Abstract:
:Heart failure (HF) is the leading cause of hospitalization in the USA. Despite advances in pharmacologic management, the incidence of HF is on the rise and survivability is persistently reduced. Sympathetic overdrive is implicated in the pathophysiology of HF, particularly HF with reduced ejection fraction (HFrEF). Tachycardia can be particularly deleterious and thus has spurred significant investigation to mitigate its effects. Various modalities including vagus nerve stimulation, baroreceptor activation therapy, spinal cord stimulation, renal sympathetic nerve denervation, left cardiac sympathetic denervation, and carotid body removal will be discussed. However, the effects of these modalities on tachycardia and its outcomes in HFrEF have not been well-studied. Further studies to characterize this are necessary in the future.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Devgun J,Jobanputra YB,Arustamyan M,Chait R,Ghumman Wdoi
10.1007/s10741-018-9680-5subject
Has Abstractpub_date
2018-07-01 00:00:00pages
507-516issue
4eissn
1382-4147issn
1573-7322pii
10.1007/s10741-018-9680-5journal_volume
23pub_type
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