Non-ischemic dilated cardiomyopathy and cardiac fibrosis.

abstract：:There is ongoing controversy regarding the association between loop diuretics (LD), especially in high doses, and adverse clinical outcomes in outpatients with heart failure (HF). We performed a systematic review of the evidence for LD in outpatients with HF. We searched MEDLINE, EMBASE, and Cochrane Clinical Trial Co...

journal_title：Heart failure reviews

authors： Kapelios CJ,Bonou Μ,Malliaras K,Athanasiadi E,Vakrou S,Skouloudi M,Masoura C,Barbetseas J

更新日期：2020-06-21 00:00:00

abstract：:Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the str...

journal_title：Heart failure reviews

authors： Axell RG,Hoole SP,Hampton-Till J,White PA

更新日期：2015-05-01 00:00:00

abstract：:It is over 4 years since the Prospective Comparison of angiotensin receptor/neprilysin inhibitor (ARNI) with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) trial was published in New England Journal of Medicine. The PARADIGM-HF trial was the one that contributed to the offici...

journal_title：Heart failure reviews

authors： Książczyk M,Lelonek M

更新日期：2020-05-01 00:00:00

abstract：:It is now clear that diastolic heart failure (DHF) is an important, perhaps even dominant form of heart failure in older Americans. However, our knowledge base regarding the epidemiology, pathophysiology, natural history, and therapy of this relatively recently recognized disorder is limited. A number of normal age re...

journal_title：Heart failure reviews

authors： Kitzman DW

更新日期：2002-01-01 00:00:00

abstract：:The discovery of cardiac natriuretic peptides two decades ago has lead to considerable research to investigate their biochemical and physiological properties. Clearly the heart is not just a pump but is also an endocrine organ that together with the kidneys control volume overload. The natriuretic peptides are a group...

journal_title：Heart failure reviews

authors： Azzazy HM,Christenson RH

更新日期：2003-10-01 00:00:00

abstract：:Cardiac fibrosis stems from the changes in the expression of fibrotic genes in cardiac fibroblasts (CFs) in response to the tissue damage induced by various cardiovascular diseases (CVDs) leading to their transformation into active myofibroblasts, which produce high amounts of extracellular matrix (ECM) proteins leadi...

journal_title：Heart failure reviews

authors： Gorabi AM,Hajighasemi S,Kiaie N,Rosano GMC,Sathyapalan T,Al-Rasadi K,Sahebkar A

更新日期：2020-09-01 00:00:00

abstract：:Despite therapeutic advances, patients with worsening heart failure (HF) requiring hospitalization have unacceptably high post-discharge mortality and re-admission rates soon after discharge. Evidence suggests a hypercoagulable state is present in patients with HF. Although thromboembolism as a direct consequence of H...

journal_title：Heart failure reviews

authors： Gheorghiade M,Vaduganathan M,Fonarow GC,Greene SJ,Greenberg BH,Liu PP,Massie BM,Mehra MR,Metra M,Zannad F,Cleland JG,van Veldhuisen DJ,Shah AN,Butler J

更新日期：2013-11-01 00:00:00

abstract：:Cardiac hypertrophy (CH) is generally considered adaptive responses that may occur after myocardial infarction, pressure overload, volume overload, inflammatory heart muscle disease, or idiopathic dilated cardiomyopathy, whereas long-term stimulation eventually leads to heart failure (HF). However, the current molecul...

journal_title：Heart failure reviews

authors： Sun J,Wang C

更新日期：2020-11-01 00:00:00

abstract：:Obstructive sleep apnea (OSA) is increasingly recognized as a novel cardiovascular risk factor. OSA is implicated in the pathogenesis of hypertension, left ventricular dysfunction, coronary artery disease and stroke. OSA exerts its negative cardiovascular consequences through its unique pattern of intermittent hypoxia...

journal_title：Heart failure reviews

authors： Khayat R,Patt B,Hayes D Jr

更新日期：2009-09-01 00:00:00

abstract：:Apelin is an endogenous peptide acting on the APJ receptor. It consists of several isoforms characterized by different numbers of amino acids. The number of amino acids in the active isoforms range from 36 to 12. Apelin-13 and, to a lesser extent, apelin-36 are considered the most active isoforms with the greatest act...

