Abstract:
:To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the full-text articles was performed using the Quality in Prognosis Studies tool. We included 28 studies. Eleven studies used the medication possession ratio, 15 the proportion of days covered, and six studies used own methods to calculate medication adherence. Almost all studies used an observation period of 1 year. Twenty-one studies considered angiotensin converting enzyme inhibitors or angiotensin receptor antagonists, 17 beta-blockers, 11 diuretics, eight mineralocorticoid receptor antagonists, six digitalis-glycosides, and six statins. Eight studies looked at single substance classes; 18 studies analyzed more than one drug class. Different assumptions for the dosage were used. In seven studies, switching within therapeutic classes was allowed. Three studies allowed stockpiling, nine studies censored hospital stays, and four studies censored death. Seventeen studies dichotomized the results, applying the cutoff ≥ 0.8 to define a patient as adherent. Eight studies analyzed adherence as a continuous value. The reporting quality of the methodology applied varied widely between studies. A gold standard is currently not available for the quantification of medication adherence in patients with chronic heart failure via claims data. To assess the methodology, the following parameters should be described: method of measurements, observation period, substances, dosing, switches, stockpiling, truncations, statistical analysis, and cutoff for adherence.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Krueger K,Griese-Mammen N,Schubert I,Kieble M,Botermann L,Laufs U,Kloft C,Schulz Mdoi
10.1007/s10741-017-9656-xsubject
Has Abstractpub_date
2018-01-01 00:00:00pages
63-71issue
1eissn
1382-4147issn
1573-7322pii
10.1007/s10741-017-9656-xjournal_volume
23pub_type
杂志文章abstract::Cell transplantation is emerging as a new treatment designed tot improve the poor outcome of patients with cardiac failure. Its rationale is that implantation of contractile cells into postinfarction scars can functionally rejuvenate these areas. Primarily for practical reasons, autologous skeletal myoblasts have been...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1024705214292
更新日期:2003-07-01 00:00:00
abstract::Heart failure continues to be associated with high morbidity and mortality. Over the past decade, left ventricular assist devices have been shown to improve the survival and quality of life. However, it is quite clear that very sick patients do not do as well, and it is therefore imperative to select patients at the p...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9316-0
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09799-w
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9528-9
更新日期:2016-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9576-1
更新日期:2016-11-01 00:00:00
abstract::Depression is associated with an increased risk of death in patients with heart failure (HF); however, the association between the use of antidepressants and HF prognoses remains controversial. Therefore, this meta-analysis aimed to evaluate the effect of antidepressants on the risk of death in HF patients. We retriev...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2020-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9611-x
更新日期:2017-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9697-9
更新日期:2018-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9037-y
更新日期:2007-12-01 00:00:00
abstract::Rheumatic heart disease (RHD) is a major cause of cardiovascular morbidity and mortality in low- and middle-income countries, where living conditions promote spread of group A β-haemolytic streptococcus. Autoimmune reactions due to molecular mimicry of bacterial epitopes by host proteins cause acute rheumatic fever (A...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09993-1
更新日期:2020-07-11 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9031-4
更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1020714518246
更新日期:2002-10-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-5247-3
更新日期:2005-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09787-0
更新日期:2019-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-011-9288-5
更新日期:2012-05-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9551-x
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pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-009-9137-y
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journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1007/s10741-018-9713-0
更新日期:2019-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 已发布勘误
doi:10.1007/s10741-020-10000-w
更新日期:2020-09-01 00:00:00