Abstract：
:Despite remarkable progress in the therapeutic approach of patients with chronic heart failure (CHF), exercise intolerance remains one of the hallmarks of the disease. During the past two decades, evidence has accumulated to underscore the key role of both endothelial dysfunction and skeletal muscle wasting in the process that gradually leads to physical incapacity. Whereas reverse ventricular remodeling has been attributed to aerobic exercise training, the vast majority of studies conducted in this specific patient population emphasize the reversal of peripheral abnormalities. In this review, we provide a general overview on underlying pathophysiological mechanisms. In addition, emphasis is put on recently identified pathways, which contribute to a deeper understanding of the main causes of exercise tolerance and the potential for reversal through exercise training. Recently, deficient bone marrow-related endothelial repair mechanisms have received considerable attention. Both acute exercise bouts, as well as exercise training, affect the mobilization of endothelial progenitor cells and their function. The observed changes following exercise training are believed to significantly contribute to improvement of peripheral endothelial function, as well as exercise capacity. With regard to skeletal muscle dysfunction and energy deprivation, adiponectin has been suggested to play a significant role. The demonstration of local skeletal muscle adiponectin resistance may provide an interesting and new link between the insulin resistant state and skeletal muscle wasting in CHF patients.
journal_name
Heart Fail Revjournal_title
Heart failure reviewsauthors
Conraads VM,Van Craenenbroeck EM,De Maeyer C,Van Berendoncks AM,Beckers PJ,Vrints CJdoi
10.1007/s10741-012-9324-0subject
Has Abstractpub_date
2013-01-01 00:00:00pages
65-77issue
1eissn
1382-4147issn
1573-7322journal_volume
18pub_type
杂志文章,评审abstract：:Significant growth in the elderly population (age ≥ 65 years) with heart failure (HF) has taken place in developed countries and is occurring in most developing countries. Projections from population studies in the United States, Europe and other developed countries suggest that this trend will very likely continue an...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9299-x
更新日期：2012-09-01 00:00:00
abstract：:The prevalence of heart failure (HF) is increasing. A distinction is made between diastolic HF (preserved left ventricular ejection fraction (LVEF)) and systolic HF (reduced LVEF). Advanced glycation end-products (AGEs) are crystallized proteins that accumulate during ageing, but are particularly increased in patients...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9225-z
更新日期：2012-03-01 00:00:00
abstract：:Right ventricular (RV) diastolic dysfunction was first reported as an indicator for the assessment of ventricular dysfunction in heart failure a little over two decades ago. However, the underlying mechanisms and precise role of RV diastolic dysfunction in heart failure remain poorly described. Complexities in the str...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-015-9472-0
更新日期：2015-05-01 00:00:00
abstract：:Cardiac fibrosis is associated with non-ischemic dilated cardiomyopathy, increasing its morbidity and mortality. Cardiac fibroblast is the keystone of fibrogenesis, being activated by numerous cellular and humoral factors. Macrophages, CD4+ and CD8+ T cells, mast cells, and endothelial cells stimulate fibrogenesis dir...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09940-0
更新日期：2020-03-13 00:00:00
abstract：:Myocarditis (MCD) is a type of inflammatory disease in which inflammatory cells infiltrate the myocardium, leading to cardiac dysfunction, myocardial necrosis, and fibrosis. Although it has been reported that MCD is mediated by T cells, the immune system is complex and includes many types of immune cells that interact...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-019-09799-w
更新日期：2019-11-01 00:00:00
abstract：:Anemia is common in Congestive Heart Failure (CHF) and is associated with an increased mortality, morbidity and progressive renal failure. The most common causes of the anemia in CHF are (1) the associated Chronic Kidney Disease (CKD), which causes depression of erythropoietin (EPO) production in the kidney, and (2) e...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9194-2
更新日期：2011-11-01 00:00:00
abstract：:To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the f...
