Therapeutic effects of the combination of inhaled beta2-agonists and beta-blockers in COPD patients with cardiovascular disease.

Abstract:

:Chronic obstructive pulmonary disease (COPD) is a major health problem worldwide, with co-morbidities contributing to the overall severity and mortality of the disease. The incidence and prevalence of cardiovascular disease among COPD patients are high. Both disorders often co-exist, mainly due to smoking, but they also share common underlying risk factors, such as aging and low-grade systemic inflammation. The therapeutic approach is based on agents, whose pharmacological properties are completely opposed. Beta2-agonists remain the cornerstone of COPD treatment due to their limited cardiac adverse effects. On the other hand, beta-blockers are administered in COPD patients with cardiovascular disease, but despite their proven cardiac benefits, they remain underused. There is still a trend among physicians over underprescription of these drugs in patients with heart failure and COPD due to bronchoconstriction. Therefore, cardioselective beta-blockers are preferred, and recent meta-analyses have shown reduced rates in mortality and exacerbations in COPD patients treated with beta-blockers.

journal_name

Heart Fail Rev

journal_title

Heart failure reviews

authors

Petta V,Perlikos F,Loukides S,Bakakos P,Chalkias A,Iacovidou N,Xanthos T,Tsekoura D,Hillas G

doi

10.1007/s10741-017-9646-z

subject

Has Abstract

pub_date

2017-11-01 00:00:00

pages

753-763

issue

6

eissn

1382-4147

issn

1573-7322

pii

10.1007/s10741-017-9646-z

journal_volume

22

pub_type

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