Abstract:
:The development of a diabetic cardiomyopathy is a multifactorial process, and evidence is accumulating that defects in intracellular free calcium concentration [Ca2+]i or its homeostasis are related to impaired mechanical performance of the diabetic heart leading to a reduction in contractile dysfunction. Defects in ryanodine receptor, reduced activity of the sarcoplasmic reticulum calcium pump (SERCA) and, along with reduced activity of the sodium-calcium exchanger (NCX) and alterations in myofilament, collectively cause a calcium imbalance within the diabetic cardiomyocytes. This in turn is characterized by cytosolic calcium overloading or elevated diastolic calcium leading to heart failure. Numerous studies have been performed to identify the cellular, subcellular, and molecular derangements in diabetes-induced cardiomyopathy (DCM), but the precise mechanism(s) is still unknown. This review focuses on the mechanism behind DCM, the onset of contractile dysfunction, and the associated changes with special emphasis on hyperglycemia, mitochondrial dysfunction in the diabetic heart. Further, management strategies, including treatment and emerging therapeutic modalities, are discussed.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Singh RM,Waqar T,Howarth FC,Adeghate E,Bidasee K,Singh Jdoi
10.1007/s10741-017-9663-ysubject
Has Abstractpub_date
2018-01-01 00:00:00pages
37-54issue
1eissn
1382-4147issn
1573-7322pii
10.1007/s10741-017-9663-yjournal_volume
23pub_type
杂志文章,评审abstract::Heart failure (HF) is associated with a high morbidity and mortality in the Western World. Our knowledge of the epidemiology, pathophysiology, and therapy has improved dramatically during the last 20 years. Pharmacological treatment, as it stands today, is a combination of preventive and symptomatic strategies. The ma...
journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-006-9482-z
更新日期:2006-06-01 00:00:00
abstract::Diabetes mellitus is a chronic disease requiring lifelong control with hypoglycemic agents that must demonstrate excellent efficacy and safety profiles. In patients taking glucose-lowering drugs, hypoglycemia is a common cause of death associated with arrhythmias, increased thrombus formation, and specific effects of ...
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2012-11-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9646-z
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2014-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9037-y
更新日期:2007-12-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1007/s10741-017-9611-x
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2013-07-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2012-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s10741-007-9061-y
更新日期:2008-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/a:1011405926588
更新日期:2001-03-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1007/s10741-008-9090-1
更新日期:2008-12-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章
doi:10.1007/s10741-017-9656-x
更新日期:2018-01-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2001-12-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
doi:10.1023/A:1009813621103
更新日期:2000-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-03-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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更新日期:2009-09-01 00:00:00
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,评审
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journal_title:Heart failure reviews
pub_type: 杂志文章,meta分析,评审
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