 million patients. The concept that he...
journal_title：Heart failure reviews
pub_type： 杂志文章
doi：10.1007/s10741-018-9713-0
更新日期：2019-01-01 00:00:00
abstract：:Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9081-2
更新日期：2009-03-01 00:00:00
abstract：:Loss of cardiomyocytes occurs with aging and contributes to cardiovascular complications. In the present study, we highlighted the role of clusterin, a protein that has recently been associated with the protection of cardiomyocytes from apoptosis. Clusterin protects cardiac cells against damage from myocardial infarct...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9654-z
更新日期：2018-01-01 00:00:00
abstract：:Due to the recent advances in diagnosis and management of patients with HER2-positive breast cancer, especially through novel HER2-targeted agents, cardiotoxicity becomes an emerging problem. Although chemotherapy significantly increases survival, the risk of cardiovascular disease development is high and still undere...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10072-8
更新日期：2021-01-06 00:00:00
abstract：:Myocarditis (MCD) is a type of inflammatory disease in which inflammatory cells infiltrate the myocardium, leading to cardiac dysfunction, myocardial necrosis, and fibrosis. Although it has been reported that MCD is mediated by T cells, the immune system is complex and includes many types of immune cells that interact...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09799-w
更新日期：2019-11-01 00:00:00
abstract：:This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect on the binding of T3 to thyroid ho...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9131-9
更新日期：2010-03-01 00:00:00
abstract：:Dilated cardiomyopathy (DCM) is a common debilitating condition with limited therapeutic options besides heart transplantation or palliation. It is characterized by maladaptive remodeling of cardiomyocytes, extracellular collagen matrix (ECCM) and left ventricular (LV) geometry which contributes to further dysfunction...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9300-8
更新日期：2012-09-01 00:00:00
abstract：:The sympathetic nervous system provides the most powerful stimulation of cardiac function, brought about via norepinephrine and epinephrine and their postsynaptic beta-adrenergic receptors. More than 30 years after the first use of practolol in patients with heart failure beta blockers are now the mainstay of the phar...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9132-8
更新日期：2009-12-01 00:00:00
abstract：:Evidence-based management has improved long-term survival in patients with heart failure (HF). However, an unintended consequence of increased longevity is that patients with HF are exposed to a greater symptom burden over time. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suf...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-016-9581-4
更新日期：2017-01-01 00:00:00
abstract：:Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-009-9137-y
更新日期：2010-01-01 00:00:00
abstract：:The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are freq...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9123-9
更新日期：2010-07-01 00:00:00
abstract：:There is little doubt that the discovery of ischemic preconditioning (PC) has been one of the fundamental milestones in the field of ischemic biology in the past 20 years. The purpose of this article is to review the pathophysiology and molecular basis of the late phase of myocardial PC. The exploitation of late PC fo...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9031-4
更新日期：2007-12-01 00:00:00
abstract：:Recent cardiovascular outcome trials have highlighted the propensity of the antidiabetic agents, SGLT2 inhibitors (SGLT2is or -flozin drugs), to exert positive clinical outcomes in patients with cardiovascular disease at risk for major adverse cardiovascular events (MACEs). Of interest in cardiac diabetology is the ph...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09996-y
更新日期：2020-06-24 00:00:00
abstract：:Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-015-9475-x
更新日期：2015-07-01 00:00:00
abstract：:Stem cell therapy is a promising approach to the treatment of ischemic heart disease via replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials have indicated that cardiac function improved consistently, but very modestly after cell-based therapy. This mainly attributed to low...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-016-9576-1
更新日期：2016-11-01 00:00:00
abstract：:Chronic heart failure (CHF) is a multi-dimensional and complex syndrome. Outcome measures are important for determining both the efficacy and quality of care and capturing the patient's perspective in evaluating the outcomes of health care delivery. Capturing the patient's perspective via patient-reported outcomes is ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9369-0
更新日期：2014-03-01 00:00:00
abstract：:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger popu...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9282-y
更新日期：2012-09-01 00:00:00
abstract：:Cardiac magnetic resonance spectroscopy (MRS) is a noninvasive method to assess by-products of myocardial metabolism. Recent developments in shorter scan protocols and more powerful field strengths have created interest in utilizing this technology in studying and characterizing the metabolic derangements in heart fai...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9611-x
更新日期：2017-07-01 00:00:00
abstract：:Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9112-z
更新日期：2009-09-01 00:00:00
abstract：:Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they al...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9646-z
更新日期：2017-11-01 00:00:00
abstract：:The spectrum of ischemic heart diseases, encompassing acute myocardial infarction to heart failure, represents the leading cause of death worldwide. Although extensive progress in cardiovascular diagnoses and therapy has been made, the prevalence of the disease continues to increase. Cardiac regeneration has a promisi...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09953-9
更新日期：2020-04-18 00:00:00
abstract：:We aimed to study the cardiovascular and economic burden of diabetes mellitus (DM) in patients hospitalized for heart failure (HF) in the US and to assess the recent temporal trend. Data from the National Inpatient Sample were analyzed between 2005 and 2014. The prevalence of DM increased from 40.4 to 46.5% in patient...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10012-6
更新日期：2020-09-15 00:00:00
abstract：:Uric acid, the metabolic mediator of gout and urate renal stones, is associated with increased cardiovascular risk burden. Hyperuricemia is an old emerging metabolic disorder, and interaction among uric acid and cardiovascular diseases has been clearly described. Several illness including hypertension, myocardial infa...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09869-z
更新日期：2020-01-01 00:00:00
abstract：:There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-016-9569-0
更新日期：2016-11-01 00:00:00
abstract：:The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidenc...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1011405926588
更新日期：2001-03-01 00:00:00
