Advanced glycation end-products, a pathophysiological pathway in the cardiorenal syndrome.

Abstract:

:The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients with diabetes mellitus and in patients with renal failure. Through the formation of collagen crosslinks, and by interaction with the AGE-receptor, which impairs calcium handling and increases fibrosis, AGE-accumulation has pathophysiologically been associated with the development of diastolic and renal dysfunction. Interestingly, diastolic dysfunction is a frequent finding in elderly patients, diabetic patients and in patients with renal failure. Taken together, this suggests that AGEs are related to the development and progression of diastolic HF and renal failure. In this review, the role of AGEs as a possible pathophysiological factor that link the development and progression of heart and renal failure, is discussed. Finally, the role of AGE intervention as a possible treatment in HF patients will be discussed.

journal_name

Heart Fail Rev

journal_title

Heart failure reviews

authors

Willemsen S,Hartog JW,Heiner-Fokkema MR,van Veldhuisen DJ,Voors AA

doi

10.1007/s10741-010-9225-z

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

221-8

issue

2

eissn

1382-4147

issn

1573-7322

journal_volume

17

pub_type

杂志文章,评审
  • Diagnostic value of echocardiographic markers for diastolic dysfunction and heart failure with preserved ejection fraction.

    abstract::This study aimed to evaluate the diagnostic performance of echocardiographic markers of heart failure with preserved ejection fraction (HFpEF) and left ventricular diastolic dysfunction (LVDD) in comparison with the gold standard of cardiac catheterization. Diagnosing HFpEF is challenging, as symptoms are non-specific...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09985-1

    authors: Dal Canto E,Remmelzwaal S,van Ballegooijen AJ,Handoko ML,Heymans S,van Empel V,Paulus WJ,Nijpels G,Elders P,Beulens JW

    更新日期:2020-06-02 00:00:00

  • The role of myocardial viability in contemporary cardiac practice.

    abstract::Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-017-9626-3

    authors: Jamiel A,Ebid M,Ahmed AM,Ahmed D,Al-Mallah MH

    更新日期:2017-07-01 00:00:00

  • Pharmacological treatment of chronic heart failure.

    abstract::Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The ma...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-006-9482-z

    authors: Adorisio R,De Luca L,Rossi J,Gheorghiade M

    更新日期:2006-06-01 00:00:00

  • Anti-fibrotic effects of curcumin and some of its analogues in the heart.

    abstract::Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, which produce high amounts of extracellular matrix (ECM) proteins leadi...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-019-09854-6

    authors: Gorabi AM,Hajighasemi S,Kiaie N,Rosano GMC,Sathyapalan T,Al-Rasadi K,Sahebkar A

    更新日期:2020-09-01 00:00:00

  • The management of conditioned nutritional requirements in heart failure.

    abstract::Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, p...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-006-9195-3

    authors: Allard ML,Jeejeebhoy KN,Sole MJ

    更新日期:2006-03-01 00:00:00

  • Clinical characteristics, demographics and prognosis of transient left ventricular apical ballooning syndrome.

    abstract:BACKGROUND:Transient left ventricular apical ballooning syndrome also called Tako-Tsubo cardiomyopathy is defined as a syndrome consisting of stress induced apical ballooning of the left ventricle and normal coronary arteries. The majority of the published reports are case reports or case series with a small number of ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,meta分析

    doi:10.1007/s10741-005-8555-8

    authors: Donohue D,Movahed MR

    更新日期:2005-12-01 00:00:00

  • Effect of antidepressants on death in patients with heart failure: a systematic review and meta-analysis.

    abstract::Depression is associated with an increased risk of death in patients with heart failure (HF); however, the association between the use of antidepressants and HF prognoses remains controversial. Therefore, this meta-analysis aimed to evaluate the effect of antidepressants on the risk of death in HF patients. We retriev...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-019-09850-w

    authors: He W,Zhou Y,Ma J,Wei B,Fu Y

    更新日期:2020-11-01 00:00:00

  • A pathway and network review on beta-adrenoceptor signaling and beta blockers in cardiac remodeling.

    abstract::It is well established that cardiac remodeling plays a pivotal role in the development of heart failure, a leading cause of death worldwide. Meanwhile, sympathetic hyperactivity is an important factor in inducing cardiac remodeling. Therefore, an in-depth understanding of beta-adrenoceptor signaling pathways would hel...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-013-9417-4

    authors: Yang J,Liu Y,Fan X,Li Z,Cheng Y

    更新日期:2014-11-01 00:00:00

  • Erythropoietin: a future therapy for failing hearts?

    abstract::Recently, it has been suggested that erythropoietin may be useful in the treatment of cardiovascular disease, particularly heart failure. This may be by improving microvascular blood supply and ventricular function through prevention of apoptosis and angiogenesis. Promising results were seen in animals but the few, li...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-011-9288-5

    authors: Tilling L,Clapp B

    更新日期:2012-05-01 00:00:00

  • Diabetes-related cardiovascular and economic burden in patients hospitalized for heart failure in the US: a recent temporal trend analysis from the National Inpatient Sample.