journal_title：Heart failure reviews

authors： Folino A,Montarolo PG,Samaja M,Rastaldo R

更新日期：2015-07-01 00:00:00

abstract：:Brief ischemia to the myocardium initiates a cascade of biochemical events in cardiac myocytes that protects the heart muscle during subsequent ischemic insults. This phenomenon is called ischemic preconditioning. If an acute myocardial infarction is preceded by preinfarction angina, it results in smaller infarction s...

journal_title：Heart failure reviews

authors： Rezkalla SH,Kloner RA

更新日期：2007-12-01 00:00:00

abstract：:Nitric oxide degradation linked to endothelial dysfunction plays a central role in cardiovascular diseases. Superoxide producing enzymes such as NADPH oxidase and xanthine oxidase are responsible for NO degradation as they generate a variety of reactive oxygen species (ROS). Moreover, superoxide is rapidly degraded by...

journal_title：Heart failure reviews

authors： de Gasparo M

更新日期：2002-10-01 00:00:00

abstract：:There are multiple intrinsic mechanisms for diastolic dysfunction ranging from molecular to structural derangements in ventricular myocardium. The molecular mechanisms regulating the progression from normal diastolic function to severe dysfunction still remain poorly understood. Recent studies suggest a potentially im...

journal_title：Heart failure reviews

authors： Mikhailov AT,Torrado M

更新日期：2016-11-01 00:00:00

abstract：:We aimed to study the cardiovascular and economic burden of diabetes mellitus (DM) in patients hospitalized for heart failure (HF) in the US and to assess the recent temporal trend. Data from the National Inpatient Sample were analyzed between 2005 and 2014. The prevalence of DM increased from 40.4 to 46.5% in patient...

journal_title：Heart failure reviews

authors： Mekhaimar M,Dargham S,El-Shazly M,Al Suwaidi J,Jneid H,Abi Khalil C

更新日期：2020-09-15 00:00:00

abstract：:Since its discovery in 1988, there has been increasing evidence that endothelin-1 (ET-1) plays an important role in the pathophysiology of hypertension and its related end-organ damages. First studies, using ET-1 administration in animals or in humans suspected this role by demonstrating the hypertensive properties of...

journal_title：Heart failure reviews

authors： Donckier JE

更新日期：2001-12-01 00:00:00

abstract：:Patients diagnosed with CHF have disproportionately high rates of depression. Research has demonstrated significant consequences of depression in patients with CHF including poor quality of life, worse medical adherence and increased health complications, health care utilization, and medical costs. Despite these conse...

journal_title：Heart failure reviews

authors： O'Hea E,Houseman J,Bedek K,Sposato R

更新日期：2009-03-01 00:00:00

abstract：:The evolving paradigm of heart failure has now been expanded to include the favorable neurohormonal, structural and hemodynamic profile of B-type natriuretic peptide [BNP]. As a marker of left ventricular dysfunction, BNP is a practical tool that facilitates diagnosis, contributes to prognostic evaluations and tracks ...

journal_title：Heart failure reviews

authors： Yancy CW

更新日期：2003-10-01 00:00:00

abstract：:Magnetic resonance spectroscopy (MRS) is the only non-invasive, non-radiation-based technique for investigating the metabolism of living tissue. MRS of protons (1H-MRS), which provides the highest sensitivity of all MR-visible nuclei, is a method capable of detecting and quantifying specific cardiac biomolecules, such...

journal_title：Heart failure reviews

authors： Faller KM,Lygate CA,Neubauer S,Schneider JE

更新日期：2013-09-01 00:00:00

abstract：:Stem cell therapy is a promising approach to the treatment of ischemic heart disease via replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials have indicated that cardiac function improved consistently, but very modestly after cell-based therapy. This mainly attributed to low...