journal_title：Heart failure reviews
pub_type： 杂志文章
doi：10.1007/s10741-017-9656-x
更新日期：2018-01-01 00:00:00
abstract：:In this paper, two different aspects of the relationship between chronic kidney disease and sudden cardiac death (SCD) have been reviewed. In end-stage renal disease patients, SCD risk is increased, and among patients implanted with a cardioverter defibrillator (ICD), dialysed ones carry a superior relative risk compa...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9210-6
更新日期：2011-11-01 00:00:00
abstract：:Acute heat failure syndromes are a heterogenous group of conditions. Chronic heart failure exacerbations represent the vast majority of cases. Pathophysiologic mechanisms, such as hypotension with peripheral tissue hypoperfusion, renal function impairment and myocardial ischemia and injury, adversely affect patients' ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9014-5
更新日期：2007-06-01 00:00:00
abstract：:Cell transplantation is emerging as a new treatment designed tot improve the poor outcome of patients with cardiac failure. Its rationale is that implantation of contractile cells into postinfarction scars can functionally rejuvenate these areas. Primarily for practical reasons, autologous skeletal myoblasts have been...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1024705214292
更新日期：2003-07-01 00:00:00
abstract：:Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by neoplastic transformation of pluripotent cells due to a typical cytogenetic and molecular mutation known as Philadelphia (Ph) chromosome. In 2001, the introduction of the tyrosine kinasis inhibitor (TKI) imatinib as a therapeutic strategy...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09926-y
更新日期：2020-05-01 00:00:00
abstract：:Heart failure is a complex clinical syndrome associated with a significant morbidity and mortality burden. Reductions in left ventricular (LV) function trigger adaptive mechanisms, leading to structural changes within the LV and the potential development of dyssynchronous ventricular activation. This is the substrate ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-018-9734-8
更新日期：2019-01-01 00:00:00
abstract：:The pathophysiology of heart failure (HF) is characterized by an abnormal activation of neurohumoral systems, including the sympathetic nervous and the renin-angiotensin-aldosterone systems, which have long-term deleterious effects on the disease progression. Perpetuation of this neurohumoral activation is partially d...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-014-9427-x
更新日期：2014-11-01 00:00:00
abstract：:Brief ischemia to the myocardium initiates a cascade of biochemical events in cardiac myocytes that protects the heart muscle during subsequent ischemic insults. This phenomenon is called ischemic preconditioning. If an acute myocardial infarction is preceded by preinfarction angina, it results in smaller infarction s...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-007-9037-y
更新日期：2007-12-01 00:00:00
abstract：:In response to a prolonged pressure- or volume-overload, alterations occur in myocardial fatty acid, glucose, and glycogen metabolism. Oxidation of long chain fatty acids has been found to be reduced in hypertrophied hearts compared to non-hypertrophied hearts. However, this observation depends upon the degree of card...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1015380609464
更新日期：2002-04-01 00:00:00
abstract：:Magnetic resonance spectroscopy (MRS) is the only non-invasive, non-radiation-based technique for investigating the metabolism of living tissue. MRS of protons (1H-MRS), which provides the highest sensitivity of all MR-visible nuclei, is a method capable of detecting and quantifying specific cardiac biomolecules, such...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-012-9341-z
更新日期：2013-09-01 00:00:00
abstract：:Recent cardiovascular outcome trials have highlighted the propensity of the antidiabetic agents, SGLT2 inhibitors (SGLT2is or -flozin drugs), to exert positive clinical outcomes in patients with cardiovascular disease at risk for major adverse cardiovascular events (MACEs). Of interest in cardiac diabetology is the ph...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09996-y
更新日期：2020-06-24 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) is due to severe acute respiratory syndrome coronavirus (SARS-CoV)-2 which binds and enters the host cells through the angiotensin-converting enzyme (ACE)2. While the potential for benefit with the use of renin-angiotensin-aldosterone system inhibitors (RAASi) and the risks from sto...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-10022-4
更新日期：2020-09-01 00:00:00
abstract：:Although mineralocorticoid antagonists (MRAs) have been proposed as effective fourth-line blood pressure (BP) lowering agents in resistant hypertension, this effect in heart failure is undetermined. In this synthesis of heart failure randomized controlled trials (RCTs), we evaluated the extent of BP lowering following...
