Abstract:
:An important feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this hemodynamic deterioration are not known. We and others have advanced the hypothesis that this hemodynamic deterioration results from progressive intrinsic contractile dysfunction of viable cardiomyocytes and/or from ongoing loss of cardiomyocytes. This review will focus on the concept of ongoing cardiac myocyte loss as a contributing factor to the progression of left ventricular dysfunction that characterizes the heart failure state. Specifically, the discussion will center on apoptosis or "programmed cell death" as a potential mediator of cardiomyocyte loss. In recent years, several studies have shown that constituent myocytes of failed explanted human hearts and hearts of animals with experimentally induced heart failure undergo apoptosis. Studies have also shown that cardiomyocyte apoptosis occurs following acute myocardial infarction, in the hypertrophied heart as well as in the aging heart; conditions frequently associated with the development of failure. While available data support the existence of myocyte apoptosis in the failing heart, lacking are studies which address the importance of myocyte apoptosis in the progression of LV dysfunction. As part of this discussion, we will address this issue and construct a case in support of a concept that the failing myocardium is subject to regional hypoxia, an abnormality that can potentially trigger cardiomyocyte apoptosis. If loss of cardiac myocytes through apoptosis can be shown to be an important contributor to the progression of heart failure, and if exact physiologic and molecular factors that trigger apoptosis in the heart can be identified, the stage will be set for the development of novel therapeutic modalities aimed at preventing, or at the very least retarding, the process of progressive ventricular dysfunction and the ultimate transition toward end-stage, intractable heart failure.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Sabbah HN,Sharov VG,Goldstein Sdoi
10.1023/A:1009880720032subject
Has Abstractpub_date
2000-06-01 00:00:00pages
131-8issue
2eissn
1382-4147issn
1573-7322journal_volume
5pub_type
杂志文章abstract::Anemia is common in Congestive Heart Failure (CHF) and is associated with an increased mortality, morbidity and progressive renal failure. The most common causes of the anemia in CHF are (1) the associated Chronic Kidney Disease (CKD), which causes depression of erythropoietin (EPO) production in the kidney, and (2) e...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-010-9194-2
更新日期:2011-11-01 00:00:00
abstract:INTRODUCTION:Heart transplantation has become an acceptable treatment in pediatric patients with end-stage heart disease and complex congenital heart disease. The liberalization of recipient eligibility criteria, mainly age, along with the expansion of the donor pool has resulted in the acceptable transplantation of ol...
journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1023/a:1011406022657
更新日期:2001-09-01 00:00:00
abstract::Evidence-based management has improved long-term survival in patients with heart failure (HF). However, an unintended consequence of increased longevity is that patients with HF are exposed to a greater symptom burden over time. In addition to classic symptoms such as dyspnea and edema, patients with HF frequently suf...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9581-4
更新日期:2017-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10014-4
更新日期:2020-08-29 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09996-y
更新日期:2020-06-24 00:00:00
abstract::Congestive heart failure is most often caused by scar from coronary occlusion. The transition from occluded vessel to scar to dilation results in a remodeled ventricle that changes shape from ellipse to sphere. This shape change following an index event is called remodeling and a surgical approach for restoration (bri...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-6801-8
更新日期:2004-10-01 00:00:00
abstract::Heart failure (HF) is a chronic, systemic disorder that presents a serious and growing public health problem due to its high prevalence, mortality, and cost of care. Due to the aging of the population and medical advances that prolong the life of HF patients, more effective, widespread strategies for improved HF manag...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09781-6
更新日期:2019-07-01 00:00:00
abstract::Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 i...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-010-9170-x
更新日期:2011-01-01 00:00:00
abstract::According to previous epidemiological studies, we can reduce the thickness of epicardial fat and improve cardiovascular risk factors through exercise, and the changes may depend on the form of exercise. We systemically reviewed published studies that evaluated exercise intervention on epicardial adipose tissue (EAT) l...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09965-5
更新日期:2020-05-16 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1026182912461
更新日期:2003-10-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1024705214292
更新日期:2003-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s10741-013-9407-6
更新日期:2014-09-01 00:00:00
abstract::Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they al...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9646-z
更新日期:2017-11-01 00:00:00
abstract::The abnormal regulation of nitric oxide synthase activity represents an underlying feature of heart failure. Increased peripheral vascular resistance, and decreased renal function may be in part related to impaired endothelium-dependent nitric oxide (NO) synthesis. Paradoxically, the chronic production of NO by induci...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1022147005110
更新日期:2003-01-01 00:00:00
abstract::The pathophysiology of heart failure (HF) is characterized by an abnormal activation of neurohumoral systems, including the sympathetic nervous and the renin-angiotensin-aldosterone systems, which have long-term deleterious effects on the disease progression. Perpetuation of this neurohumoral activation is partially d...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-014-9427-x
更新日期:2014-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1020714518246
更新日期:2002-10-01 00:00:00
abstract::Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (A...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09993-1
更新日期:2020-07-11 00:00:00
abstract::Treatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline ...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10004-6
更新日期:2021-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1026107701983
更新日期:2003-10-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2019-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1007/s10741-018-9713-0
更新日期:2019-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09825-x
更新日期:2020-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9324-0
更新日期:2013-01-01 00:00:00
abstract::Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as well, and it is therefore imperative to select patients at the p...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9316-0
更新日期:2013-01-01 00:00:00
abstract::We aimed to study the cardiovascular and economic burden of diabetes mellitus (DM) in patients hospitalized for heart failure (HF) in the US and to assess the recent temporal trend. Data from the National Inpatient Sample were analyzed between 2005 and 2014. The prevalence of DM increased from 40.4 to 46.5% in patient...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10012-6
更新日期:2020-09-15 00:00:00
abstract::End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9298-y
更新日期:2012-09-01 00:00:00
abstract::Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive, life-threatening disease characterized by deposition of insoluble amyloid fibrils in the myocardium, resulting in cardiac structural and functional abnormalities and ultimately heart failure. Disease frequency is reportedly lower in women than men, but s...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10010-8
更新日期:2021-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9359-2
更新日期:2013-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9061-y
更新日期:2008-09-01 00:00:00
abstract::Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9353-8
更新日期:2013-09-01 00:00:00