journal_title：Heart failure reviews

authors： Huang P,Tian X,Li Q,Yang Y

更新日期：2016-11-01 00:00:00

abstract：:Heart failure (HF) is a clinical syndrome caused by a decline in cardiac systolic or diastolic function, which leaves the heart unable to pump enough blood to meet the normal physiological requirements of the human body. It is a serious disease burden worldwide affecting nearly 23 million patients. The concept that he...

journal_title：Heart failure reviews

authors： Chen L,Song J,Hu S

更新日期：2019-01-01 00:00:00

abstract：:This collection of papers covers developments in a rapidly growing area, sarcomeric proteins in hypertrophied and failing myocardium. Advances in our understanding of the biochemistry and biophysics of crossbridge cycling, contributions of thick versus thin filament and the emerging role of titin, the importance and m...

journal_title：Heart failure reviews

authors： LeWinter MM,VanBuren P

更新日期：2005-09-01 00:00:00

abstract：:Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. Accumulated data from animal models of systemic ID suggest that ID is associated with several functional and structural abnormalities of the heart. However, the exact ro...

journal_title：Heart failure reviews

authors： Kobak KA,Radwańska M,Dzięgała M,Kasztura M,Josiak K,Banasiak W,Ponikowski P,Jankowska EA

更新日期：2019-03-01 00:00:00

abstract：:An important feature of heart failure is the progressive deterioration of left ventricular function that occurs in the absence of clinically apparent intercurrent adverse events. The mechanism or mechanisms responsible for this hemodynamic deterioration are not known. We and others have advanced the hypothesis that th...

journal_title：Heart failure reviews

authors： Sabbah HN,Sharov VG,Goldstein S

更新日期：2000-06-01 00:00:00

abstract：INTRODUCTION:Heart transplantation has become an acceptable treatment in pediatric patients with end-stage heart disease and complex congenital heart disease. The liberalization of recipient eligibility criteria, mainly age, along with the expansion of the donor pool has resulted in the acceptable transplantation of ol...

journal_title：Heart failure reviews

authors： Laks H,Marelli D,Odim J,Fazio D

更新日期：2001-09-01 00:00:00

abstract：:Important changes occur in the cardiovascular system with advancing age, even in apparently healthy individuals. Thickening and stiffening of the large arteries develop due to collagen and calcium deposition and loss of elastic fibers in the medial layer. These arterial changes cause systolic blood pressure to rise wi...

journal_title：Heart failure reviews

authors： Fleg JL,Strait J

更新日期：2012-09-01 00:00:00

abstract：:Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The ma...

journal_title：Heart failure reviews

authors： Adorisio R,De Luca L,Rossi J,Gheorghiade M

更新日期：2006-06-01 00:00:00

abstract：:Although several risk factors including hypertension, cardiac hypertrophy, coronary artery disease, and diabetes are known to result in heart failure, elderly subjects are more susceptible to myocardial infarction and more likely to develop heart failure. This article is intended to discuss that cardiac dysfunction in...

journal_title：Heart failure reviews

authors： Dhalla NS,Rangi S,Babick AP,Zieroth S,Elimban V

更新日期：2012-09-01 00:00:00

abstract：:Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...

journal_title：Heart failure reviews

authors： Parissis JT,Farmakis D,Nieminen M

更新日期：2007-06-01 00:00:00

abstract：:The underlying mechanism for clinical and biochemical manifestations of chronic heart failure (HF) may be due in part to neurohumoral adaptations, such as activation of the renin-angiotensin-aldosterone and sympathetic nervous systems in the periphery and the brain. Internet search and discussion with colleagues are t...

journal_title：Heart failure reviews

authors： Singh RB,Hristova K,Fedacko J,El-Kilany G,Cornelissen G

更新日期：2019-03-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) is a common disorder generating high mortality and important morbidity prevalence, with a very limited medical treatment available. Studies have shown that the pathophysiological hallmark of this condition is an elevated left intra-atrial pressure (LAP), exertiona...

journal_title：Heart failure reviews

authors： Burlacu A,Simion P,Nistor I,Covic A,Tinica G

更新日期：2019-09-01 00:00:00