Abstract:
:Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human body. It is a serious disease burden worldwide affecting nearly 23 million patients. The concept that heart failure is "an engine out of fuel" has been generally accepted and metabolic remodeling has been recognized as an important aspect of this condition; it is characterized by defects in energy production and changes in metabolic pathways involved in the regulation of essential cellular functions such as the process of substrate utilization, the tricarboxylic acid cycle, oxidative phosphorylation, and high-energy phosphate metabolism. Advances in second-generation sequencing, proteomics, and metabolomics have made it possible to perform comprehensive tests on genes and metabolites that are crucial in the process of HF, thereby providing a clearer and comprehensive understanding of metabolic remodeling during HF. In recent years, new metabolic changes such as ketone bodies and branched-chain amino acids were demonstrated as alternative substrates in end-stage HF. This systematic review focuses on changes in metabolic substrate utilization during the progression of HF and the underlying regulatory mechanisms. Accordingly, the conventional concepts of metabolic remodeling characteristics are reviewed, and the latest developments, particularly multi-omics studies, are compiled.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Chen L,Song J,Hu Sdoi
10.1007/s10741-018-9713-0subject
Has Abstractpub_date
2019-01-01 00:00:00pages
143-154issue
1eissn
1382-4147issn
1573-7322pii
10.1007/s10741-018-9713-0journal_volume
24pub_type
杂志文章abstract::Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its morbidity and mortality. Cardiac fibroblast is the keystone of fibrogenesis, being activated by numerous cellular and humoral factors. Macrophages, CD4+ and CD8+ T cells, mast cells, and endothelial cells stimulate fibrogenesis dir...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09940-0
更新日期:2020-03-13 00:00:00
abstract::Despite therapeutic advances, patients with worsening heart failure (HF) requiring hospitalization have unacceptably high post-discharge mortality and re-admission rates soon after discharge. Evidence suggests a hypercoagulable state is present in patients with HF. Although thromboembolism as a direct consequence of H...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9343-x
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09879-x
更新日期:2020-05-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-015-9475-x
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-014-9427-x
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journal_title:Heart failure reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2018-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-011-9239-1
更新日期:2011-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-10022-4
更新日期:2020-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9697-9
更新日期:2018-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9626-3
更新日期:2017-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09995-z
更新日期:2020-06-21 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-006-9482-z
更新日期:2006-06-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9528-9
更新日期:2016-11-01 00:00:00
abstract::Heart failure (HF) is a chronic, systemic disorder that presents a serious and growing public health problem due to its high prevalence, mortality, and cost of care. Due to the aging of the population and medical advances that prolong the life of HF patients, more effective, widespread strategies for improved HF manag...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09781-6
更新日期:2019-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09799-w
更新日期:2019-11-01 00:00:00
abstract::Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, which produce high amounts of extracellular matrix (ECM) proteins leadi...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09854-6
更新日期:2020-09-01 00:00:00
abstract::This review evaluates the hypothesis that the cardiac effects of amiodarone can be explained-at least partly-by the induction of a local 'hypothyroid-like condition' in the heart. Evidence supporting the hypothesis comprises the observation that amiodarone exerts an inhibitory effect on the binding of T3 to thyroid ho...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9131-9
更新日期:2010-03-01 00:00:00
abstract::Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2010-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9663-y
更新日期:2018-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-019-09869-z
更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09967-3
更新日期:2020-05-18 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09926-y
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abstract::The spectrum of ischemic heart diseases, encompassing acute myocardial infarction to heart failure, represents the leading cause of death worldwide. Although extensive progress in cardiovascular diagnoses and therapy has been made, the prevalence of the disease continues to increase. Cardiac regeneration has a promisi...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-020-09953-9
更新日期:2020-04-18 00:00:00
abstract::Cardiopulmonary exercise testing (CPET) is a procedure widely used in daily clinical activity to investigate cardiac and pulmonary disorders. Peak oxygen consumption (VO2 peak) is the most validated and clinically accepted parameter used to report aerobic capacity in healthy individuals and in different clinical setti...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-013-9403-x
更新日期:2014-09-01 00:00:00
abstract::Physiologic endurance exercise performance is primarily limited by cardiac function. In patients with heart failure, there is dissociation between cardiac performance and exercise capacity, suggesting a distinct role of abnormal peripheral organ function, including skeletal muscle function. The impact of heart failure...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-012-9353-8
更新日期:2013-09-01 00:00:00
abstract::Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate ...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-018-9734-8
更新日期:2019-01-01 00:00:00
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journal_title:Heart failure reviews
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-016-9551-x
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abstract::Genomic mechanisms of mineralocorticoid action have been increasingly elucidated over the past four decades. In renal epithelia, the main effect is an increase in sodium transport through activation and de novo synthesis of epithelial sodium channels. This leads to increased concentrations of intracellular sodium acti...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-005-2347-z
更新日期:2005-01-01 00:00:00