journal_title：Heart failure reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10741-018-9689-9
更新日期：2018-07-01 00:00:00
abstract：:Ultrafiltration (UF) has emerged as an alternative therapy for acute decompensated heart failure (ADHF) due to its physiological benefits such as improvement in neurohormonal activation. We performed a systematic review and a meta-analysis to evaluate the efficacy, safety, and the impact on outcomes for UF therapy as ...
journal_title：Heart failure reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1007/s10741-016-9559-2
更新日期：2016-09-01 00:00:00
abstract：:Cardiotoxicity is a well-known side effect of doxorubicin (DOX), but the mechanisms leading to this phenomenon are still not completely clear. Prediction of drug-induced dysfunction onset is difficult and is still largely based on detection of cardiac troponin (cTn), a circulating marker of heart damage. In the last y...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9653-0
更新日期：2018-01-01 00:00:00
abstract：:Congestive heart failure is most often caused by scar from coronary occlusion. The transition from occluded vessel to scar to dilation results in a remodeled ventricle that changes shape from ellipse to sphere. This shape change following an index event is called remodeling and a surgical approach for restoration (bri...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-005-6801-8
更新日期：2004-10-01 00:00:00
abstract：:Heart failure with preserved ejection fraction (HFpEF) accounts for almost one-half of all heart failure (HF) patients and continues to increase in prevalence. While mortality with heart failure with reduced ejection fraction (HFrEF) has decreased over the past few decades with use of evidence-based HFrEF therapy, mor...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09958-4
更新日期：2020-05-13 00:00:00
abstract：:Diabetes mellitus is a chronic disease requiring lifelong control with hypoglycemic agents that must demonstrate excellent efficacy and safety profiles. In patients taking glucose-lowering drugs, hypoglycemia is a common cause of death associated with arrhythmias, increased thrombus formation, and specific effects of ...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-017-9647-y
更新日期：2018-05-01 00:00:00
abstract：:Diabetes mellitus is one of the leading causes of death, and the majority of these deaths are associated with cardiovascular diseases. Development and progression of myocardial infarction leading to heart failure is much more complex and multifactorial in diabetics compared with non-diabetics. Despite significant adva...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9172-8
更新日期：2010-11-01 00:00:00
abstract：:Since its discovery in 1988, there has been increasing evidence that endothelin-1 (ET-1) plays an important role in the pathophysiology of hypertension and its related end-organ damages. First studies, using ET-1 administration in animals or in humans suspected this role by demonstrating the hypertensive properties of...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1011419223152
更新日期：2001-12-01 00:00:00
abstract：:Cardiac resynchronization therapy (CRT) has revolutionized the treatment of selected patients with systolic heart failure. It is well recognized, however, that the symptomatic response to and the outcome of CRT is highly variable. The degree of pre-implant mechanical dyssynchrony and the extent as well as the localiza...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-010-9213-3
更新日期：2011-05-01 00:00:00
abstract：:In the past decade, cardiac pacing devices (either permanent pacemakers or Implanted Cardioverter Defibrillators) have become increasingly common in patients with heart failure. The manner in which the device is programmed to pace the heart can have significant implications on cardiac hemodynamics, both positive and n...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-011-9239-1
更新日期：2011-09-01 00:00:00
abstract：:Dilated cardiomyopathy (DCM) represents one of the primary cardiomyopathies and may lead to heart failure and sudden death. Until recently, ventricular arrhythmias were considered to be a direct consequence of the systolic dysfunction of the left ventricle (LV) and guidelines for implantable cardioverter defibrillator...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1007/s10741-020-09933-z
更新日期：2020-02-13 00:00:00
abstract：:The prognosis for patients with congestive heart failure (CHF) has been improved as a result of the use of angiotensin converting enzyme inhibitors and beta-adrenergic receptor blockers. The success of these therapies underscores the pathogenic role of neurohormonal activation in CHF. Clinical and experimental evidenc...
journal_title：Heart failure reviews
pub_type： 杂志文章,评审
doi：10.1023/a:1011405926588
更新日期：2001-03-01 00:00:00