    abstract::We aimed to study the cardiovascular and economic burden of diabetes mellitus (DM) in patients hospitalized for heart failure (HF) in the US and to assess the recent temporal trend. Data from the National Inpatient Sample were analyzed between 2005 and 2014. The prevalence of DM increased from 40.4 to 46.5% in patient...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-10012-6

    authors: Mekhaimar M,Dargham S,El-Shazly M,Al Suwaidi J,Jneid H,Abi Khalil C

    更新日期:2020-09-15 00:00:00

  • Biomarkers in heart failure: a clinical review.

    abstract::The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are freq...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-008-9123-9

    authors: Rocchiccioli JP,McMurray JJ,Dominiczak AF

    更新日期:2010-07-01 00:00:00

  • Defining the role of ultrafiltration therapy in acute heart failure: a systematic review and meta-analysis.

    abstract::Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10741-016-9559-2

    authors: Jain A,Agrawal N,Kazory A

    更新日期:2016-09-01 00:00:00

  • Beyond the myocardium? SGLT2 inhibitors target peripheral components of reduced oxygen flux in the diabetic patient with heart failure with preserved ejection fraction.

    abstract::Recent cardiovascular outcome trials have highlighted the propensity of the antidiabetic agents, SGLT2 inhibitors (SGLT2is or -flozin drugs), to exert positive clinical outcomes in patients with cardiovascular disease at risk for major adverse cardiovascular events (MACEs). Of interest in cardiac diabetology is the ph...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09996-y

    authors: Nashawi M,Sheikh O,Battisha A,Mir M,Chilton R

    更新日期:2020-06-24 00:00:00

  • Patient selection for mechanical circulatory support.

    abstract::Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as well, and it is therefore imperative to select patients at the p...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-012-9316-0

    authors: Gilotra NA,Russell SD

    更新日期:2013-01-01 00:00:00

  • Maintenance immunosuppression in heart transplantation: insights from network meta-analysis of various immunosuppression regimens.

    abstract::Previous studies have reported superiority of mechanistic target-of-rapamycin (mTOR) antagonists (mTA) over calcineurin inhibitors (CNI) as part of maintenance immunosuppression (IS) in mitigating cardiac allograft vasculopathy (CAV) after heart transplantation (HT). MEDLINE and EMBASE were searched through October 20...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09967-3

    authors: Ueyama H,Kuno T,Takagi H,Alvarez P,Asleh R,Briasoulis A

    更新日期:2020-05-18 00:00:00

  • Are all outcomes in chronic heart failure rated equally? An argument for a patient-centred approach to outcome assessment.

    abstract::Chronic heart failure (CHF) is a multi-dimensional and complex syndrome. Outcome measures are important for determining both the efficacy and quality of care and capturing the patient's perspective in evaluating the outcomes of health care delivery. Capturing the patient's perspective via patient-reported outcomes is ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-012-9369-0

    authors: Chang S,Newton PJ,Inglis S,Luckett T,Krum H,Macdonald P,Davidson PM

    更新日期:2014-03-01 00:00:00

  • The role of erythropoiesis stimulating agents and intravenous (IV) iron in the cardio renal anemia syndrome.

    abstract::Anemia is common in Congestive Heart Failure (CHF) and is associated with an increased mortality, morbidity and progressive renal failure. The most common causes of the anemia in CHF are (1) the associated Chronic Kidney Disease (CKD), which causes depression of erythropoietin (EPO) production in the kidney, and (2) e...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-010-9194-2

    authors: Silverberg DS

    更新日期:2011-11-01 00:00:00

  • Curcumin as a potential modulator of M1 and M2 macrophages: new insights in atherosclerosis therapy.

    abstract::Accumulation of macrophages within the artery wall is an eminent feature of atherosclerotic plaques. Macrophages are influenced by various plaque microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes, and thereby polarize into two main phenotypes called proinflammatory M1 and anti-...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-09764-z

    authors: Momtazi-Borojeni AA,Abdollahi E,Nikfar B,Chaichian S,Ekhlasi-Hundrieser M

    更新日期:2019-05-01 00:00:00

  • Stem cells in the diabetic infarcted heart.

    abstract::Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-010-9172-8

    authors: Glass CE,Singal PK,Singla DK

    更新日期:2010-11-01 00:00:00

  • Expanded algorithm for managing patients with acute decompensated heart failure.

