Pharmacological treatment of chronic heart failure.

abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by neoplastic transformation of pluripotent cells due to a typical cytogenetic and molecular mutation known as Philadelphia (Ph) chromosome. In 2001, the introduction of the tyrosine kinasis inhibitor (TKI) imatinib as a therapeutic strategy...

journal_title：Heart failure reviews

authors： Casavecchia G,Galderisi M,Novo G,Gravina M,Santoro C,Agricola E,Capalbo S,Zicchino S,Cameli M,De Gennaro L,Righini FM,Monte I,Tocchetti CG,Brunetti ND,Cadeddu C,Mercuro G

更新日期：2020-05-01 00:00:00

abstract：:The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidenc...

journal_title：Heart failure reviews

authors： Kan H,Finkel MS

更新日期：2001-03-01 00:00:00

abstract：:Sympathetic-parasympathetic interaction plays a major role in the evolution and outcome of many cardiovascular disorders. Nonetheless, a thorough understanding of this relationship and of its potential implications for prognosis and management still escapes many cardiologists. This article reviews the background of sy...

journal_title：Heart failure reviews

authors： Schwartz PJ,De Ferrari GM

更新日期：2011-03-01 00:00:00

abstract：:It is over 4 years since the Prospective Comparison of angiotensin receptor/neprilysin inhibitor (ARNI) with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial was published in New England Journal of Medicine. The PARADIGM-HF trial was the one that contributed to the offici...

journal_title：Heart failure reviews

authors： Książczyk M,Lelonek M

更新日期：2020-05-01 00:00:00

abstract：:The heart consumes huge amounts of energy to fulfil its function as a relentless pump. A highly sophisticated system of energy generation based on flexibility of substrate use and efficient energy production, effective energy sensing and energy transfer ensures function of the healthy heart across a range of physiolog...

journal_title：Heart failure reviews

authors： Siddiqi N,Singh S,Beadle R,Dawson D,Frenneaux M

更新日期：2013-09-01 00:00:00

abstract：:Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...

journal_title：Heart failure reviews

authors： Kaplan A,Abidi E,El-Yazbi A,Eid A,Booz GW,Zouein FA

更新日期：2018-05-01 00:00:00

abstract：:Accumulation of macrophages within the artery wall is an eminent feature of atherosclerotic plaques. Macrophages are influenced by various plaque microenvironmental stimuli, such as oxidized lipids, cytokines, and senescent erythrocytes, and thereby polarize into two main phenotypes called proinflammatory M1 and anti-...

journal_title：Heart failure reviews

authors： Momtazi-Borojeni AA,Abdollahi E,Nikfar B,Chaichian S,Ekhlasi-Hundrieser M

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Whether mechanical restraint of the left ventricle (LV) can influence remodeling following myocardial infarction (MI) remains poorly understood. The following discussion details three studies examining the effects of surgically placing a cardiac support device (CSD) over the entire epicardial surface, on inf...

journal_title：Heart failure reviews

authors： Blom AS,Pilla JJ,Gorman RC 3rd,Gorman JH,Mukherjee R,Spinale FG,Acker MA

更新日期：2005-06-01 00:00:00

abstract：:Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, i...

journal_title：Heart failure reviews

authors： Danziger RS

更新日期：2008-09-01 00:00:00

abstract：:Evidence-based management has improved long-term survival in patients with heart failure (HF). However, an unintended consequence of increased longevity is that patients with HF are exposed to a greater symptom burden over time. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suf...

journal_title：Heart failure reviews

authors： Alpert CM,Smith MA,Hummel SL,Hummel EK

更新日期：2017-01-01 00:00:00

abstract：:The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...

journal_title：Heart failure reviews

authors： Calderone A

更新日期：2003-01-01 00:00:00

abstract：:Important changes occur in the cardiovascular system with advancing age, even in apparently healthy individuals. Thickening and stiffening of the large arteries develop due to collagen and calcium deposition and loss of elastic fibers in the medial layer. These arterial changes cause systolic blood pressure to rise wi...

journal_title：Heart failure reviews

authors： Fleg JL,Strait J

更新日期：2012-09-01 00:00:00

abstract：:In the United States and Europe, approximately 90% of heart failure hospitalizations are due to symptoms and signs of sodium and fluid excess. Congestion is associated with heart failure progression. Venous congestion, rather than a reduced cardiac output, may be the primary hemodynamic factor driving worsening renal ...

journal_title：Heart failure reviews

authors： Costanzo MR,Jessup M

更新日期：2012-03-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mor...

journal_title：Heart failure reviews

authors： Moustafa A,Khan MS,Alsamman MA,Jamal F,Atalay MK

更新日期：2020-05-13 00:00:00

abstract：:Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP) lowering agents in resistant hypertension, this effect in heart failure is undetermined. In this synthesis of heart failure randomized controlled trials (RCTs), we evaluated the extent of BP lowering following...

journal_title：Heart failure reviews

authors： Bazoukis G,Thomopoulos C,Tse G,Tsioufis C

更新日期：2018-07-01 00:00:00

abstract：:In the past decade, cardiac pacing devices (either permanent pacemakers or Implanted Cardioverter Defibrillators) have become increasingly common in patients with heart failure. The manner in which the device is programmed to pace the heart can have significant implications on cardiac hemodynamics, both positive and n...

