Abstract:
:From previous systematic reviews and meta-analyses, there is consensus about the positive effect of exercise training on exercise capacity for systolic heart failure (HF); however, the effect on actual prognostic markers such as NTproBNP and minute ventilation/carbon dioxide production (VE/VCO2) slope has not been evaluated. The primary aim of the proposed study is to determine the effect of aerobic exercise training (AEX) on the VE/VCO2 slope and NTproBNP. The following databases (up to February 30, 2013) were searched with no language limitations: CENTRAL (The Cochrane Library 2013, issue 2), MEDLINE (from January 1966), EMBASE (from January 1980), and Physiotherapy Evidence Database (PEDro) (from January 1929). We screened reference lists of articles and also conducted an extensive hand search of the literature. Randomized controlled trials of exercise-based interventions with 2-month follow-up or longer compared to usual medical care or placebo were included. The study population comprised adults aged between 18 and 65 years, with evidence of chronic systolic heart failure (LVEF < 45 % and baseline NTproBNP > 300 pg/ml). Two review authors independently extracted data on study design, participants, interventions, and outcomes. We assessed the risk of bias using PEDro scale. We calculated mean differences (MD) or standardized mean differences between intervention and control groups for outcomes with sufficient data; for other outcomes, we described findings from individual studies. Eight studies involving a total of 408 participants met the inclusion criteria across the NTproBNP (5 studies with 191 patients) and VE/VCO2 slope (4 studies with 217 patients). Aerobic exercise significantly improved NTproBNP by a MD of -817.75 [95 % confidence interval (CI) -929.31 to -706.19]. Mean differences across VE/VCO2 slope were -6.55 (95 % CI -7.24 to -5.87). Those patients' characteristics and exercise were similar (frequency = 3-5 times/week; duration = 20-50 min/day; intensity = 60-80 % of VO2 peak) on the included studies. Moreover, the risk of bias across all studies was homogeneous (PEDro scale = 7-8 points). However, based on the statistical analysis, the heterogeneity among the studies was still high, which is related to the variable characteristics of the studies. Aerobic exercise may be effective at improving NTproBNP and the VE/VCO2 slope in systolic HF patients, but these effects are limited to a specific HF population meeting specific inclusion criterion in a limited number of studies. Future randomized controlled studies including diastolic and HF overleap with pulmonary diseases are needed to better understand the exact influence of AEX.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Cipriano G Jr,Cipriano VT,da Silva VZ,Cipriano GF,Chiappa GR,de Lima AC,Cahalin LP,Arena Rdoi
10.1007/s10741-013-9407-6subject
Has Abstractpub_date
2014-09-01 00:00:00pages
655-67issue
5eissn
1382-4147issn
1573-7322journal_volume
19pub_type
杂志文章,meta分析,评审abstract::The sympathetic nervous system provides the most powerful stimulation of cardiac function, brought about via norepinephrine and epinephrine and their postsynaptic beta-adrenergic receptors. More than 30 years after the first use of practolol in patients with heart failure beta blockers are now the mainstay of the phar...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9132-8
更新日期:2009-12-01 00:00:00
abstract::Multiple in vitro and in vivo studies showed that the signal transducer and activator of transcription 3 (STAT3) protein is involved in cardiomyocyte protection and hypertrophy and via paracrine pathways impacts on the non-myocyte compartment, i.e., the vasculature and the extracellular matrix. In this regard, STAT3 i...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-010-9170-x
更新日期:2011-01-01 00:00:00
abstract::Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-015-9475-x
更新日期:2015-07-01 00:00:00
abstract::Many factors contribute to the pathophysiology and progression of heart failure (HF), offering the potential for many synergistic therapeutic approaches to its management. For patients, who have systolic HF, prolonged QRS and receiving guideline-indicated pharmacological therapy, cardiac resynchronization therapy (CRT...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9351-x
更新日期:2012-11-01 00:00:00
abstract::An important feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this hemodynamic deterioration are not known. We and others have advanced the hypothesis that th...
journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1023/A:1009880720032
更新日期:2000-06-01 00:00:00
abstract::Beta-blockers are not an homogeneous group of agents. Only three beta-blockers, carvedilol, bisoprolol and metoprolol succinate, have had favorable effects on prognosis in controlled clinical trials in the patients with chronic heart failure. However, pharmacological differences exist between them. Metoprolol and biso...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/B:HREV.0000046367.99002.a4
更新日期:2004-04-01 00:00:00
abstract::In addition to functional alterations, heart failure has a structural basis as well. This concerns all components of the cardiac myocytes as well as the extracellular space. Proteins of the cardiomyocyte can be subdivided in 5 different categories: 1) Contractile proteins including myosin, actin, tropomyosin and the t...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/A:1009813621103
更新日期:2000-10-01 00:00:00
abstract::Diabetes is a global epidemic and a leading cause of death with more than 422 million patients worldwide out of whom around 392 million alone suffer from type 2 diabetes (T2D). Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel and effective drugs in managing glycemia of T2D patients. These inhibitors gained...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9665-9
更新日期:2018-05-01 00:00:00
abstract::Heart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mor...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09958-4
更新日期:2020-05-13 00:00:00
abstract::Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9112-z
更新日期:2009-09-01 00:00:00
abstract::It is now clear that diastolic heart failure (DHF) is an important, perhaps even dominant form of heart failure in older Americans. However, our knowledge base regarding the epidemiology, pathophysiology, natural history, and therapy of this relatively recently recognized disorder is limited. A number of normal age re...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1013745705318
更新日期:2002-01-01 00:00:00
abstract::Heart failure with preserved ejection fraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertiona...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09787-0
更新日期:2019-09-01 00:00:00
abstract::Heart failure (HF) is a common complication in patients with type 2 diabetes and it is closely associated with high morbidity and mortality rate. The incidence of cardiovascular events in patients with diabetes is related to high levels of glycemia, expressed by increase of HbA1c levels. However, there is little evide...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9669-0
更新日期:2018-05-01 00:00:00
abstract::Myocarditis (MCD) is a type of inflammatory disease in which inflammatory cells infiltrate the myocardium, leading to cardiac dysfunction, myocardial necrosis, and fibrosis. Although it has been reported that MCD is mediated by T cells, the immune system is complex and includes many types of immune cells that interact...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09799-w
更新日期:2019-11-01 00:00:00
abstract::Acute heart failure syndromes (AHFS) are associated with the rapid onset of heart failure (HF) signs and symptoms. Hospitalizations for AHFS continue to rise and are associated with significant mortality and morbidity. Several pharmacological agents are currently approved for the treatment of AHFS, but their use is as...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-009-9136-z
更新日期:2009-12-01 00:00:00
abstract::Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-011-9278-7
更新日期:2012-09-01 00:00:00
abstract::Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, i...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9061-y
更新日期:2008-09-01 00:00:00
abstract::End-stage systolic heart failure is an increasingly common problem in elderly patients and is associated with high cost, poor quality of life, and poor outcomes. Mechanical circulatory support is a promising therapy as both a bridge to transplantation and destination therapy. Elderly patients are frequently ineligible...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9298-y
更新日期:2012-09-01 00:00:00
abstract::Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The ma...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-006-9482-z
更新日期:2006-06-01 00:00:00
abstract::Treatment of patients with heart failure with reduced ejection fraction (HFrEF) with currently available therapies reduces morbidity and mortality. However, implementation of these therapies is a problem with only few patients achieving guideline-recommended maximal doses of therapy. In an effort to improve guideline ...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10004-6
更新日期:2021-01-01 00:00:00
abstract::Sympathetic-parasympathetic interaction plays a major role in the evolution and outcome of many cardiovascular disorders. Nonetheless, a thorough understanding of this relationship and of its potential implications for prognosis and management still escapes many cardiologists. This article reviews the background of sy...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-010-9179-1
更新日期:2011-03-01 00:00:00
abstract::Ischemic heart disease (IHD) remains the single most common cause of death worldwide. Ischemic cardiomyopathy is a major sequel of coronary artery disease. The economic health burden of IHD is substantial. In patients with old myocardial infarction (OMI), the extent of viable myocardium (VM) directly affects the short...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9626-3
更新日期:2017-07-01 00:00:00
abstract:BACKGROUND:Whether mechanical restraint of the left ventricle (LV) can influence remodeling following myocardial infarction (MI) remains poorly understood. The following discussion details three studies examining the effects of surgically placing a cardiac support device (CSD) over the entire epicardial surface, on inf...
journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1007/s10741-005-4640-2
更新日期:2005-06-01 00:00:00
abstract::To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the f...
journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1007/s10741-017-9656-x
更新日期:2018-01-01 00:00:00
abstract::Cardiac magnetic resonance spectroscopy (MRS) is a noninvasive method to assess by-products of myocardial metabolism. Recent developments in shorter scan protocols and more powerful field strengths have created interest in utilizing this technology in studying and characterizing the metabolic derangements in heart fai...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9611-x
更新日期:2017-07-01 00:00:00
abstract::Pulmonary hypertension that develops in the setting of underlying lung diseases such as COPD or idiopathic pulmonary fibrosis (IPF) is associated with decreased functional status, worsening hypoxemia and quality of life, and increased mortality. This complication of lung disease is complex in its origin and carries a ...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9551-x
更新日期:2016-05-01 00:00:00
abstract::Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-010-9172-8
更新日期:2010-11-01 00:00:00
abstract::Healing after myocardial infarction (MI) is a well-orchestrated time-dependent process that involves inflammation, tissue repair with extracellular collagen matrix (ECCM) deposition and scar formation, and remodeling of myocardial structure, matrix, vasculature, and function. Rapid early ECCM degradation followed by s...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9090-1
更新日期:2008-12-01 00:00:00
abstract::Dilated cardiomyopathy (DCM) represents one of the primary cardiomyopathies and may lead to heart failure and sudden death. Until recently, ventricular arrhythmias were considered to be a direct consequence of the systolic dysfunction of the left ventricle (LV) and guidelines for implantable cardioverter defibrillator...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09933-z
更新日期:2020-02-13 00:00:00
abstract::B-Type natriuretic peptide (BNP) is elevated in states of increased ventricular wall stress. BNP is most commonly used to rule out congestive heart failure (CHF) in dyspneic patients. BNP levels are influenced by age, gender and, to a surprisingly large extent, by body mass index (BMI). In addition, it can be elevated...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9002-9
更新日期:2007-03-01 00:00:00