    abstract::Heart failure is a complex disease process, the manifestation of various cardiac and noncardiac abnormalities. General treatment approaches for heart failure have remained the same over the past decades despite the advent of novel therapies and monitoring modalities. In the same vein, the readmission rates for heart f...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-9697-9

    authors: Njoroge JN,Cheema B,Ambrosy AP,Greene SJ,Collins SP,Vaduganathan M,Mebazaa A,Chioncel O,Butler J,Gheorghiade M

    更新日期:2018-07-01 00:00:00

  • Metabolic remodeling of substrate utilization during heart failure progression.

    abstract::Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human body. It is a serious disease burden worldwide affecting nearly 23 million patients. The concept that he...

    journal_title:Heart failure reviews

    pub_type: 杂志文章

    doi:10.1007/s10741-018-9713-0

    authors: Chen L,Song J,Hu S

    更新日期:2019-01-01 00:00:00

  • Chronic heart failure: a disease of the brain.

    abstract::The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are t...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-018-9747-3

    authors: Singh RB,Hristova K,Fedacko J,El-Kilany G,Cornelissen G

    更新日期:2019-03-01 00:00:00

  • Mechanistic implications of altered protein expression in rheumatic heart disease.

    abstract::Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (A...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09993-1

    authors: Lumngwena EN,Skatulla S,Blackburn JM,Ntusi NAB

    更新日期:2020-07-11 00:00:00

  • Central nervous system circuits modified in heart failure: pathophysiology and therapeutic implications.

    abstract::The pathophysiology of heart failure (HF) is characterized by an abnormal activation of neurohumoral systems, including the sympathetic nervous and the renin-angiotensin-aldosterone systems, which have long-term deleterious effects on the disease progression. Perpetuation of this neurohumoral activation is partially d...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-014-9427-x

    authors: Sousa-Pinto B,Ferreira-Pinto MJ,Santos M,Leite-Moreira AF

    更新日期:2014-11-01 00:00:00

  • Early diagnosis, clinical management, and follow-up of cardiovascular events with ponatinib.

    abstract::Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by neoplastic transformation of pluripotent cells due to a typical cytogenetic and molecular mutation known as Philadelphia (Ph) chromosome. In 2001, the introduction of the tyrosine kinasis inhibitor (TKI) imatinib as a therapeutic strategy...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09926-y

    authors: Casavecchia G,Galderisi M,Novo G,Gravina M,Santoro C,Agricola E,Capalbo S,Zicchino S,Cameli M,De Gennaro L,Righini FM,Monte I,Tocchetti CG,Brunetti ND,Cadeddu C,Mercuro G

    更新日期:2020-05-01 00:00:00

  • Effect of exercise on epicardial adipose tissue in adults: a systematic review and meta-analyses.

    abstract::According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) l...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-020-09965-5

    authors: Colonetti T,Grande AJ,Amaral MC,Colonetti L,Uggioni ML,da Rosa MI,Hernandez AV,Tse G,Liu T,Nerlekar N,Biondi-Zoccai G,Neto MG,Durães AR,Pontes-Neto O,Resende ES,Roever L

    更新日期:2020-05-16 00:00:00

  • How does the heart (not) die? The role of autophagy in cardiomyocyte homeostasis and cell death.

    abstract::Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-009-9137-y

    authors: Dhesi P,Tehrani F,Fuess J,Schwarz ER

    更新日期:2010-01-01 00:00:00

  • Systems biology and heart failure: concepts, methods, and potential research applications.

    abstract::Dramatic advances in molecular biology dominated twentieth century biomedical science and delineated the function of individual genes and molecules in exquisite detail. However, biological processes cannot be fully understood based on the properties of individual genes and molecules alone, since these elements act in ...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-009-9138-x

    authors: Adams KF

    更新日期:2010-07-01 00:00:00

  • Is there a blood pressure lowering effect of MRAs in heart failure? An overview and meta-analysis.

    abstract::Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP) lowering agents in resistant hypertension, this effect in heart failure is undetermined. In this synthesis of heart failure randomized controlled trials (RCTs), we evaluated the extent of BP lowering following...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1007/s10741-018-9689-9

    authors: Bazoukis G,Thomopoulos C,Tse G,Tsioufis C

    更新日期:2018-07-01 00:00:00

  • Anticoagulation in heart failure: current status and future direction.

    abstract::Despite therapeutic advances, patients with worsening heart failure (HF) requiring hospitalization have unacceptably high post-discharge mortality and re-admission rates soon after discharge. Evidence suggests a hypercoagulable state is present in patients with HF. Although thromboembolism as a direct consequence of H...

    journal_title:Heart failure reviews

    pub_type: 杂志文章,评审

    doi:10.1007/s10741-012-9343-x

    authors: Gheorghiade M,Vaduganathan M,Fonarow GC,Greene SJ,Greenberg BH,Liu PP,Massie BM,Mehra MR,Metra M,Zannad F,Cleland JG,van Veldhuisen DJ,Shah AN,Butler J

    更新日期:2013-11-01 00:00:00