journal_title：Heart failure reviews

authors： Lahiri MK,Mao JT,Schuger CD

更新日期：2011-09-01 00:00:00

abstract：:Depression is associated with an increased risk of death in patients with heart failure (HF); however, the association between the use of antidepressants and HF prognoses remains controversial. Therefore, this meta-analysis aimed to evaluate the effect of antidepressants on the risk of death in HF patients. We retriev...

journal_title：Heart failure reviews

authors： He W,Zhou Y,Ma J,Wei B,Fu Y

更新日期：2020-11-01 00:00:00

abstract：:Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...

journal_title：Heart failure reviews

authors： Dhalla NS,Rangi S,Babick AP,Zieroth S,Elimban V

更新日期：2012-09-01 00:00:00

abstract：:Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...

journal_title：Heart failure reviews

authors： Ruggeri C,Gioffré S,Achilli F,Colombo GI,D'Alessandra Y

更新日期：2018-01-01 00:00:00

abstract：:The evolving paradigm of heart failure has now been expanded to include the favorable neurohormonal, structural and hemodynamic profile of B-type natriuretic peptide [BNP]. As a marker of left ventricular dysfunction, BNP is a practical tool that facilitates diagnosis, contributes to prognostic evaluations and tracks ...

journal_title：Heart failure reviews

authors： Yancy CW

更新日期：2003-10-01 00:00:00

abstract：:Many factors contribute to the pathophysiology and progression of heart failure (HF), offering the potential for many synergistic therapeutic approaches to its management. For patients, who have systolic HF, prolonged QRS and receiving guideline-indicated pharmacological therapy, cardiac resynchronization therapy (CRT...

journal_title：Heart failure reviews

authors： Buga L

更新日期：2012-11-01 00:00:00

abstract：:Autophagy plays a critical and seemingly dual-purposed role in cardiomyocytes, being implicated as a mechanism of both cellular survival, for example, during ischemia/reperfusion injury and a mechanism of cell death at stages in which progressive myocyte alterations are beyond repair. This review aims to highlight the...

journal_title：Heart failure reviews

authors： Dhesi P,Tehrani F,Fuess J,Schwarz ER

更新日期：2010-01-01 00:00:00

abstract：:Diabetes is a key independent risk factor in the development of heart failure (HF) and a strong, adverse prognostic factor in HF patients. HF remains the primary cause of hospitalisation for diabetics and, as previous studies have shown, when HF occurs in these patients, intensive glycaemic control does not directly i...

journal_title：Heart failure reviews

authors： Dutka M,Bobiński R,Ulman-Włodarz I,Hajduga M,Bujok J,Pająk C,Ćwiertnia M

更新日期：2020-11-04 00:00:00

abstract：:It is now clear that diastolic heart failure (DHF) is an important, perhaps even dominant form of heart failure in older Americans. However, our knowledge base regarding the epidemiology, pathophysiology, natural history, and therapy of this relatively recently recognized disorder is limited. A number of normal age re...

journal_title：Heart failure reviews

authors： Kitzman DW

更新日期：2002-01-01 00:00:00

abstract：:Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...

journal_title：Heart failure reviews

authors： Palazzuoli A,Ceccarelli E,Ruocco G,Nuti R

更新日期：2018-05-01 00:00:00

abstract：:Cardiac magnetic resonance spectroscopy (MRS) is a noninvasive method to assess by-products of myocardial metabolism. Recent developments in shorter scan protocols and more powerful field strengths have created interest in utilizing this technology in studying and characterizing the metabolic derangements in heart fai...

journal_title：Heart failure reviews

authors： Qureshi WT,Nasir UB

更新日期：2017-07-01 00:00:00

abstract：:An important feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this hemodynamic deterioration are not known. We and others have advanced the hypothesis that th...

journal_title：Heart failure reviews

authors： Sabbah HN,Sharov VG,Goldstein S

更新日期：2000-06-01 00:00:00

abstract：:In response to a prolonged pressure- or volume-overload, alterations occur in myocardial fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been found to be reduced in hypertrophied hearts compared to non-hypertrophied hearts. However, this observation depends upon the degree of card...

journal_title：Heart failure reviews

authors： Sambandam N,Lopaschuk GD,Brownsey RW,Allard MF

更新日期：2002-04-01 00:00:00

abstract：:Pulmonary arterial hypertension (PAH) is a subcategory of pulmonary hypertension (PH) that comprises a group of disorders with similar pulmonary vascular pathology. Though PH is common, the estimated incidence of IPAH is 1-3 cases per million, making it a rare disease. The hemodynamic definition of PAH is a mean pulmo...

journal_title：Heart failure reviews

authors： Awdish R,Cajigas H

更新日期：2016-05-01 00:00:00

abstract：:Since its discovery in 1988, there has been increasing evidence that endothelin-1 (ET-1) plays an important role in the pathophysiology of hypertension and its related end-organ damages. First studies, using ET-1 administration in animals or in humans suspected this role by demonstrating the hypertensive properties of...

journal_title：Heart failure reviews

authors： Donckier JE

更新日期：2001-12-01 00:00:00