Abstract：
:The diagnosis and management of heart failure remains challenging despite considerable clinical advances in recent decades. With greater understanding of the pathophysiology of this complex syndrome, a large number of candidate biomarkers have emerged and duly received scientific and clinical attention. These are frequently a measure of the degree of pathophysiological derangement or counter-regulatory processes occurring in heart failure and include biomarkers of neurohormonal activation, myocyte necrosis and myocardial remodelling amongst others. As such they may serve as an indicator of the presence, severity and possibly therapeutic response of the heart failure syndrome and may complement conventional clinical measurements and acumen. This may in turn lead to tangible clinical benefits and the targeting of intensified and often costly therapies to those most at risk. This article reviews and summarises the most extensively investigated biomarkers currently available, with an emphasis on clinical applicability and discusses the future evaluation of candidate biomarkers in patients with heart failure.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Rocchiccioli JP,McMurray JJ,Dominiczak AFdoi
10.1007/s10741-008-9123-9subject
Has Abstractpub_date
2010-07-01 00:00:00pages
251-73issue
4eissn
1382-4147issn
1573-7322journal_volume
15pub_type
杂志文章,评审abstract：:Recently, it has been suggested that erythropoietin may be useful in the treatment of cardiovascular disease, particularly heart failure. This may be by improving microvascular blood supply and ventricular function through prevention of apoptosis and angiogenesis. Promising results were seen in animals but the few, li...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9288-5
更新日期：2012-05-01 00:00:00
abstract：:Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9734-8
更新日期：2019-01-01 00:00:00
abstract：:Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9172-8
更新日期：2010-11-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,meta分析
doi：10.1007/s10741-005-8555-8
更新日期：2005-12-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/B:HREV.0000046367.99002.a4
更新日期：2004-04-01 00:00:00
abstract：:Despite therapeutic advances, patients with worsening heart failure (HF) requiring hospitalization have unacceptably high post-discharge mortality and re-admission rates soon after discharge. Evidence suggests a hypercoagulable state is present in patients with HF. Although thromboembolism as a direct consequence of H...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9343-x
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
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abstract：:Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9669-0
更新日期：2018-05-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
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更新日期：2020-05-13 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
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更新日期：2018-07-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9090-1
更新日期：2008-12-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
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更新日期：2011-05-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09869-z
更新日期：2020-01-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 已发布勘误
doi：10.1007/s10741-020-10000-w
更新日期：2020-09-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9131-9
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:Heart transplantation has become an acceptable treatment in pediatric patients with end-stage heart disease and complex congenital heart disease. The liberalization of recipient eligibility criteria, mainly age, along with the expansion of the donor pool has resulted in the acceptable transplantation of ol...
journal_title：Heart failure reviews
pub_type： 杂志文章
doi：10.1023/a:1011406022657
更新日期：2001-09-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-016-9551-x
更新日期：2016-05-01 00:00:00
abstract：:Dilated cardiomyopathy (DCM) is a common debilitating condition with limited therapeutic options besides heart transplantation or palliation. It is characterized by maladaptive remodeling of cardiomyocytes, extracellular collagen matrix (ECCM) and left ventricular (LV) geometry which contributes to further dysfunction...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9300-8
更新日期：2012-09-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9248-0
更新日期：2012-03-01 00:00:00
abstract：:In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the extracellular space. Proteins of the cardiomyocyte can be subdivided in 5 different categories: 1) Contractile proteins including myosin, actin, tropomyosin and the t...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/A:1009813621103
更新日期：2000-10-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09916-0
更新日期：2020-01-27 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09926-y
更新日期：2020-05-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
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更新日期：2011-11-01 00:00:00
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journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10015-3
更新日期：2020-08-15 00:00:00
abstract：:Diabetes and heart failure (HF) are both global epidemics with tremendous costs on society with increased rates of HF hospitalizations and worsened prognosis when co-existing, making it a significant "deadly duo." The evidence for pharmacological treatment of HF in patients with type 2 diabetes mellitus (T2DM) stems t...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9685-0
更新日期：2018-05-01 00:00:00
abstract：:Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-008-9081-2
更新日期：2009-03-01 00:00:00
abstract：:The aging population with hypertension and coronary artery disease is rapidly increasing worldwide and develops heart failure (HF). A wide range of pharmacotherapeutic drugs are recommended in the HF management guidelines. For the most part, these recommendations are based on the results of studies in the younger popu...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9282-y
更新日期：2012-09-01 00:00:00
abstract：:Patients suffering from congestive heart failure exhibit impaired myocardial energy production, myocyte calcium overload and increased oxidative stress. Nutritional factors known to be important for myocardial energy production, calcium homeostasis and the reduction of oxidative stress, such as thiamine, riboflavin, p...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-006-9195-3
更新日期：2006-03-01 00:00:00
abstract：:Descriptions of the pathophysiology of heart failure have gone through a substantial evolution in the last 50 years. It is now recognised that heart failure can occur in the presence and also in the absence of a reduction in left ventricular function. In the former situation, this classically has been described to lea...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9344-9
更新日期：2013-07-01 00:00:00
